Derivati delle Purine e Pirimidine
Le purine hanno una struttura biciclica, composta da un anello a sei membri fuso con un anello a cinque membri, entrambi contenenti atomi di azoto in posizioni chiave. I derivati delle purine, come l’adenina e la guanina, sono essenziali per la formazione del DNA e dell’RNA. Questi composti trovano applicazione terapeutica nei trattamenti contro il cancro e le malattie virali, inibendo la replicazione cellulare. Le pirimidine, invece, hanno una struttura monociclica a sei membri con due atomi di azoto. I loro derivati, come la citosina, la timina e l’uracile, sono anch’essi componenti fondamentali del DNA e dell’RNA e vengono utilizzati in chemioterapia e nei trattamenti antivirali.
Presso CymitQuimica, offriamo derivati delle purine e pirimidine per la ricerca in biologia molecolare, genomica e sviluppo di terapie innovative.
Trovati 8902 prodotti di "Derivati delle Purine e Pirimidine"
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3-Chlorodiphenylamine
CAS:Prodotto controllato<p>Applications 3-Chlorodiphenylamine (cas# 101-17-7) is a compound useful in organic synthesis.<br></p>Formula:C12H10ClNColore e forma:NeatPeso molecolare:203.675-Acetylamino-6-formylamino-3-methyluracil
CAS:Prodotto controllato<p>Applications Metabolite of Caffeine (C080100).<br>References Grant, D.M., et al.: Clin. Pharm. and Ther., 33, 591 (1983),<br></p>Formula:C8H10N4O4Colore e forma:Light Yellow SolidPeso molecolare:226.197-Hydroxy Memantine Hydrochloride
CAS:Prodotto controllato<p>Stability Hygroscopic<br>Applications A metabolite of Memantine (M218000), used for the treatment of neurological disorders.<br>References Eiichi, K., et al.: Chem. Pharm. Bull., 33, 4680 (1985),<br></p>Formula:C12H21NO·ClHColore e forma:NeatPeso molecolare:231.76Acetal
CAS:<p>Stability Volatile<br>Applications Acetal is a flavouring component of Baiju and Rum. It is also a useful reactant in organic synthesis.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Franitza, Laura, et al.: J. of Agric. and Food Chem., 64(47), 9041-9053 (2016);<br></p>Formula:C6H14O2Colore e forma:ColourlessPeso molecolare:118.177-Hydroxy DAMPA
CAS:Prodotto controllato<p>Stability Hygroscopic<br>Applications A metabolite of DAMPA.<br>References Bleyer, W., et al.: Cancer, 41, 36 ( 1978), Abelson, H., et al.: J. Clin. Oncol., 1, 208 (1983), Fabre, G., et al.: Biochem. Pharmacol., 35, 1325 (1986), Widemann, B., et al.: Clin. Chem., 45, 223 (1999),<br></p>Formula:C15H15N7O3Colore e forma:YellowPeso molecolare:341.324-Dimethylaminobutyraldehyde Diethyl Acetal
CAS:Prodotto controllato<p>Impurity Zolmitriptan USP Related Compound H<br>Applications 4-Dimethylaminobutyraldehyde Diethyl Acetal (Zolmitriptan USP Related Compound H) is used in the preparation of N,N-Dimethyltryptamines, 5-HT1D receptor agonists, for medicinal treatments such as antimigraine drugs.<br>References Chen, C. et al.: J. Org. Chem., 59, 3738 (1994);<br></p>Formula:C11H23NO2Colore e forma:NeatPeso molecolare:189.3N-[[[(1R)-2-(6-Amino-9H-purin-9-yl)-1-methylethoxy]methyl]hydroxyphosphinyl]-D-alanine 1-Methylethyl Ester
