Derivati delle Purine e Pirimidine
Le purine hanno una struttura biciclica, composta da un anello a sei membri fuso con un anello a cinque membri, entrambi contenenti atomi di azoto in posizioni chiave. I derivati delle purine, come l’adenina e la guanina, sono essenziali per la formazione del DNA e dell’RNA. Questi composti trovano applicazione terapeutica nei trattamenti contro il cancro e le malattie virali, inibendo la replicazione cellulare. Le pirimidine, invece, hanno una struttura monociclica a sei membri con due atomi di azoto. I loro derivati, come la citosina, la timina e l’uracile, sono anch’essi componenti fondamentali del DNA e dell’RNA e vengono utilizzati in chemioterapia e nei trattamenti antivirali.
Presso CymitQuimica, offriamo derivati delle purine e pirimidine per la ricerca in biologia molecolare, genomica e sviluppo di terapie innovative.
Trovati 8898 prodotti di "Derivati delle Purine e Pirimidine"
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CAS:Prodotto controllato<p>Applications Picornavirus replication inhibitor. Antiviral.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Kearns, G.L., J. Clin. Pharmacol., 39, 613 (1999), Schmidtke, M. et al.: Antiviral Res. 81, 56 (2009)<br></p>Formula:C18H18F3N3O3Colore e forma:NeatPeso molecolare:381.35Tenofovir Disoproxil Dimer
CAS:Prodotto controllato<p>Stability Very Hygroscopic and Temperature Sensitive<br>Applications Tenofovir Disoproxil impurity.<br>References Cheng, G., et al.: Chem. Res. Toxicol., 16, 145 (2003),<br></p>Formula:C39H60N10O20P2Colore e forma:White SolidPeso molecolare:1050.90N-Methyl Pemetrexed
CAS:Prodotto controllato<p>Impurity Pemetrexed EP Impurity A<br>Applications N-Methyl Pemetrexed (Pemetrexed EP Impurity A) is an impurity of Pemetrexed (P219500), an multitargeted antifolate that inhibits thymidylate synthase as well as other folate dependent enzymes.<br>References Kjell, D.P., et al.: Org. Proc. Res. Develop., 9, 738 (2005);<br></p>Formula:C21H23N5O6Colore e forma:NeatPeso molecolare:441.44Ethyl 2-(3-Cyano-4-isobutoxyphenyl)-4-methyl-5-thiazolecarboxylate
CAS:<p>Applications Ethyl 2-(3-Cyano-4-isobutoxyphenyl)-4-methyl-5-thiazolecarboxylate is an impurity of Febuxostat (F229000), a xanthine oxidase/xanthine dehydrogenase inhibitor. Used for treatment of hyperuricemia and chronic gout. 40-120 mg/day febuxostat was proven effective in lowering serum urate levels when administered to manage hyperuricemia in patients with gout.<br>References Vallu, V., et. al.: Anal. Chem. Indian J., 14, 339 (2014); Osada, Y., et al.: Eur. J. Pharmacol., 241, 183 (1993); Okamoto, K., et al.: J. Biol. Chem., 278, 1848 (2003); Mayer, M.D., et al.: Am. J. Therap., 12, 22 (2005); Tomlinson, B., et al.: Curr. Opin. Invest. Drugs, 6, 1168 (2005)<br></p>Formula:C18H20N2O3SColore e forma:NeatPeso molecolare:344.43Iopamidol-D3
CAS:Prodotto controllato<p>Applications Labelled nonionic radiocontrast medium. Diagnostic aid (radiopaque medium).<br>References Drayer, B., et al.: Am. J. Neuroradiol., 3, 59 (1982), Molyneux, A.J., et al.: Br. J. Radiol., 55, 117 (1982), Sovak, M., et al.: Radiology, 142, 115 (1982), Felder, E., et al.: Anal. Profiles Drug Subs., 17, 115 (1988),<br></p>Formula:C17H19D3I3N3O8Colore e forma:Off-WhitePeso molecolare:780.103-(Formylamino)-1H-pyrazole-4-carboxamide
