Derivati delle Purine e Pirimidine
Le purine hanno una struttura biciclica, composta da un anello a sei membri fuso con un anello a cinque membri, entrambi contenenti atomi di azoto in posizioni chiave. I derivati delle purine, come l’adenina e la guanina, sono essenziali per la formazione del DNA e dell’RNA. Questi composti trovano applicazione terapeutica nei trattamenti contro il cancro e le malattie virali, inibendo la replicazione cellulare. Le pirimidine, invece, hanno una struttura monociclica a sei membri con due atomi di azoto. I loro derivati, come la citosina, la timina e l’uracile, sono anch’essi componenti fondamentali del DNA e dell’RNA e vengono utilizzati in chemioterapia e nei trattamenti antivirali.
Presso CymitQuimica, offriamo derivati delle purine e pirimidine per la ricerca in biologia molecolare, genomica e sviluppo di terapie innovative.
Trovati 8902 prodotti di "Derivati delle Purine e Pirimidine"
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6-METHYL-N1-(3-METHYL-1-(6-(METHYLAMINO)PYRIMIDIN-4-YL)-1H-PYRAZOL-5-YL)BENZENE-1,3-DIAMINE
CAS:Purezza:95.0%Peso molecolare:309.37701416015625Pemetrexed Sodium Methyl Ester
Prodotto controllato<p>Applications Pemetrexed Sodium Methyl Ester is an impurity of Pemetrexed(P219550). Pemetrexed Disodium Heptahydrate is an chemotherapy drug for the treatment of pleural mesothelioma and non-small cell lung cancer. Pemetrexed Disodium Heptahydrate exhibit inhibitory activities towards thymidylate synthase as well as other folate dependent enzymes.<br>References Vogelzang, N.J., et al.: J. Clin. Oncol., 21,2636 (2003); Paz-Ares, L., et al.: Lancet. Oncol., 13, 247 (2012);<br></p>Formula:C21H22N5NaO6Colore e forma:NeatPeso molecolare:463.419(S)-4-(4-Aminobenzyl)-2-(1H)-oxazolidinone
CAS:Prodotto controllato<p>Impurity Zolmitriptan USP Related Compound G<br>Applications An intermediate of Zolmitriptan, as a novel inhibitor of the cytochrome P-450 enzyme aromatase. Zolmitriptan USP Related Compound G.<br>References Ahmed, S., et al.: Bioorg. Med. Chem. Lett., 5, 2789(1995), Ahmed, S., et al.: Drug. Des. Discov., 15, 239 (1998), Brodie, A., et al.: Steroids, 65, 171 (2000),<br></p>Formula:C10H12N2O2Colore e forma:NeatPeso molecolare:192.21Tenofovir Alafenamide-d5 (Diastereomers)
CAS:Prodotto controllatoFormula:C212H5H24N6O5PColore e forma:NeatPeso molecolare:481.50Tenofovir Disoproxil Isopropoxycarbonyl
CAS:<p>Stability Hygroscopic<br>Applications Tenofovir Disoproxil derivative as antiviral and antitumor agent.<br></p>Formula:C23H36N5O12PColore e forma:White SolidPeso molecolare:605.53Ethyl 2-(2-(methylamino)pyrimidin-4-yl)-1H-indole-5-carboxylate
CAS:Purezza:95.0%Colore e forma:Liquid, No data available.Peso molecolare:296.3299865722656(S)-5-(1,3-Bis(tert-butoxycarbonyl)guanidino)-2-((tert-butoxycarbonyl)amino)pentanoic acid
CAS:Formula:C21H38N4O8Purezza:95.0%Colore e forma:Liquid, No data available.Peso molecolare:474.555N-Hydroxymethyl Sumatriptan
CAS:Prodotto controllato<p>Applications Hydroxymethyl Sumatriptan is an analog of Sumatriptan (S810000), a serotonin 5HT1-receptor agonist.<br>References Humphrey, P.P.A., et al.: Brit. J. Pharmacol., 94, 1123 (1988), Doenicke, A., et al.: Lancet 1, 1309 (1988),<br></p>Formula:C15H23N3O3SColore e forma:NeatPeso molecolare:325.435-Amino-N1-methyl-1H-imidazole-1,4-dicarboxamide
CAS:Prodotto controllato<p>Applications 5-Amino-N1-methyl-1H-imidazole-1,4-dicarboxamide is a metabolite of Temozolomide (T017775); an imidazotetrazine alkylating agent and antineoplastic.<br>References Newlands, E.S., et al.: Cancer Treat. Rev., 23, 35 (1997); Kim, C., et al.: J. Biol. Chem., 274, 1233 (1999); Hait, W., et al.: Cancer Res., 69, 1263 (2009); Wang, Y., et al.: J. Org. Chem., 62, 7288 (1997)<br></p>Formula:C6H9N5O2Colore e forma:Off-WhitePeso molecolare:183.17Ethyl-S-(+)-Clopidogrel Sulfate
