Derivati delle Purine e Pirimidine
Le purine hanno una struttura biciclica, composta da un anello a sei membri fuso con un anello a cinque membri, entrambi contenenti atomi di azoto in posizioni chiave. I derivati delle purine, come l’adenina e la guanina, sono essenziali per la formazione del DNA e dell’RNA. Questi composti trovano applicazione terapeutica nei trattamenti contro il cancro e le malattie virali, inibendo la replicazione cellulare. Le pirimidine, invece, hanno una struttura monociclica a sei membri con due atomi di azoto. I loro derivati, come la citosina, la timina e l’uracile, sono anch’essi componenti fondamentali del DNA e dell’RNA e vengono utilizzati in chemioterapia e nei trattamenti antivirali.
Presso CymitQuimica, offriamo derivati delle purine e pirimidine per la ricerca in biologia molecolare, genomica e sviluppo di terapie innovative.
Trovati 8897 prodotti di "Derivati delle Purine e Pirimidine"
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4-(2-fluorophenyl)-6-(thiophen-2-yl)pyrimidin-2-amine
CAS:Purezza:95.0%Peso molecolare:271.30999755859375Sumatriptan Succinate
CAS:Prodotto controllato<p>Applications Sumatriptan Succinate is a selective 5-HT1B/1D-receptor agonist with anticonvulsant properties (1,2). Sumatriptan Succinate is used for migraine relief (2).<br>References (1) Razzaque, Z., et al.: Br J Clin Pharmacol. 47, 75 (1999) (2) Cady, R. K., et al.: J Headache Pain. 18, 17 (2017)<br></p>Formula:C14H21N3O2S·C4H6O4Colore e forma:White To Off-WhitePeso molecolare:413.492-Hydrazino Adenosine
CAS:Prodotto controllato<p>Stability Moisture Sensitive<br>Applications A useful synthetic intermediate for making potent and selective coronary vasodilators.<br>References Niiya, K., et al.: J. Med. Chem., 35, 4557 (1992)<br></p>Formula:C10H15N7O4Colore e forma:NeatPeso molecolare:297.274-Chloro-5,6-dimethyl-2-(trifluoromethyl)-pyrimidine
CAS:Formula:C7H6ClF3N2Purezza:97.0%Colore e forma:LiquidPeso molecolare:210.583-Amino-4-carbamoylpyrazole Hemisulfate
CAS:Prodotto controllato<p>Impurity Allopurinol EP Impurity A / Allopurinol USP Related Compound A<br>Stability Hygroscopic<br>Applications 3-Amino-4-carbamoylpyrazole Hemisulfate (Allopurinol EP Impurity A) is an impurity of Allopurinol (A547300), a pyrazole derivative that has been shown to induce neoplasm immunogenicity.<br>References Nicolin, A. et al.: Cancer, Chemother. Rep., 57, 3 (1973); Bonmassar, E. et al.: Cancer Res., 35, 1957 (1975);<br></p>Formula:C4H6N4O·H2O4SColore e forma:White To Light BrownPeso molecolare:350.313,5-Dimethyl-1-adamantanol
CAS:Prodotto controllato<p>Impurity Memantine USP Related Compound B (3,5-Dimethyladamantane-1-ol)<br>Applications 3,5-Dimethyl-1-adamantanol is an impurity of Memantine (M218000). Memantine impurity B. Memantine USP Related Compound B (3,5-Dimethyladamantane-1-ol).<br>References England, P., et al.: Biochemistry, 43, 11623 (2004), Schousboe, A., et al.: Eur. J. Pharmacol., 500, 281 (2004), Horvat, S., et al.: J. Med. Chem., 49, 3136 (2006),<br></p>Formula:C12H20OColore e forma:WhitePeso molecolare:180.292-(3-Cyano-4-hydroxyphenyl)-4-methyl-1,3-thiazole-5-carboxylic Acid Ethyl Ester
