Chetoni e Derivati
I chetoni sono composti organici che contengono un gruppo carbonilico (C=O) legato a due atomi di carbonio, formando una struttura in cui il gruppo carbonilico è affiancato da gruppi alchilici o arilici. In farmacologia, i chetoni sono utilizzati nella formulazione di API grazie alla loro capacità di migliorare la solubilità e la stabilità dei principi attivi. Alcuni chetoni possiedono proprietà antinfiammatorie, analgesiche e antimicrobiche. I derivati dei chetoni includono composti in cui il gruppo carbonilico è modificato, come gli enoli, che trovano applicazione nella sintesi di farmaci e come intermedi chimici nella produzione di altri composti bioattivi. I derivati dei chetoni sono impiegati nella progettazione di nuovi farmaci, inclusi quelli per il trattamento di malattie neurodegenerative, disturbi metabolici e alcuni tipi di cancro, grazie ai loro effetti specifici sugli enzimi e sui processi cellulari.
Trovati 2393 prodotti di "Chetoni e Derivati"
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5′-Acetyl-2′-fluoro-3-methyl-[1,1′-biphenyl]-4-carbaldehyde
CAS:Purezza:≥95%Peso molecolare:256.2760014′-Chloro-3′-(trifluoromethoxy)acetophenone
CAS:Formula:C9H6ClF3O2Colore e forma:SolidPeso molecolare:238.593′,4′-Difluoropropiophenone
CAS:Formula:C9H8F2OPurezza:97%Colore e forma:LiquidPeso molecolare:170.1591,1′-(2-Hydroxy-5-methyl-1,3-phenylene)diethanone
CAS:Formula:C11H12O3Purezza:95.0%Peso molecolare:192.214Nabumetone Dimer Impurity
CAS:Prodotto controllato<p>Impurity Nabumetone Dimer Impurity<br>Applications An impurity in a Nabumetone (N200500) drug substance.<br>References Friedel, H., et al.: Drugs, 35, 504 (1988), Davies, N., et al.: Clin. Pharmacokinet., 33, 403 (1997),<br></p>Formula:C27H26O3Colore e forma:NeatPeso molecolare:398.49rac-2’,4’-Dimethyl Ketoprofen
CAS:Prodotto controllato<p>Applications rac-2’,4’-Dimethyl Ketoprofen is an impurity of Ketoprofen (K200800), an anti-inflammatory and analgesic agent.<br>References Ueno, K., et al.: J. Med. Chem., 19, 941 (1976); Liversidge, G.G., Anal. Profiles Drug Subs., 10, 443 (1981); Jamali, F., et al.: Clin. Pharmacokinet., 19, 197 (1990)<br></p>Formula:C18H18O3Colore e forma:NeatPeso molecolare:282.334'-Isobutyl-2,2-dibromopropiophenone
CAS:Prodotto controllato<p>Applications Intermediate in the synthesis of Ibuprofen.<br></p>Formula:C13H16Br2OColore e forma:NeatPeso molecolare:348.073-Methoxy Acetaminophen-d3
CAS:Prodotto controllato<p>Applications 3-Methoxy Acetaminophen-d3 is deuterium labeled 3-Methoxy Acetaminophen (M226050). 3-Methoxy Acetaminophen is a metabolite of Acetaminophen (A161220), an analgesic and antipyretic agent used as a pain reliever to treat headache, muscle aches, and arthritis (1,2,3).<br>References (1) McGill, M. R. and Jaeschke, H. Pharm Res. 30, 2174 (2013)(2) Fairbrother, J.E., et al.: Anal. Profiles Drug Subs., 3, 1 (1974) (3) Hinson, J.A., et al.: Rev. Biochem. Toxicol., 2, 103 (1980)<br></p>Formula:C92H3H8NO3Colore e forma:NeatPeso molecolare:184.2073-(6-Methoxy-2-naphthalenyl)-5-methylcyclohexanone (Impurity)
CAS:Formula:C18H20O2Colore e forma:NeatPeso molecolare:268.35R-(-)-Norapomorphine Hydrochloride