CAS:Prodotto controllato<p>Stability Very Hygroscopic<br>Applications Ethyl-(S)-(+)-Clopidogrel Sulfate is an analogue of S-(+)-Clopidogrel Hydrogen Sulfate (C587250) which is used as an antithrombotic.<br>References Mills, D.C.B., et al.: Arterioscler. Thromb., 12, 430 (1992), Feuerstein, G., et al.: Exp. Opin. Invest. Drugs, 4, 425 (1995)<br></p>Formula:C17H20ClNO6S2Colore e forma:White To Off-WhitePeso molecolare:433.935-((tert-Butoxycarbonyl)amino)pyrimidine-2-carboxylic acid
CAS:Purezza:95%Peso molecolare:239.23100280761724-Chloro Kynurenine-13C2,15N
CAS:Prodotto controllato<p>Applications 7-Cl-kynurenic acid (7-Cl-KYNA) is a potent, selective antagonist of the NMDA/glycine receptor but penetrates poorly through the blood-brain barrier. Its prodrug, L-4-Cl-kynurenine (4-Cl-KYN), readily enters the brain from the circulation and provides antiexcitotoxic neuroprotection after systemic application.<br>References Leeson, P., et al.: J. Med. Chem., 37, 4053 (1994), Hilmas, C., et al.: J. Neurosci., 2001, 21, 7463 (2001), Palmer, G., et al.: Curr. Drug Targets, 2, 241 (2001), Wu, H., et al.: Exp. Neurol., 177, 222 (2002),<br></p>Formula:C813C2H11ClN15NO3Colore e forma:NeatPeso molecolare:245.64Uridine-3'-monophosphate disodium salt
CAS:Purezza:99.0%Colore e forma:SolidPeso molecolare:368.1449890136719N,N'-Di-Boc-guanidine
CAS:Purezza:99.0%Colore e forma:Solid, Crystalline Powder or PowderPeso molecolare:259.3059997558594Methotrexate
CAS:<p>Stability Hygroscopic<br>Applications A Folic acid antagonist. Used as a antineoplastic and antirheumatic.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Freeman, M.V., J. Pharmacol. Exp. Ther., 122, 154 (1958), Weinblass, M.E., et al.: N. Engl. J. Med., 312, 818 (1985),<br></p>Formula:C20H22N8O5Colore e forma:Yellow To Dark YellowPeso molecolare:454.444-Chloro-2-methylpyrimidine-5-carbonitrile
CAS:Purezza:95.0%Colore e forma:SolidPeso molecolare:153.570007324218751-((2R,3R,4S,5S)-3,5-DIFLUORO-4-HYDROXY-5-(HYDROXYMETHYL)TETRAHYDROFURAN-2-YL)PYRIMIDINE-2,4(1H,3H)-DIONE
Purezza:90.0%Peso molecolare:264.18499755859375Ref: 10-F531024
1gPrezzo su richiesta100mgPrezzo su richiesta250mgPrezzo su richiesta500mgPrezzo su richiesta4-Acetylamino-3-hydroxybenzoic Acid Ethyl Ester, 100 mg
CAS:<p>Impurity Oseltamivir EP Impurity D<br>Applications 4-Acetylamino-3-hydroxybenzoic Acid Ethyl Ester (Oseltamivir EP Impurity D) is an impurity in the antiviral drug Oseltamivir (O700100).<br></p>Formula:C11N13NO4Colore e forma:NeatPeso molecolare:223.23Urea-15N2
CAS:Prodotto controllato<p>Applications Labelled Urea. Physiological regulator of nitrogen excretion in mammals; synthesized in the liver as an end-product of protein catabolism and excreted in urine. Also occurs normally in skin. Emollient; diuretic.<br>References Demetriou, A., et al.: Science, 233, 1190 (1986), Aebischer, P., et al.: Nat. Med., 2, 696 (1996), Prakash, S., et al.: Biotechnol. Bioeng., 46, 621 (1995),<br></p>Formula:CH415N2OColore e forma:Off White SolidPeso molecolare:62.04(S)-Tenofovir Disoproxil Fumarate
CAS:Prodotto controllato<p>Impurity Tenofovir Disoproxil USP Related Compound A<br>Applications The S-enantiomeric impurity of the antiviral Tenofovir Disoproxil Fumarate (T018505(P)), which is an acyclic phosphonate nucleotide analogue; reverse transcriptase inhibitor and used as an anti-HIV agent.Tenofovir Disoproxil USP Related Compound A.<br>References Shaw, J. P., et al.: Pharm. Res., 14, 1824 (1997), Wyles, D., et al.: Clin Infect. Dis., 40, 174 (2005), Peng, J., et al.: J. Clin. Pharmacol., 46, 265 (2006), Seminari, E., et al.: J. Antimicrob. Chemother., 60, 831 (2007)<br></p>Formula:C19H30N5O10P·C4H4O4Colore e forma:White SolidPeso molecolare:635.523-Nitro-L-tyrosine-d3
