Derivati delle Purine e Pirimidine
Le purine hanno una struttura biciclica, composta da un anello a sei membri fuso con un anello a cinque membri, entrambi contenenti atomi di azoto in posizioni chiave. I derivati delle purine, come l’adenina e la guanina, sono essenziali per la formazione del DNA e dell’RNA. Questi composti trovano applicazione terapeutica nei trattamenti contro il cancro e le malattie virali, inibendo la replicazione cellulare. Le pirimidine, invece, hanno una struttura monociclica a sei membri con due atomi di azoto. I loro derivati, come la citosina, la timina e l’uracile, sono anch’essi componenti fondamentali del DNA e dell’RNA e vengono utilizzati in chemioterapia e nei trattamenti antivirali.
Presso CymitQuimica, offriamo derivati delle purine e pirimidine per la ricerca in biologia molecolare, genomica e sviluppo di terapie innovative.
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6-Methyl-5-((3-(2-(methylthio)pyrimidin-4-yl)pyridin-2-yl)oxy)naphthalen-1-amine
CAS:Purezza:98%Peso molecolare:374.4599914550781Ref: 10-F634143
1gPrezzo su richiesta50mg469,00€100mg764,00€250mgPrezzo su richiesta500mgPrezzo su richiesta5-Ethyl-2-methylpyridine(5-Ethyl-2-picoline)
CAS:<p>Applications Perfume composition.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Hansen, B., et al.: Environ. Toxicol. Chem., 18, 772 (1999),<br></p>Formula:C8H11NColore e forma:ColourlessPeso molecolare:121.18D-Neopterin
CAS:Prodotto controllato<p>Stability Hygroscopic<br>Applications Precursor in the biosynthesis of Biopterin. First isolated from the pupae of bees.<br>References Kobashi, I., et al.: Agric. Biol. Chem., 35, 47 (1971), Fukushima, S., et al.: J. Biol. Chem., 247, 4549 (1972),<br></p>Formula:C9H11N5O4Colore e forma:NeatPeso molecolare:253.215,6-Dihydro Uracil-13C,15N2
CAS:<p>Applications Isotope Labelled 5,6-Dihydro Uracil is a degradation product of DNA and was used in mass spectrometric studies of cellular DNA damage.<br>References Nelson, V.C., et al.: J. Label. Com. Radiopharma., 38, 713 (1996)<br></p>Formula:C313CH615N2O2Colore e forma:Off-White To BeigePeso molecolare:117.082-(5-amino-3-cyclopropyl-1H-pyrazol-1-yl)-5,6-dimethylpyrimidin-4(3H)-one
CAS:Purezza:95.0%Peso molecolare:245.28599548339844Tetrabenazine-d6
CAS:Prodotto controllato<p>Applications Labelled Tetrabenazine. Dopamine depleting agent. An antidyskinetic; antipsychotic.<br>References Schwartz, et al.: Biochem. Pharmacol., 15, 645 (1966), Janovic, J., et al.: Ann. Neurol., 11, 41 (1982), Janovic, J., et al.: Neurology, 38, 391 (1988),<br></p>Formula:C19H21D6NO3Colore e forma:NeatPeso molecolare:323.462-[[3-[2-(Dimethylamino)ethyl]-1H-indol-5-yl]methyl] Sumatriptan (>90%)
CAS:Prodotto controllato<p>Impurity Sumatriptan EP Impurity A<br>Stability Light Sensitive<br>Applications 2-[[3-[2-(dimethylamino)ethyl]-1H-indol-5-yl]methyl] Sumatriptan Succinate (Sumatriptan EP Impurity A) is an impurity of Sumatriptan (S810000), a serotonin 5HT-1-receptor agonist.<br>References Skwierawska, A.. et al.: Poish. J. Chem., 77, 329 (2003);<br></p>Formula:C27H37N5O2SColore e forma:Off White SolidPeso molecolare:495.68Uric Acid