CAS:Prodotto controllato<p>Applications N-[[[(1R)-2-(6-Amino-9H-purin-9-yl)-1-methylethoxy]methyl]hydroxyphosphinyl]-D-alanine 1-Methylethyl Ester prorug of PMPA, phenyl monophosphoramidate, and is a Tenofovir (T018500) derivative, an acyclic phosphonate nucleotide analogue; reverse transcriptase inhibitor. Used as an anti-HIV agent. Antiviral.<br>References Shaw, J.-P., et al.: Pharm. Res., 14, 1824 (1997), Wyles, D., et al.: Clin Infect. Dis., 40, 174 (2005), Peng, J., et al.: J. Clin. Pharmacol., 46, 265 (2006), Seminari, E., et al.: J. Antimicrob. Chemother., 60, 831 (2007), Lee, W. et al.: Antimicrob. Agents Chemother., 49, 1898 (2005);<br></p>Formula:C15H25N6O5PPurezza:>85%Colore e forma:NeatPeso molecolare:400.37N-{4-[(4,6-Dimethylpyrimidin-2-yl)sulfamoyl]phenyl}-3-methylbenzamide
CAS:Peso molecolare:396.4700012207031MTIC-d3
CAS:Prodotto controllato<p>Applications A labelled metabolite of Temozolomide, an antineoplastic.<br></p>Formula:C5H5D3N6OColore e forma:Off White SolidPeso molecolare:171.18Methotrexate Triglutamate Trifluoroacetate
CAS:Prodotto controllato<p>Applications Methotrexate Triglutamate is a metabolite of Methotrexate (M260675); a folic acid antagonist, antineoplastic, and antirheumatic.<br>References Freeman, M.V., J. Pharmacol. Exp. Ther., 122, 154 (1958); Weinblass, M.E., et al.: N. Engl. J. Med., 312, 818 (1985)<br></p>Formula:C30H36N10O11xC2HF3O2Colore e forma:NeatPeso molecolare:712.67Ioxitalamic Acid-d4
CAS:Prodotto controllato<p>Applications A substituted 2,4,6-triiodobenzoic acid, an excellent contrast media for ventriculography, radiculography, lumbar myelography and x-rays of the cardiovascular system.<br>References Frocrain, L., et al.: Radiology, 170, 531 (1989), van Waes, P.F., et al.: Eur. J. Radiology, 9,179 (1989)<br></p>Formula:C12H7D4I3N2O5Colore e forma:White To Light BrownPeso molecolare:647.966-Mercaptopurine-13C2,15N (major)
CAS:Prodotto controllato<p>Applications An immunosuppressive drug used to treat leukemia. It is also used for pediatric non-Hodgkin’s lymphoma, polycythemia vera, and psoriatic arthritis.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Naguib, F., et al.: Biochem. Pharmacol., 50, 1685 (1995), Zeng, H., et al.: Biochem. Pharmacol., 68, 911 (2004).<br></p>Formula:C313C2H4N315NSColore e forma:NeatPeso molecolare:155.16Memantine Lactose Adduct
CAS:Prodotto controllato<p>Stability Hygroscopic<br>Applications A lactose adduct of Memantine (M218000). Intermediate in the synthesis of reducing carbohydrate Adamantane amines for use in treating Gram positive or Gram negative bacteria infections.<br>References Kustimur, et al.: Chinese Med. J., 116, 633 (2003),<br></p>Formula:C24H41NO10Colore e forma:NeatPeso molecolare:503.582-Amino-6-mercaptopurine-9-D-riboside Hydrate
CAS:<p>Stability Hygroscopic<br>Applications 2-Amino-6-mercaptopurine-9-D-riboside Hydrate (cas# 345909-25-3) is a compound useful in organic synthesis.<br></p>Formula:C10H13N5O4S·x(H2O)Colore e forma:Light Yellow PowderPeso molecolare:299.31N-Desacetyl 5-Azido Oseltamivir