CAS:Prodotto controllato<p>Applications A labelled marker for peroxynitrite. Oxidant and cytotoxic agent.<br>References Sekiguchi, M., et al.: Brain Res., 978, 228 (2003), van den Tweel, E., et al.: J. Neurobiol., 167, 64 (2005), Shirakura, T., et al.: Biol. Pharm. Bull., 28, 1658 (2005),<br></p>Formula:C9D3H7N2O5Colore e forma:NeatPeso molecolare:229.24-[6-(4-Methoxy-phenyl)-pyridin-3-yl]-pyrimidin-2-ylamine
Purezza:95.0%Peso molecolare:278.31500244140625Paraquat-d8 Dichloride
CAS:Prodotto controllato<p>Stability Hygroscopic<br>Applications Labelled Paraquat Dichloride, a commonly used heribicide. Paraquat Dichloride is a fast-acting and non-selective viologen derivative that kills green plant tissue on contact. Studies suggest that there might be a possible link between Paraquat Dichloride and the development of Parkinson’s disease.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Heylings, J.R. et al.: Toxicology, 241, 1 (2007); Wibawa, W. et al.: Int. J. Agric. Biol., 11, 145 (2009); Franco, R. et al.: Chem.-Biol. Inter., 188, 289 (2010);<br></p>Formula:C122H8H6N2·2ClColore e forma:ColourlessPeso molecolare:265.21Memantine Glycine
CAS:Prodotto controllato<p>Stability Hygroscopic<br>Applications An impurity of the antiparkinsonian and antispasmodic agent Memantine (M218000).<br>References Rystov, L. et al.: J. Pharmac. Biomed. Anal., 56, 887 (2011);<br></p>Formula:C14H23NO2Colore e forma:NeatPeso molecolare:237.34Memantine Hydrochloride
CAS:Prodotto controllato<p>Stability Hygroscopic<br>Applications Used as an antiparkinsonian and antispasmodic.<br>References Rohde, H., et al.: Fortschr. Med., 100, 2023 (1982), Kornhuber, J., et al.: Eur. J. Pharmacol., 166, 589 (1989), Gortelmeyer, R. and Erbler, H.: Arzneimittel-Forsch., 42, 904 (1992)<br></p>Formula:C12H21N·ClHColore e forma:White To Off-WhitePeso molecolare:215.76Tenofovir
CAS:<p>Applications Tenofovir is an acyclic phosphonate nucleotide analogue and reverse transcriptase inhibitor. It is used as an anti-HIV agent. Antiviral.<br>References Shaw, J.-P., et al.: Pharm. Res., 14, 1824 (1997); Wyles, D., et al.: Clin Infect. Dis., 40, 174 (2005), Peng, J., et al.: J. Clin. Pharmacol., 46, 265 (2006), Seminari, E., et al.: J. Antimicrob. Chemother., 60, 831 (2007);<br></p>Formula:C9H14N5O4PColore e forma:White To Off-WhitePeso molecolare:287.21Methotrexate-Cadaverine-Biotin Conjugate
Prodotto controllato<p>Applications Methotrexate-Cadaverine-Biotin Conjugate is biotin labelled Methotrexate. Methotrexate (M260675) is a folic acid antagonist and it is used as a antineoplastic and antirheumatic.<br>References Freeman, M.V., J. Pharmacol. Exp. Ther., 122, 154 (1958), Weinblass, M.E., et al.: N. Engl. J. Med., 312, 818 (1985),<br></p>Formula:C35H48N12O6SPurezza:>85%Colore e forma:NeatPeso molecolare:764.94-(Tert-butyl)-N-(4-(N-(2,6-dimethylpyrimidin-4-yl)sulfamoyl)phenyl)benzamide
CAS:Purezza:98%Peso molecolare:438.549987792968753-(Formylamino)-1H-pyrazole-4-carboxylic Acid Ethyl Ester
CAS:<p>Impurity Allopurinol EP Impurity E / Allopurinol USP Related Compound E<br>Applications 3-(Formylamino)-1H-pyrazole-4-carboxylic Acid Ethyl Ester (Allopurinol EP Impurity E) is an impurity of Allopurinol (A547300), a pyrazole derivative that has been shown to induce neoplasm immunogenicity.<br>References Nicolin, A. et al.: Cancer, Chemother. Rep., 57, 3 (1973); Bonmassar, E. et al.: Cancer Res., 35, 1957 (1975)<br></p>Formula:C7H9N3O3Colore e forma:WhitePeso molecolare:183.163,5,3',5'-Tetraiodo Thyrolactic Acid (~90%)