CAS:<p>Applications 2-(3-Cyano-4-hydroxyphenyl)-4-methyl-1,3-thiazole-5-carboxylic Acid Ethyl Ester, can be used for the synthesis of Febuxostat (F229000), an antipodagrics.<br>References Zheng, F., et al.: Zhongguo Yiyao Gongye Zazhi, 40, 726 (2009);<br></p>Formula:C14H12N2O3SColore e forma:NeatPeso molecolare:288.32N-(1-phenylethyl)guanidine hydrochloride
CAS:Formula:C9H14ClN3Purezza:95.0%Colore e forma:SolidPeso molecolare:199.68N-((4,6-dimethoxypyrimidin-2-yl)carbamoyl)-3-(trifluoromethyl)pyridine-2-sulfonamide
CAS:Purezza:98%Colore e forma:SolidPeso molecolare:407.32000732-(4-Chlorophenyl)amino-4-phenylpyrimidine
CAS:Purezza:95.0%Colore e forma:Solid, No data available.Peso molecolare:281.739990234375N,N'-Di-Boc-guanidine
CAS:Purezza:99.0%Colore e forma:Solid, Crystalline Powder or PowderPeso molecolare:259.30599975585943-Nitro-L-tyrosine-d3
CAS:Prodotto controllato<p>Applications A labelled marker for peroxynitrite. Oxidant and cytotoxic agent.<br>References Sekiguchi, M., et al.: Brain Res., 978, 228 (2003), van den Tweel, E., et al.: J. Neurobiol., 167, 64 (2005), Shirakura, T., et al.: Biol. Pharm. Bull., 28, 1658 (2005),<br></p>Formula:C9D3H7N2O5Colore e forma:NeatPeso molecolare:229.2Thyroxine Ethyl Ester
CAS:Prodotto controllato<p>Applications An analog of Thyroxine (L425600) with stimulatory effects on human red blood cell membrane Ca2+-activated ATPase. It is a potential inactivator of iodothyronine deiodinase type II.<br>References Davis, F.B. et al.: J. Biol. Chem., 258, 12373 (1983); Safran, M. et al.: J. Biol. Chem., 268, 14224 (1993);<br></p>Formula:C17H15I4NO4Colore e forma:NeatPeso molecolare:804.924-Chloro Kynurenine-13C2,15N
CAS:Prodotto controllato<p>Applications 7-Cl-kynurenic acid (7-Cl-KYNA) is a potent, selective antagonist of the NMDA/glycine receptor but penetrates poorly through the blood-brain barrier. Its prodrug, L-4-Cl-kynurenine (4-Cl-KYN), readily enters the brain from the circulation and provides antiexcitotoxic neuroprotection after systemic application.<br>References Leeson, P., et al.: J. Med. Chem., 37, 4053 (1994), Hilmas, C., et al.: J. Neurosci., 2001, 21, 7463 (2001), Palmer, G., et al.: Curr. Drug Targets, 2, 241 (2001), Wu, H., et al.: Exp. Neurol., 177, 222 (2002),<br></p>Formula:C813C2H11ClN15NO3Colore e forma:NeatPeso molecolare:245.642-[5-amino-3-(2-furyl)-1H-pyrazol-1-yl]-6-isopropylpyrimidin-4(3H)-one
CAS:Purezza:95.0%Peso molecolare:285.3070068359375N-Hydroxymethyl Sumatriptan
CAS:Prodotto controllato<p>Applications Hydroxymethyl Sumatriptan is an analog of Sumatriptan (S810000), a serotonin 5HT1-receptor agonist.<br>References Humphrey, P.P.A., et al.: Brit. J. Pharmacol., 94, 1123 (1988), Doenicke, A., et al.: Lancet 1, 1309 (1988),<br></p>Formula:C15H23N3O3SColore e forma:NeatPeso molecolare:325.43Methotrexate dimethylamide
CAS:<p>Methotrexate dimethylamide is a research and development impurity standard with high purity. It is a synthetic drug product that can be custom synthesized to meet the needs of the customer. Methotrexate dimethylamide has been used as an analytical standard for HPLC analysis and as a natural metabolite in metabolism studies. This compound is also known as 71074-44-7, CAS No. 71074-44-7, or Metabolite.</p>Formula:C22H27N9O4Purezza:Min. 95%Peso molecolare:481.51 g/molTenofovir isoproxil monoester