CAS:Prodotto controllato<p>Applications Intermediate in the production of Oseltamivir. It is a COVID19-related research product.<br>References Williams, M., et al.: Bioorg. Med. Chem. Lett., 7, 1837 (1997),<br></p>Formula:C14H24N4O3Colore e forma:NeatPeso molecolare:296.373-(Formylamino)-1H-pyrazole-4-carboxylic Acid Ethyl Ester
CAS:<p>Impurity Allopurinol EP Impurity E / Allopurinol USP Related Compound E<br>Applications 3-(Formylamino)-1H-pyrazole-4-carboxylic Acid Ethyl Ester (Allopurinol EP Impurity E) is an impurity of Allopurinol (A547300), a pyrazole derivative that has been shown to induce neoplasm immunogenicity.<br>References Nicolin, A. et al.: Cancer, Chemother. Rep., 57, 3 (1973); Bonmassar, E. et al.: Cancer Res., 35, 1957 (1975)<br></p>Formula:C7H9N3O3Colore e forma:WhitePeso molecolare:183.16Tenofovir
CAS:<p>Applications Tenofovir is an acyclic phosphonate nucleotide analogue and reverse transcriptase inhibitor. It is used as an anti-HIV agent. Antiviral.<br>References Shaw, J.-P., et al.: Pharm. Res., 14, 1824 (1997); Wyles, D., et al.: Clin Infect. Dis., 40, 174 (2005), Peng, J., et al.: J. Clin. Pharmacol., 46, 265 (2006), Seminari, E., et al.: J. Antimicrob. Chemother., 60, 831 (2007);<br></p>Formula:C9H14N5O4PColore e forma:White To Off-WhitePeso molecolare:287.21Methotrexate-Cadaverine-Biotin Conjugate
Prodotto controllato<p>Applications Methotrexate-Cadaverine-Biotin Conjugate is biotin labelled Methotrexate. Methotrexate (M260675) is a folic acid antagonist and it is used as a antineoplastic and antirheumatic.<br>References Freeman, M.V., J. Pharmacol. Exp. Ther., 122, 154 (1958), Weinblass, M.E., et al.: N. Engl. J. Med., 312, 818 (1985),<br></p>Formula:C35H48N12O6SPurezza:>85%Colore e forma:NeatPeso molecolare:764.9Urea-15N2
CAS:Prodotto controllato<p>Applications Labelled Urea. Physiological regulator of nitrogen excretion in mammals; synthesized in the liver as an end-product of protein catabolism and excreted in urine. Also occurs normally in skin. Emollient; diuretic.<br>References Demetriou, A., et al.: Science, 233, 1190 (1986), Aebischer, P., et al.: Nat. Med., 2, 696 (1996), Prakash, S., et al.: Biotechnol. Bioeng., 46, 621 (1995),<br></p>Formula:CH415N2OColore e forma:Off White SolidPeso molecolare:62.04Methotrexate
CAS:<p>Stability Hygroscopic<br>Applications A Folic acid antagonist. Used as a antineoplastic and antirheumatic.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Freeman, M.V., J. Pharmacol. Exp. Ther., 122, 154 (1958), Weinblass, M.E., et al.: N. Engl. J. Med., 312, 818 (1985),<br></p>Formula:C20H22N8O5Colore e forma:Yellow To Dark YellowPeso molecolare:454.443-Nitro-L-tyrosine-d3
CAS:Prodotto controllato<p>Applications A labelled marker for peroxynitrite. Oxidant and cytotoxic agent.<br>References Sekiguchi, M., et al.: Brain Res., 978, 228 (2003), van den Tweel, E., et al.: J. Neurobiol., 167, 64 (2005), Shirakura, T., et al.: Biol. Pharm. Bull., 28, 1658 (2005),<br></p>Formula:C9D3H7N2O5Colore e forma:NeatPeso molecolare:229.2Tenofovir Disoproxil Isopropoxycarbonyl
CAS:<p>Stability Hygroscopic<br>Applications Tenofovir Disoproxil derivative as antiviral and antitumor agent.<br></p>Formula:C23H36N5O12PColore e forma:White SolidPeso molecolare:605.53(S)-4-(4-Aminobenzyl)-2-(1H)-oxazolidinone