CAS:Prodotto controllato<p>Applications An Apomorphine derivative as inhibitor of amyloid-β (Aβ) fibril formation and their use in amyloidosis based disease.<br>References Howlett, D., et al.: Biochem. J., 340, 283 (1999), Kuner, P., et al.: J. Biol. Chem., 275, 1673 (2000), Ono, K., et al.: J. Neurosci. Res., 75, 742 (2004),<br></p>Formula:C16H15NO2•HClPurezza:>90%Colore e forma:NeatPeso molecolare:253.3036466,6'-Dimethoxy-2,2'-binaphthalene
CAS:Prodotto controllato<p>Applications 6,6'-Dimethoxy-2,2'-binaphthalene, can be used for the synthesis of novel classes of non-steroidal substrate mimetics, as inhibitors of human CYP17. It is also an impurity of Nabumetone (N200500), a non-steroidal anti-inflammatory drug, acting as anti-inflammatory agent.<br>References Kumpulainen, H., et al.: J. Med. Chem., 49, 1207 (2006); Pinto-Bazurco, M. A. E., et al.: Bioorg. Med. Chem. Lett., 18, 267 (2008);<br></p>Formula:C22H18O2Colore e forma:NeatPeso molecolare:314.38D 13223-d4 (Flupirtine Metabolite)
CAS:Prodotto controllato<p>Applications The major active labelled metabolite of Flupirtine in human plasma. A potassium channel opener<br>References Niebch, G., et al.: Arzneim.-Forsch., 42, 1343 (1992), Friedel, H., et al.: Drugs, 45, 548 (1993), Fu, I., et al.: J. Pharm. Biomed. Anal., 18, 347 (1998),<br></p>Formula:C14H12D4ClFN4OColore e forma:NeatPeso molecolare:314.78Ketoprofen-13CD3 Methyl Ester
CAS:Prodotto controllato<p>Applications An intermediate for the synthesis of Labelled Ketoprofen.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Derewenda, Z., et al.: J. Mol. Biol., 227, 818 (1992), Grochulski, P., et al.: J. Biol. Chem., 268, 12843 (1993).<br></p>Formula:C1613CH13D3O3Colore e forma:NeatPeso molecolare:272.32(±)-Ibuprofen-d3, Sodium Salt (α-methyl-d3)
CAS:Prodotto controllato<p>Applications (±)-Ibuprofen-d3, Sodium Salt (alpha-methyl-d3) (CAS# 1219805-09-0) is a useful isotopically labeled research compound.<br></p>Formula:C13H14D3NaO2Colore e forma:NeatPeso molecolare:231.292-Hydroxy Nabumetone
CAS:Prodotto controllatoFormula:C15H18O2Colore e forma:White To Off-WhitePeso molecolare:230.30N-Desethyl 3-Bromo Lidocaine
CAS:Prodotto controllato<p>Applications Intermediate in the preparation of hydroxylated Lidocaine metabolites.<br></p>Formula:C12H17BrN2OColore e forma:NeatPeso molecolare:285.185-(6-Methoxy-2-naphthalenyl)-3-methyl-2-cyclohexen-1-one
CAS:Prodotto controllatoFormula:C18H18O2Colore e forma:NeatPeso molecolare:266.33(S)-(+)-Ibuprofen Propylene Glycol Ester
CAS:Prodotto controllatoFormula:C16H24O3Colore e forma:NeatPeso molecolare:264.36Methyl 5-Methoxy-2-methylindole-3-acetate
CAS:Prodotto controllato<p>Applications Intermediate in the preparation of Indomethacin<br>References Kalgutkar, A.S., et al.: Bioorg. Med. Chem., 13, 6810 (2005),<br></p>Formula:C13H15NO3Colore e forma:NeatPeso molecolare:233.26(±)-Carisoprodol-d7 (iso-propyl-d7)
CAS:Prodotto controllato<p>Applications (±)-Carisoprodol-d7 (iso-propyl-d7) (CAS# 1218911-01-3) is a useful isotopically labeled research compound. As a deuterated drug analog, this compound can be used for inter-patient variability.<br>References Gant, T., et.al., U.S. Pat. Appl. Publ., 28,(2010);<br></p>Formula:C12H17D7N2O4Colore e forma:NeatPeso molecolare:267.383,4-Methylenedioxy Propiophenone
CAS:Prodotto controllato<p>Applications Intermediate in the production of Isosafrole and Ethylone.<br>References Katoch-Rouse, R., et al.: J. Med. Chem., 46, 642 (2003), Andrade, E., et al.: Chem. Biodivers., 5, 197 (2008),<br></p>Formula:C10H10O3Colore e forma:NeatPeso molecolare:178.181-(3,4-Dimethylphenyl)ethanol