CAS:<p>Tenofovir isoproxil monoester is a prodrug of Tenofovir, which is an antiviral drug. Tenofovir prevents the growth of HIV by interfering with the synthesis of viral DNA. The process development stage involves converting Tenofovir to its disoproxil monoester form, which has been shown to have greater antiviral activity than Tenofovir alone. This conversion process involves condensing one molecule of fumarate with two molecules of tenofovir, forming tenofovir disoproxil fumarate (TFD). TFD can be converted back to Tenofovir using hydrolysis and hydrogenation. Impurities in TFD include isopropyl tenofovir and unidentified impurities that are not present in the parent drug, tenofovir. Tenofovir Disoproxil Fumarate was also shown to be more potent than TFD and is undergoing clinical trials for</p>Formula:C14H22N5O7PPurezza:Min. 97 Area-%Colore e forma:White/Off-White SolidPeso molecolare:403.33 g/mol4-[[(2,4-Diamino-6-pteridinyl)methyl]methylamino]benzoic acid
CAS:<p>4-[[(2,4-Diamino-6-pteridinyl)methyl]methylamino]benzoic acid is a drug with low bioavailability. It is used to treat leishmaniasis, an infection caused by the parasite Leishmania. 4-[[(2,4-Diamino-6-pteridinyl)methyl]methylamino]benzoic acid inhibits the synthesis of folic acid by blocking the enzyme dihydrofolate reductase in the bacteria. This drug also has been shown to be effective against autoimmune diseases and inflammatory bowel disease. The terminal half-life of 4-[(2,4-diamino6 pteridinyl)methyl]methylamino benzoic acid is approximately 5 hours and it can be detected in urine for up to 12 hours after administration.</p>Formula:C15H15N7O2Purezza:(1H-Nmr) Min. 95 Area-%Colore e forma:Brown Yellow PowderPeso molecolare:325.33 g/molMemantine impurity IV
CAS:<p>Memantine impurity IV is a hydrolysis product of memantine. It appears as a white to off-white powder and has a molecular weight of 198.1 g/mol. Memantine impurity IV is an intermediate in the production of memantine and is therefore not used for any other purpose. The compound contains hydroxy groups, hydroxy, alcohols, and bridgehead groups which are efficient at hydrolyzing to form amino acids.</p>Formula:C12H21NO·HClPurezza:Min. 95%Colore e forma:White PowderPeso molecolare:231.76 g/molAllopurinol impurity C
CAS:<p>Allopurinol impurity C is a product of the reaction between allopurinol and n-butyl alcohol, which occurs in the presence of sodium hydroxide solution and dimethylformamide. The reaction condition is heated to reflux for 12 hours, after which the mixture is filtered and concentrated under reduced pressure. The resultant crude product is purified by column chromatography with ethyl acetate and then recrystallized from methanol. The synthesis scheme can be found in Figure 1.</p>Formula:C6H6N6OPurezza:Min. 95%Colore e forma:Slightly Yellow PowderPeso molecolare:178.15 g/molTenofovir disoproxil related compound B