CAS:Prodotto controllato<p>Impurity Zolmitriptan USP Related Compound G<br>Applications An intermediate of Zolmitriptan, as a novel inhibitor of the cytochrome P-450 enzyme aromatase. Zolmitriptan USP Related Compound G.<br>References Ahmed, S., et al.: Bioorg. Med. Chem. Lett., 5, 2789(1995), Ahmed, S., et al.: Drug. Des. Discov., 15, 239 (1998), Brodie, A., et al.: Steroids, 65, 171 (2000),<br></p>Formula:C10H12N2O2Colore e forma:NeatPeso molecolare:192.21Memantine Glycine
CAS:Prodotto controllato<p>Stability Hygroscopic<br>Applications An impurity of the antiparkinsonian and antispasmodic agent Memantine (M218000).<br>References Rystov, L. et al.: J. Pharmac. Biomed. Anal., 56, 887 (2011);<br></p>Formula:C14H23NO2Colore e forma:NeatPeso molecolare:237.341,3,7-Trimethyluric Acid-d3
CAS:Prodotto controllato<p>Stability Store in freezer<br>Applications A caffeine metabolite.<br>References Regal, K.A., et al.: J. of Chromatography B, 708, 75 (1998)<br></p>Formula:C82H3H7N4O3Colore e forma:NeatPeso molecolare:213.217-Methyl Memantine Hydrochloride
CAS:<p>Stability Hygroscopic<br>Applications 7-Methyl Memantine is an impurity of Memantine (HCl salt, M218000) which is used as an antiparkinsonian and antispasmodic.<br>References Rohde, H., et al.: Fortschr. Med., 100, 2023 (1982), Kornhuber, J., et al.: Eur. J. Pharmacol., 166, 589 (1989), Gortelmeyer, R. and Erbler, H.: Arzneimittel-Forsch., 42, 904 (1992)<br></p>Formula:C13H23N·ClHColore e forma:White SolidPeso molecolare:229.79Tenofovir Phosphate Diammonia Salt, >90%
CAS:Prodotto controllato<p>Applications Tenofovir Phosphate Diammonia Salt is a metabolite of Tenofovir (T018500), an acyclic phosphonate nucleotide analogue; reverse transcriptase inhibitor. Used as an anti-HIV agent. Antiviral.<br>References Michelson, A.M., et al.: Biochim. Biophys. Acta, 91, 1 (1964); Rosenberg, I., et al.: Collect. Czeck. Chem. Commun., 50, 1507 (1985); Shaw, J.-P., et al.: Pharm. Res., 14, 1824 (1997); Wyles, D., et al.: Clin Infect. Dis., 40, 174 (2005),; Peng, J., et al.: J. Clin. Pharmacol., 46, 265 (2006); Seminari, E., et al.: J. Antimicrob. Chemother., 60, 831 (2007)<br></p>Formula:C9H21N7O7P2Purezza:>90%Colore e forma:NeatPeso molecolare:401.25Tri-POC Tenofovir Dimer (>90%)
CAS:Prodotto controllato<p>Stability Very Hygroscopic<br>Applications Tri-POC Tenofovir Dimer is a dimer of Tenofovir Disoproxil (T018505), an acyclic phosphonate nucleotide analogue; reverse transcriptase inhibitor. Used as an anti-HIV agent. Antiviral. It is also used in the preparation of phosphocitrate for the treatment of rheumatoid and osteoarthritis in the elderly.<br>References Turhanen, P. et al.: J. Org. Chem., 72, 1468 (2007);<br></p>Formula:C34H52N10O17P2Purezza:>90%Colore e forma:White To Light BeigePeso molecolare:934.78N'-Formylkynurenine
CAS:<p>Stability Hygroscopic<br>Applications N'-Formylkynurenine is a photooxidation product of Tryptophan (T947200), and is also used as a photosensitizer of near-ultraviolet radiation by generating singlet oxygen and superoxide.<br>References Grossweiner, L.: Curr. Eye Res., 3, 137 (1984); Møller, I. & Kristensen, B.: Free Radical Bio. Med., 40, 430 (2006); Pileni, M., et al.: J. Phys. Chem., 80, 1804 (1976)<br></p>Formula:C11H12N2O4Colore e forma:Off White To Dark BeigePeso molecolare:236.22Tenofovir Isopropyl Ethyl Diester