CAS:Prodotto controllato<p>Applications 1-(3,4-Dimethylphenyl)ethanol is an intermediate in the production of Medetomidine (M203250), α2-Adrenergic agonist. Sedative; analgesic.<br>References Kagechika, H., et al.: J. Med. Chem., 32, 1098 (1989), ; Scheinin, M., et al.: Br. J. Clin. Pharmacol., 24, 443 (1987),<br></p>Formula:C10H14OColore e forma:NeatPeso molecolare:150.22(S)-(+)-Ibuprofen 2-(Benzyloxy)propan-1-yl Ester
Prodotto controllato<p>Applications (S)-(+)-Ibuprofen 2-(Benzyloxy)propan-1-yl Ester is an intermediate in the synthesis of (S)-(+)-Ibuprofen Propylene Glycol Ester (I140100), a derivative of (S)-(+)-Ibuprofen (I140010), a nonsteroidal anti-inflammatory drug (NSAID).<br>References Busson, M., et al.: J. Int. Med Res., 14, 53 (1986), Meade, E.A., et al.: J. Biol. Chem., 268, 6610 (1993), Davies, N.M., et al.: Clin. Pharmacokinet., 34, 101 (1998),<br></p>Formula:C23H30O3Colore e forma:NeatPeso molecolare:354.483(+)-N,O-Didesmethyl Tramadol
CAS:Prodotto controllato<p>Applications An optically active metabolite of Tramadol.<br>References Garrido, M., et al.: J. Pharmacol. Exp. Ther., 305, 710 (2003), Pedersen, R., et al.: Eur. J. Clin. Pharmacol., 62, 513 (2006),<br></p>Formula:C14H21NO2Colore e forma:NeatPeso molecolare:235.324-Morpholineethanol-d4
CAS:Prodotto controllato<p>Applications Labelled analogue 4-(2-Hydroxyethyl)morpholine, a morphiline derivative used in the preparation of ester prodrugs of naproxen. 4-(2-Hydroxyethyl)morpholine was also shown to induce repair in rat hepatocyte primary culture/DNA.<br></p>Formula:C6H9D4NO2Colore e forma:NeatPeso molecolare:135.20(-)-N-Desmethyl Tramadol
CAS:Prodotto controllato<p>Applications An optically active metabolite of Tramadol.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Lintz, V.W., et al.: Arzneim.-Forsch./Drug Res., 31, II, 11, 1932 (1981)<br></p>Formula:C15H23NO2Colore e forma:NeatPeso molecolare:249.353-(Cyanomethyl)benzoic Acid
CAS:Prodotto controllato<p>Impurity Ketoprofen EP Impurity H<br>Applications 3-(Cyanomethyl)benzoic Acid (Ketoprofen EP Impurity H) is a reagent used in the synthesis of various pharmaceutically important compounds, such as its use in the synthesis of neprilysin inhibitors.<br>References Solomon, S.D., et al.: Lancet., 380 1387 (2012); Dadd, M.R., et al.: Enzyme. Microb. Tehcnol., 29, 20 (2001);<br></p>Formula:C9H7NO2Colore e forma:NeatPeso molecolare:161.1616,17-Dehydro Capsaicin
CAS:Prodotto controllato<p>Stability Light Sensitive<br>Applications A dehydrogenated metabolite of Capsaicin (C175680).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Glinsukon, T., et al.: Toxicon, 18, 215 (1980), Obach, R., et al.: Drug Metab. Dispos., 29, 1599 (2001), Reilly, C., et al.: Toxicol. Sci., 73, 170 (2003),<br></p>Formula:C18H25NO3Colore e forma:Off-White To BrownPeso molecolare:303.41-(2,5-Dimethylphenyl)ethanol
CAS:Prodotto controllato<p>Applications 1-(2,5-Dimethylphenyl)ethanol can be used as a reagent in reactions or as a aroma compound<br>References Zhou, J., et al.: Yuanyi Xuebao., 37, 1621-1628 (2010)<br></p>Formula:C10H14OColore e forma:NeatPeso molecolare:150.22Trimebutine EP Impurity E-Nitroso
Prodotto controllatoFormula:C21H26N2O6Colore e forma:NeatPeso molecolare:402.441Trimebutine-d9 Maleate Salt