CAS:<p>Tenofovir disoproxil related compound B is a peptidyl prodrug that is metabolized by esterases to tenofovir. It has been shown to be an effective agent against Mycobacterium tuberculosis and other bacterial species. Tenofovir disoproxil related compound B was also found to inhibit protein synthesis in Mycobacterium avium and Mycobacterium smegmatis, but not in Escherichia coli. This drug binds to the ribosome's 30S subunit, which blocks the binding of aminoacyl-tRNA and prevents the formation of peptide bonds. The mechanism of action for this drug is similar to that of the antibiotic erythromycin.</p>Formula:C8H9N5Purezza:Min. 98 Area-%Peso molecolare:175.19 g/molN-(5-Aminopentyl) methotrexate amide
CAS:<p>N-(5-Aminopentyl) methotrexate amide is a fluorescent probe that is used to study the transport of drugs across cell membranes. It binds to the plasma membrane of cells and can be visualized with a fluorescence microscope. N-(5-Aminopentyl) methotrexate amide has been shown to bind to leukemia cells in murine leukemia models. It has a high affinity for drug-resistant cells, which makes it useful for studying drug resistance mechanisms. This probe can be used at nanomolar concentrations for imaging studies, as well as for measuring the uptake of drugs into cancer cells by flow cytometry.</p>Formula:C25H34N10O4Purezza:Min. 95%Colore e forma:Yellow PowderPeso molecolare:538.6 g/mol4-[2'-(7''-Deazaguanine)ethyl]benzoic acid N-hydroxysuccinimide ester
CAS:<p>4-[2'-(7''-Deazaguanine)ethyl]benzoic acid N-hydroxysuccinimide ester is a useful intermediate in the synthesis of 7''-deazaguanine, which is a key building block in the synthesis of DNA. 4-[2'-(7''-Deazaguanine)ethyl]benzoic acid N-hydroxysuccinimide ester is a versatile building block that can be used in the synthesis of complex compounds. It has been shown to react with amines, sulfonyl chlorides, and epoxides to form amides, sulfonamides, and epoxy amines respectively. The CAS number for this compound is 204257-65-8.</p>Formula:C19H17N5O5Purezza:Min. 95%Peso molecolare:395.37 g/molEthyl 3-aminopyrazole-4-carboxylate
CAS:<p>Ethyl 3-aminopyrazole-4-carboxylate is an anticancer drug that inhibits the growth of cancer cells by inhibiting protein synthesis. It has been shown to inhibit the activity of dpp-iv and pde5, which are enzymes involved in cellular proliferation. Ethyl 3-aminopyrazole-4-carboxylate has also been shown to have antiinflammatory properties, which may be due to inhibition of prostaglandin synthesis. <br>Ethyl 3-aminopyrazole-4-carboxylate is a multinuclear compound that reacts with nitrogen atoms from the pyrazoles to form a stable molecule. Dimethylformamide is used as a solvent for this reaction. The synthesis of ethyl 3-aminopyrazole-4-carboxylate starts with acetylation, which converts the carboxylic acid group into an acetic acid group. The acetic acid group reacts with ammonia and hydrogen cyan</p>Formula:C6H9N3O2Purezza:Min. 95%Colore e forma:PowderPeso molecolare:155.16 g/molN-Acetylmemantine