CAS:Prodotto controllato<p>Impurity Allopurinol EP Impurity B / Allopurinol USP Related Compound B<br>Stability Hygroscopic<br>Applications 3-(Formylamino)-1H-pyrazole-4-carboxamide (Allopurinol EP Impurity B) is an impurity of Allopurinol (A547300) with inhibitory effects on human hypoxanthine phosphoribosyltransferase.<br>References Krenitzky, T.A. et al.: J. Biol. Chem., 244, 1263 (1969);<br></p>Formula:C5H6N4O2Colore e forma:White To Off-WhitePeso molecolare:154.1271,2,3,9-Tetrahydro-3-(1H-imidazol-1-ylmethyl)-9-methyl-4H-carbazol-4-one (Ondansetron Impurity G)
CAS:Prodotto controllato<p>Applications 1,2,3,9-Tetrahydro-3-(1H-imidazol-1-ylmethyl)-9-methyl-4H-carbazol-4-one is an metabolite of Ondansetron (O655000), is a selective 5-hydroxytryptamine3 (5-HT3) receptor antagonist that has been introduced to clinical practice as an antiemetic for cancer treatment-induced and anesthesia-related nausea and vomiting.<br>References Kris, M.G., et al.: J. Clin. Oncol., 6, 659 (1988), Faris, P..L., et al.: Lances, 355, 792 (2000), Ye, J.H., et al.: CNS Drug Reviews., 7, 199 (2001);<br></p>Formula:C17H17N3OColore e forma:White To Off-WhitePeso molecolare:279.348-Descarboxamido-8-cyano Temozolomide
CAS:Prodotto controllato<p>Applications 8-Descarboxamido-8-cyano Temozolomide is a useful synthetic intermediate in the synthesis of Temozolomide (T017775); an imidazotetrazine alkylating agent and antineoplastic.<br>References Newlands, E.S., et al.: Cancer Treat. Rev., 23, 35 (1997); Kim, C., et al.: J. Biol. Chem., 274, 1233 (1999); Hait, W., et al.: Cancer Res., 69, 1263 (2009); Wang, Y., et al.: J. Org. Chem., 62, 7288 (1997)<br></p>Formula:C6H4N6OColore e forma:Light Yellow To Light BrownPeso molecolare:176.142-Fluoroadenosine
CAS:Prodotto controllato<p>Applications 2-Fluoroadenosine is a fluorinated analog of Adenoside (A280400) nucleotide.<br>References Long, X., et al.: J. Pharmacol. Exper. Ther., 335, 781 (2010); Ham, M., et al.: J. Pharmacol. Exper. Ther., 335, 607 (2010);<br></p>Formula:C10H12FN5O4Colore e forma:NeatPeso molecolare:285.23N-Demethyl Ondansetron
CAS:<p>Applications A metabolite of Ondansetron (O655000).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Bayliss, M., et al: Xenobiotica, 24, 231 (1994), Atkins, W., et al.: J. Biol. Chem., 277, 33258 (2002), De Graaf, I., et al.: Drug Metab. Dispos., 30, 1129 (2002),<br></p>Formula:C17H17N3OColore e forma:White To BrownPeso molecolare:279.34Fmoc N-Hydroxysuccinimide Ester
CAS:<p>Stability Moisture Sensitive<br>Applications Used in conjunction with Isothiocyanate to conduct partial Edman Degradation on biologically active peptides.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Heidenreich, O., et al.: J. Biol. Chem., 269, 2131 (1994), Kothe, U., et al.: Anal. Biochem., 356, 148 (2006), Thakkar, A., et al.: Anal. Chem., 78, 5935 (2006),<br></p>Formula:C19H15NO5Colore e forma:NeatPeso molecolare:337.33Acetal
CAS:<p>Stability Volatile<br>Applications Acetal is a flavouring component of Baiju and Rum. It is also a useful reactant in organic synthesis.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Franitza, Laura, et al.: J. of Agric. and Food Chem., 64(47), 9041-9053 (2016);<br></p>Formula:C6H14O2Colore e forma:ColourlessPeso molecolare:118.17Sumatriptan