CAS:Prodotto controllato<p>Stability Hygroscopic<br>Applications Tenofovir Disopropyl Ethyl Diester is an impurity of Tenofovir (T018500), an acyclic phosphonate nucleotide analogue and reverse transcriptase inhibitor. Used as an anti-HIV agent. Antiviral.<br>References Shaw, J.-P., et al.: Pharm. Res., 14, 1824 (1997), Wyles, D., et al.: Clin Infect. Dis., 40, 174 (2005), Peng, J., et al.: J. Clin. Pharmacol., 46, 265 (2006), Seminari, E., et al.: J. Antimicrob. Chemother., 60, 831 (2007),<br></p>Formula:C18H28N5O10PColore e forma:NeatPeso molecolare:505.42(R)-9-[2-(Diethylphosphonomethoxy)propyl] Adenine
CAS:Prodotto controllato<p>Applications A acyclic phosphonate nucleotide.<br></p>Formula:C13H22N5O4PColore e forma:White SolidPeso molecolare:343.32Urea-urethane Compound (~85%)
CAS:Prodotto controllato<p>Applications Urea-urethane Compound is a reaction product of 4,4'-sulfonylbis[benzenamine] and 2,4-TDI.<br></p>Formula:C42H36N6O8SPurezza:~80%Colore e forma:NeatPeso molecolare:784.84Tri-o-tolyl-Phosphine Oxide
CAS:Prodotto controllato<p>Impurity Eletriptan Impurity 14<br>Applications Tri-o-tolyl-Phosphine Oxide (Eletriptan Impurity 14) is an impurity of Eletriptan, a selective serotonin 5-HT1B and 5-HT1D receptor agonist and used to treat migraines.<br>References Willems, E., et al.: Arch. Pharmacol., 358, 212 (1998); Napier, C., et al.: Eur. J. Pharmacol., 368, 259 (1999); Goadsby, P.J., et al.: Neurology, 54, 156 (2000)<br></p>Formula:C21H21OPColore e forma:NeatPeso molecolare:320.365Lifitegrast
CAS:Prodotto controllato<p>Applications Lifitegrast is used for the treatment of signs and symptons of dry eye diseases. It also Inhibites corneal inflammation that is capable of causing pains, blurred vision and ocular discomfort in sufferer.<br>References Holland, E. J., et al.: Curr. Med. Res. Opin., 32, 1759 (2016); Sun, Y., et al.: J. Ocul. Pharmacol. Ther., 29, 395 (2013);<br></p>Formula:C29H24Cl2N2O7SColore e forma:White To Off-WhitePeso molecolare:615.481Pemetrexed-13C5 Disodium Heptahydrate
CAS:Prodotto controllato<p>Applications Pemetrexed-13C5 Disodium Salt, is the labeled analogue of Pemetrexed Disodium (P219500), used as Antineoplastic agent.<br>References McDonald, A.C., et al.: Clin. Cancer Res., 4, 605 (1998), John, W., et al.: Cancer, 88, 1807 (2000), Miller, K.D., et al.: Ann. Oncol., 11, 101 (2000),<br></p>Formula:C1513C5H19N5Na2O6•7(H2O)Colore e forma:Off-WhitePeso molecolare:476.3471802D-Neopterin
CAS:Prodotto controllato<p>Stability Hygroscopic<br>Applications Precursor in the biosynthesis of Biopterin. First isolated from the pupae of bees.<br>References Kobashi, I., et al.: Agric. Biol. Chem., 35, 47 (1971), Fukushima, S., et al.: J. Biol. Chem., 247, 4549 (1972),<br></p>Formula:C9H11N5O4Colore e forma:NeatPeso molecolare:253.21Methyl 2-[3-Cyano-4-(2-methylpropoxy)phenyl]-4-methylthiazole-5-carboxylate
CAS:Prodotto controllatoFormula:C17H18N2O3SColore e forma:NeatPeso molecolare:330.4DAMPA-d3