CAS:<p>N-Acetylmemantine is a drug that inhibits the activity of acetylcholinesterase in the brain. It has been shown to inhibit cancer cell growth and induce apoptosis, as well as inhibit the reaction of hydrolysis of acetonitrile with hydrochloric acid in an organic solvent. N-Acetylmemantine is synthesized by heating ethylene in the presence of hydrochloric acid. The synthesis yields a white solid that consists mainly of N-acetylmethamphetamine. This drug interacts with cellular membranes, which may be due to its ability to react with cholesterol or phospholipids. The interaction leads to changes in membrane permeability, which can result in apoptosis.</p>Formula:C14H23NOPurezza:Min. 95%Colore e forma:White PowderPeso molecolare:221.34 g/molPemetrexed related impurity 2
<p>Pemetrexed related impurity 2 is a drug product that is an analytical impurity found in the metabolite of pemetrexed. It has been shown to be naturally occurring and is not toxic at high doses. This impurity has been synthesized as an impurity standard for HPLC. Pemetrexed related impurity 2 is used in research and development studies for drug development, such as pharmacopoeia testing for high purity standards.</p>Formula:C20H21N5O8Purezza:Min. 95%Peso molecolare:459.41 g/mol3-Amino-4-carbamoylpyrazole hemisulfate
CAS:<p>3-Amino-4-carbamoylpyrazole hemisulfate is a white to yellowish crystalline powder that is soluble in water and methanol. It is a condensation product of allopurinol and ethyl orthoformate with a molecular weight of 312.4. 3-Amino-4-carbamoylpyrazole hemisulfate can be used as an anti-inflammatory agent, but it has not been approved for medical use in the United States.</p>Formula:C4H6N4OH2O4SPurezza:Min. 95%Colore e forma:White PowderPeso molecolare:175.16 g/mol((2R,3S,4R,5R)-3,4-Dihydroxy-5-(6-oxo-1,6-dihydro-9H-purin-9-yl)tetrahydrofuran-2-yl)methyl isobutyrate
Purezza:98%Peso molecolare:338.322-Hydroxypyrimidine-5-carboxylic acid
CAS:Formula:C5H4N2O3Purezza:97%Colore e forma:SolidPeso molecolare:140.0982,4-Dichloro-5-fluoropyrimidine
CAS:Formula:C4HCl2FN2Purezza:97%Colore e forma:Solid, Chunks or Crystalline PowderPeso molecolare:166.962-Methyl-5-bromopyrimidine-4-carboxylic acid
CAS:Formula:C6H5BrN2O2Purezza:95%Colore e forma:SolidPeso molecolare:217.0225-Fluoropyrimidine-2-carboxylic acid
CAS:Formula:C5H3FN2O2Purezza:96%Colore e forma:SolidPeso molecolare:142.0892,4-DIAMINO-6-CHLORO-PYRIMIDINE-5-CARBONITRILE
CAS:Purezza:97%Colore e forma:SolidPeso molecolare:169.57000732′-O-Methylguanosine
CAS:Formula:C11H15N5O5Purezza:98%Colore e forma:Solid, White to almost white powderPeso molecolare:297.2714-Chloro-6-trifluoromethylpyrimidine
CAS:Formula:C5H2ClF3N2Purezza:97%Colore e forma:LiquidPeso molecolare:182.53N-{9-[(2R,3R,4R,5R)-5-{[bis(4-methoxyphenyl)(phenyl)methoxy]methyl}-3-fluoro-4-hydroxyoxolan-2-yl]-6-oxo-6,9-dihydro-1H-purin-2-yl}-2-methylpropanamide
CAS:Purezza:97%Peso molecolare:657.699Ethyl 2-hydroxypyrimidine-5-carboxylate
CAS:Formula:C7H8N2O3Purezza:97%Colore e forma:SolidPeso molecolare:168.15212-Oxa-2,8,10-triazatetradec-8-enoic acid, 3-carboxy-9-[[(1,1-dimethylethoxy)carbonyl]amino]-13,13-dimethyl-11-oxo-, 1-(9H-fluoren-9-ylmethyl) ester, (3S)-
CAS:Purezza:97%Peso molecolare:610.7080078(S)-3-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-6-(3-((2,2,4,6,7-pentamethyl-2,3-dihydrobenzofuran-5-yl)sulfonyl)guanidino)hexanoic acid
CAS:Purezza:95%Peso molecolare:662.79998784-Amino-1-((2R,3S,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidin-2(1H)-one