CAS:Prodotto controllato<p>Stability Hygroscopic, Temperature sensitive<br>Applications 3,5,3',5'-Tetraiodo Thyrolactic Acid is a thyroid hormone analogue. A Thyroxine (T425600) analogue.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Horst, C., et al.: Biochem. J., 261, 945 (1989); Kvetny, J., et al.: Horm. Metab. Res., 24, 322 (1992); Yamauchi, K., et al.: J. Biol. Chem., 274, 8460 (1999); Davis, P., et al.: J. Endocrinol. Invest., 25, 377 (2002);<br></p>Formula:C15H10I4O5Purezza:~90%Colore e forma:BeigePeso molecolare:777.85Ref: 10-F538150
1gPrezzo su richiesta100mgPrezzo su richiesta250mgPrezzo su richiesta500mgPrezzo su richiesta6-Methyl Nicotinic Acid
CAS:Prodotto controllato<p>Applications A degradation product of Nicotinic acid (N429250). An impurity of Nicotinic acid.<br>References Ensign, J., et al.: Biol. Chem., 239, 2285 (1964), Houghton, C., et al.: Biochem. J., 130, 879 (1972),<br></p>Formula:C7H7NO2Colore e forma:NeatPeso molecolare:137.145-cyclopropyl-N-(diaminomethylidene)-1-(quinolin-5-yl)-1H-pyrazole-4-carboxamide
CAS:Purezza:98%Peso molecolare:320.3559875488281Ref: 10-F601143
1gPrezzo su richiesta5gPrezzo su richiesta100mgPrezzo su richiesta250mgPrezzo su richiesta500mgPrezzo su richiesta2-Amino-6-mercaptopurine-9-D-riboside Hydrate
CAS:<p>Stability Hygroscopic<br>Applications 2-Amino-6-mercaptopurine-9-D-riboside Hydrate (cas# 345909-25-3) is a compound useful in organic synthesis.<br></p>Formula:C10H13N5O4S·x(H2O)Colore e forma:Light Yellow PowderPeso molecolare:299.31N-Desacetyl 5-Azido Oseltamivir
CAS:Prodotto controllato<p>Applications Intermediate in the production of Oseltamivir. It is a COVID19-related research product.<br>References Williams, M., et al.: Bioorg. Med. Chem. Lett., 7, 1837 (1997),<br></p>Formula:C14H24N4O3Colore e forma:NeatPeso molecolare:296.374-(3,4-dimethylphenyl)-6-(4-fluorophenyl)pyrimidin-2-amine
CAS:Purezza:95.0%Peso molecolare:293.34500122070314-(3,4-dimethylphenyl)-6-(3-methoxyphenyl)pyrimidin-2-amine
CAS:Purezza:95.0%Peso molecolare:305.3810119628906N'-Methyl-N,N-diphenylurea
CAS:<p>Impurity Temozolomide USP Related Compound B<br>Applications N'-Methyl-N,N-diphenylurea is used in the stabilization of thermal propellants. Temozolomide USP Related Compound B.<br>References Bohn, M. et al.: Prop. Exp. Pyro.,et al.: 19, 266 (1994); Muthurajan, H. et al.: J. Hazard. Mat., 133, 30 (2006);<br></p>Formula:C14H14N2OColore e forma:NeatPeso molecolare:226.276-Mercaptopurine Monohydrate
CAS:Prodotto controllato<p>Applications An immunosuppressive drug used to treat leukemia. It is also used for pediatric non-Hodgkin’s lymphoma, polycythemia vera, and psoriatic arthritis.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Zeng, H., et al.: Biochem. Pharmacol., 68, 911 (2004),<br></p>Formula:C5H4N4S·H2OColore e forma:YellowPeso molecolare:170.19Memantine Lactose Adduct
CAS:Prodotto controllato<p>Stability Hygroscopic<br>Applications A lactose adduct of Memantine (M218000). Intermediate in the synthesis of reducing carbohydrate Adamantane amines for use in treating Gram positive or Gram negative bacteria infections.<br>References Kustimur, et al.: Chinese Med. J., 116, 633 (2003),<br></p>Formula:C24H41NO10Colore e forma:NeatPeso molecolare:503.58N-Desmethyl Zolmitriptan
CAS:<p>Impurity Zolmitriptan USP Related Compound A<br>Stability Hygroscopic<br>Applications A metabolite of Zolmitriptan (Z639000). Zolmitriptan USP Related Compound A.<br>References Chen, J., et al.: J. Pharm. Biomed. Anal., 35, 639 (2004), Srinivasu, M., et al.: J. Pharm. Biomed. Anal., 37, 453 (2005),<br></p>Formula:C15H19N3O2Colore e forma:NeatPeso molecolare:273.33
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