CAS:Prodotto controllato<p>Applications Trimebutine-d9 Maleate Salt, is the labeled analogue of Trimebutine Maleate Salt (T795605), acting as an opioid receptor agonist. Antispasmodic.<br>References Delvaux, M., et al.: J. Int. Med. Res., 25, 225 (1997), Lavit, M., et al.: Arzneim.-Forsch., 50, 640 (2000),<br></p>Formula:C22H20D9NO5·C4H4O4Colore e forma:NeatPeso molecolare:512.6Nabumetone-d3
CAS:Prodotto controllato<p>Applications Labelled Nabumetone. Anti-inflammatory. Antibacterial.<br>References Kumpulainen, H., et al.: J. Med. Chem., 49, 1207 (2006),<br></p>Formula:C152H3H13O2Colore e forma:NeatPeso molecolare:231.30L-Propoxyphene-d5 HCl (propionyl-d5)
CAS:Prodotto controllato<p>Applications L-Propoxyphene-d5 Hydrochloride is the isotope labelled analog and L-isomer of Propoxyphene Hydrochloride (P831500); a controlled substance (opiate) and analgesic (narcotic). The α-DL-and D-diastereoisomers possess marked analgesic activity in contrast to the β-diastereoisomers which are substantially inactive. Oral administration of L-Propoxyphene Hydrochloride enhances the analgesic activity of D-Propoxyphene Hydrochloride.<br>References Goldenthal, E.I., et al.: Toxicol. Appl. Pharmacol., 18, 185 (1971); McEwan, B., et al.: Anal. Profiles Drug Subs., 1, 301 (1972); Murphy, P.J., et al.: J. Pharmacol. Exp. Ther., 199, 415 (1976)<br></p>Formula:C22H25D5ClNO2Colore e forma:NeatPeso molecolare:380.962,2-Dimethoxy-2-phenylacetophenone
CAS:<p>Applications 2,2-Dimethoxy-2-phenylacetophenone (cas# 24650-42-8) is a compound useful in organic synthesis.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>Formula:C16H16O3Colore e forma:White PowderPeso molecolare:256.30N-(1,5-Dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)-N-methylnitrous amide
CAS:Prodotto controllatoFormula:C12H14N4O2Colore e forma:NeatPeso molecolare:246.276-Benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid, racemic
CAS:<p>6-Benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid, racemic is a drug product that is used as an analytical standard in the development of new drugs. It is also used to study the metabolism of drugs. 6BPDC has been shown to inhibit bacterial growth by binding to DNA and RNA, thereby preventing transcription and replication. This metabolite can be synthesized in the laboratory.</p>Formula:C15H13NO3Purezza:Min. 95%Peso molecolare:255.27 g/molN-(4-Hydroxyphenyl)propanamide
CAS:<p>The N-(4-hydroxyphenyl)propionamide (HPPA) is a synthetic drug that binds to the human liver. It has been shown to be effective in preventing implantation of fertilized eggs, and can be used as a diagnostic agent for determining the presence of HPPA in human liver tissue. HPPA is also used as a diluent for other drugs. The HPPA binds to chromatographic components and can be detected using electrochemical detection, which allows it to be used as a targetable probe for cancer research. HPPA is also used to study iontophoretic transport of ions across reconstituted membranes in vitro.</p>Formula:C9H11NO2Purezza:(%) Min. 97%Peso molecolare:165.19 g/molPelubiprofen
CAS:<p>Pelubiprofen is a non-steroidal anti-inflammatory agent and a COX-2 inhibitor, which effectively reduces PGE(2) production by inhibiting COX activity.</p>Formula:C16H18O3Purezza:99.69%Colore e forma:SolidPeso molecolare:258.31
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