CAS:Prodotto controllato<p>Applications Labelled Methotrexate (M260675) analog. DAMPA is an antitumor agent.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Martinelli, J.E., et al.: J. Med. Chem., 22, 869 (1979);<br></p>Formula:C152H3H12N7O2Colore e forma:Dark OrangePeso molecolare:328.341-Methyl Xanthine-d3
CAS:Prodotto controllato<p>Applications A labelled metabolite of Theophylline.<br>References ottrup, A., et al.: Pharmacol. Toxicol., 67, 340 (1990), El-Kadi, A., et al.: Drug Metab. Dispos., 28, 1112 (2000), Kim, S., et al.: J. Med. Chem., 45, 2131 ( 2002), Hansel, T., et al.: Drugs Today, 40, 55 (2004),<br></p>Formula:C62H3H3N4O2Colore e forma:NeatPeso molecolare:169.16Tetrabenazine-d6
CAS:Prodotto controllato<p>Applications Labelled Tetrabenazine. Dopamine depleting agent. An antidyskinetic; antipsychotic.<br>References Schwartz, et al.: Biochem. Pharmacol., 15, 645 (1966), Janovic, J., et al.: Ann. Neurol., 11, 41 (1982), Janovic, J., et al.: Neurology, 38, 391 (1988),<br></p>Formula:C19H21D6NO3Colore e forma:NeatPeso molecolare:323.462-[[3-[2-(Dimethylamino)ethyl]-1H-indol-5-yl]methyl] Sumatriptan (>90%)
CAS:Prodotto controllato<p>Impurity Sumatriptan EP Impurity A<br>Stability Light Sensitive<br>Applications 2-[[3-[2-(dimethylamino)ethyl]-1H-indol-5-yl]methyl] Sumatriptan Succinate (Sumatriptan EP Impurity A) is an impurity of Sumatriptan (S810000), a serotonin 5HT-1-receptor agonist.<br>References Skwierawska, A.. et al.: Poish. J. Chem., 77, 329 (2003);<br></p>Formula:C27H37N5O2SColore e forma:Off White SolidPeso molecolare:495.68Methotrexate-d3 Diglutamate Trifluoroacetate
CAS:Prodotto controllato<p>Applications Methotrexate-d3 Diglutamate is the isotope labelled analog of Methotrexate Diglutamate (M260720); a metabolite of Methotrexate (M260675) which is a folic acid antagonist, antineoplastic, and antirheumatic.<br>References Freeman, M.V., J. Pharmacol. Exp. Ther., 122, 154 (1958); Weinblass, M.E., et al.: N. Engl. J. Med., 312, 818 (1985)<br></p>Formula:C25H26D3N9O8•x(C2HF3O2)•xH2SO4Colore e forma:NeatPeso molecolare:586.58114029815-Diazoimidazole-4-carboxamide
CAS:Prodotto controllato<p>Impurity Temozolomide USP Related Compound A<br>Applications Temozolomide USP Related Compound A<br></p>Formula:C4H3N5OColore e forma:NeatPeso molecolare:137.103,4-Dihydro Naratriptan Oxalate
CAS:Prodotto controllato<p>Stability Hygroscopic<br>Applications 3,4-Dihydro Naratriptan Oxalate is the basic form of 3,4-Dihydro Naratriptan(D449205); it is an impurity of Naratriptan (N378730), It is a triptan drug and is used for the treatment of migraine headaches.<br>References Dulery, B.D., et al.: J. Pharm. Biomed. Anal., 15, 1009 (1997), Havanka, H., et al.: Clin. Ther., 22, 970 (2000),<br></p>Formula:C17H23N3O2S·C2H2O4Colore e forma:White To Light YellowPeso molecolare:333.45 + 90.036,6'-Binicotinic Acid
CAS:Prodotto controllato<p>Applications A Nicotinic acid (N429250) derivative for treatment of hypercholesterolemia and hyperlipidemia and cardiovascular disease.<br>References Hales, N.J., et al.: J. Med. Chem., 36, 3853 (1993),<br></p>Formula:C12H8N2O4Colore e forma:NeatPeso molecolare:244.20
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