CAS:Prodotto controllato<p>Applications Sumatriptan is a serotonin 5HT1-receptor agonist.<br>References Humphrey, P.P.A., et al.: Brit. J. Pharmacol., 94, 1123 (1988); Doenicke, A., et al.: Lancet 1, 1309 (1988)<br></p>Formula:C14H21N3O2SColore e forma:White To Light YellowPeso molecolare:295.402-Methylimidazole
CAS:<p>Applications 2-Methylimidazole is a monomethylated imidazole that can be used as a building block in the preparation of a wide range of biologically active compounds. 2-Methylimidazole as well as other imidazoles can be use as catalyst for refolding of enhanced coloured fluorescent protein. 2-Methylimidazole has been identified as a byproduct of fermentation and is detected in foods and mainstream and side-stream tobacco smoke.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Shi, R. et al.: Arch. Biochem. Biophys., 459, 122 (2007); Chan, P.C. et al.: Arch. Toxicol., 82, 399 (2008); Nishie, K. et al.: Toxicol. Appl. Pharmacol., 14, 301 (1969);<br></p>Formula:C4H6N2Colore e forma:NeatPeso molecolare:82.106-Mercaptopurine-13C2,15N (major)
CAS:Prodotto controllato<p>Applications An immunosuppressive drug used to treat leukemia. It is also used for pediatric non-Hodgkin’s lymphoma, polycythemia vera, and psoriatic arthritis.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Naguib, F., et al.: Biochem. Pharmacol., 50, 1685 (1995), Zeng, H., et al.: Biochem. Pharmacol., 68, 911 (2004).<br></p>Formula:C313C2H4N315NSColore e forma:NeatPeso molecolare:155.166-Mercaptopurine Monohydrate
CAS:Prodotto controllato<p>Applications An immunosuppressive drug used to treat leukemia. It is also used for pediatric non-Hodgkin’s lymphoma, polycythemia vera, and psoriatic arthritis.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Zeng, H., et al.: Biochem. Pharmacol., 68, 911 (2004),<br></p>Formula:C5H4N4S·H2OColore e forma:YellowPeso molecolare:170.193-(Formylamino)-1H-pyrazole-4-carboxylic Acid Ethyl Ester
CAS:<p>Impurity Allopurinol EP Impurity E / Allopurinol USP Related Compound E<br>Applications 3-(Formylamino)-1H-pyrazole-4-carboxylic Acid Ethyl Ester (Allopurinol EP Impurity E) is an impurity of Allopurinol (A547300), a pyrazole derivative that has been shown to induce neoplasm immunogenicity.<br>References Nicolin, A. et al.: Cancer, Chemother. Rep., 57, 3 (1973); Bonmassar, E. et al.: Cancer Res., 35, 1957 (1975)<br></p>Formula:C7H9N3O3Colore e forma:WhitePeso molecolare:183.16Tenofovir
CAS:<p>Applications Tenofovir is an acyclic phosphonate nucleotide analogue and reverse transcriptase inhibitor. It is used as an anti-HIV agent. Antiviral.<br>References Shaw, J.-P., et al.: Pharm. Res., 14, 1824 (1997); Wyles, D., et al.: Clin Infect. Dis., 40, 174 (2005), Peng, J., et al.: J. Clin. Pharmacol., 46, 265 (2006), Seminari, E., et al.: J. Antimicrob. Chemother., 60, 831 (2007);<br></p>Formula:C9H14N5O4PColore e forma:White To Off-WhitePeso molecolare:287.21Urea-15N2
CAS:Prodotto controllato<p>Applications Labelled Urea. Physiological regulator of nitrogen excretion in mammals; synthesized in the liver as an end-product of protein catabolism and excreted in urine. Also occurs normally in skin. Emollient; diuretic.<br>References Demetriou, A., et al.: Science, 233, 1190 (1986), Aebischer, P., et al.: Nat. Med., 2, 696 (1996), Prakash, S., et al.: Biotechnol. Bioeng., 46, 621 (1995),<br></p>Formula:CH415N2OColore e forma:Off White SolidPeso molecolare:62.04