CAS:Formula:C9H13N3O5Purezza:98%Colore e forma:White to almost white powderPeso molecolare:243.2194-(tert-Butyl)-2-chloropyrimidine
CAS:Formula:C8H11ClN2Purezza:98%Colore e forma:No data available.Peso molecolare:170.64N-(1-((2R,4S,5R)-4-Hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-2-oxo-1,2-dihydropyrimidin-4-yl)acetamide
CAS:Formula:C11H15N3O5Purezza:98%Colore e forma:SolidPeso molecolare:269.257Adenosine-5′-monophosphate monohydrate
CAS:Formula:C10H16N5O8PPurezza:98%Colore e forma:SolidPeso molecolare:365.2391-(4-Chloro-3-(trifluoromethyl)phenyl)-3-(2-fluoro-4-hydroxyphenyl)urea
CAS:Purezza:98%Peso molecolare:348.67999272-Hydroxy-5-nitropyrimidine
CAS:Formula:C4H3N3O3Purezza:95%Colore e forma:SolidPeso molecolare:141.0864-Chloro-2-(methylthio)pyrimidine-5-carbonitrile
CAS:Formula:C6H4ClN3SPurezza:95%Colore e forma:Solid, Yellow powderPeso molecolare:185.633-Cyclopropyl-1-(2-fluoro-4-iodophenyl)-6-(methylamino)pyrimidine-2,4(1H,3H)-dione
CAS:Purezza:98%Peso molecolare:401.17999271-[(2S,3S,4R,5R)-3,4-bis(benzoyloxy)-5-(2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)-2-(iodomethyl)oxolan-2-yl]triaz-2-yn-2-ium-1-ide
CAS:Purezza:95%Peso molecolare:603.3289795(2R,3S,5R)-5-(6-Amino-9H-purin-9-yl)-2-(hydroxymethyl)tetrahydrofuran-3-ol
CAS:Formula:C10H13N5O3Purezza:95%Colore e forma:Solid, CrystallinePeso molecolare:251.2464,6-Dichloro-2-(methylthio)pyrimidine-5-carbaldehyde
CAS:Formula:C6H4Cl2N2OSPurezza:97%Colore e forma:SolidPeso molecolare:223.072-Chloro-5-methoxy-4-methylpyrimidine
CAS:Formula:C6H7ClN2OPurezza:98%Colore e forma:SolidPeso molecolare:158.59(2,4-Dioxo-3,4-dihydro-2 H -pyrimidin-1-yl)-acetic acid
CAS:Formula:C6H6N2O4Purezza:96%Colore e forma:SolidPeso molecolare:170.1245-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidine
CAS:Formula:C10H15BN2O2Purezza:95%Colore e forma:PowderPeso molecolare:206.05(4,6-Dimethyl-pyrimidin-2-yl)-hydrazine
CAS:Formula:C6H10N4Purezza:97%Colore e forma:SolidPeso molecolare:138.1744,6-Dichloropyrimidin-2(1H)-one
CAS:Formula:C4H2Cl2N2OPurezza:97%Colore e forma:SolidPeso molecolare:164.972-(Chloromethyl)pyrimidine hydrochloride
CAS:Formula:C5H6Cl2N2Purezza:95%Colore e forma:SolidPeso molecolare:165.024,5-Diaminopyrimidine
CAS:Formula:C4H6N4Purezza:95%Colore e forma:Solid, CrystallinePeso molecolare:110.12(4,6-Dimethyl-pyrimidin-2-yl)-(R)-pyrrolidin-3-yl-amine hydrochloride
CAS:Formula:C10H17ClN4Purezza:95%Colore e forma:SolidPeso molecolare:228.725,6-Dihydroxy-2-phenylpyrimidine-4-carboxylic acid
CAS:Formula:C11H8N2O4Purezza:95%Peso molecolare:232.1954-Chloro-6-methylthiopyrimidine
CAS:Formula:C5H5ClN2SPurezza:98%Colore e forma:SolidPeso molecolare:160.625-Bromo-2-chloro-4,6-dimethylpyrimidine
CAS:Formula:C6H6BrClN2Purezza:97%Colore e forma:Solid, Yellow powderPeso molecolare:221.48Ethyl 4-(2-chloropyrimidin-4-yl)benzoate
CAS:Formula:C13H11ClN2O2Purezza:96%Colore e forma:Liquid, No data available.Peso molecolare:262.692-((6-Chloro-3-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)methyl)benzonitrile
CAS:Formula:C13H10ClN3O2Purezza:98%Peso molecolare:275.69(2-(Azetidin-1-yl)pyrimidin-5-yl)boronic acid
CAS:Formula:C7H10BN3O2Purezza:98%Peso molecolare:178.99
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