CAS:<p>Applications Uric Acid is a heterocyclcic compound that is created when purine nucleotides are broken down of by the human body. High blood concetration of Uric Acid is known as hyperuricemia and is often associated with a wide range of disorders and medical conditions such as gout, diabetes and metabolic syndrome. Uric acid may be a marker of oxidative stress and may have a potential therapeutic role as an antioxidant.<br>References Heinig, M. et al.: Cle. Clin. J. Med., 73, 1059 (2006); Glantzounis, G.K. et al.: Curr. Pharmac. Des., 11, 4145 (2005); Dehghan, A. et al.: Diab. Care, 31, 361 (2008); Nakagawa, T. et al.: Am. J. Physiol. Renal Physiol., 290, F625 (2006);<br></p>Formula:C5H4N4O3Colore e forma:NeatPeso molecolare:168.11Chloromethyl Isopropyl Carbonate
CAS:Prodotto controllato<p>Stability Moisture sensitive<br>Applications Chloromethyl Isopropyl Carbonate is an antiviral agent and a Tenofovir (T018500) intermediate. Tenofovir is an acyclic phosphonate nucleotide analogue and reverse transcriptase inhibitor used as an anti-HIV agent.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Mackman, R., et al.: Bioorg. Med. Chem., 15, 5519 (2007), Baudy, R., et al.: J. Med. Chem., 52, 771 (2009),<br></p>Formula:C5H9ClO3Colore e forma:NeatPeso molecolare:152.58Zolmitriptan
CAS:Prodotto controllato<p>Applications Zolmitriptan is a serotonin 5HTID-receptor agonist and used to treat migraine (1,2,3).<br>References (1) Glen, R.C., et al.: J. Med. Chem., 38, 3566 (1995)(2) Seaber, E., et al.: Brit. J. Clin. Pharmacol., 41, 141 (1996)(3) Tepper, S.J., et al.: Curr. Med. Res. Opin., 15, 254 (1999)<br></p>Formula:C16H21N3O2Colore e forma:NeatPeso molecolare:287.361-(1,3-Dioxolan-2-ylmethyl)-N-methyl-4-(methylamino)-1H-imidazole-5-carboxamide
CAS:Prodotto controllatoFormula:C10H16N4O3Colore e forma:NeatPeso molecolare:240.26Sumatriptan Succinate
CAS:Prodotto controllato<p>Applications Sumatriptan Succinate is a selective 5-HT1B/1D-receptor agonist with anticonvulsant properties (1,2). Sumatriptan Succinate is used for migraine relief (2).<br>References (1) Razzaque, Z., et al.: Br J Clin Pharmacol. 47, 75 (1999) (2) Cady, R. K., et al.: J Headache Pain. 18, 17 (2017)<br></p>Formula:C14H21N3O2S·C4H6O4Colore e forma:White To Off-WhitePeso molecolare:413.492-Hydrazino Adenosine
CAS:Prodotto controllato<p>Stability Moisture Sensitive<br>Applications A useful synthetic intermediate for making potent and selective coronary vasodilators.<br>References Niiya, K., et al.: J. Med. Chem., 35, 4557 (1992)<br></p>Formula:C10H15N7O4Colore e forma:NeatPeso molecolare:297.273-(2-CHLOROPYRIMIDIN-4-YL)-1-(CYCLOPROPYLSULFONYL)-1H-INDOLE
Purezza:95.0%Peso molecolare:333.7900085449219Fenclorim
CAS:Prodotto controllato<p>Applications Herbicide safener.<br>References Lee, H., et al.: Eur. J. Med. Chem., 40, 862 (2005), Wright, S., et al.: Bioorg. Med. Chem. Lett., 17, 5638 (2007), Brazier-Hicks, M., et al.: J. Biol. Chem., 283, 21102 (2008), Vinggaard, A., et al.: Chem. Res. Toxicol., 21, 813 (2008),<br></p>Formula:C10H6Cl2N2Colore e forma:BeigePeso molecolare:225.076-Methylpurine
CAS:Prodotto controllato<p>Applications 6-Methylpurine (cas# 2004-03-7) is a compound useful in organic synthesis.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>Formula:C6H6N4Colore e forma:NeatPeso molecolare:134.14Ref: 10-F530152
1gPrezzo su richiesta100mgPrezzo su richiesta250mgPrezzo su richiesta500mgPrezzo su richiesta1-Methyluric Acid-d3
CAS:Prodotto controllato<p>Applications A labelled metabolite of Theophylline.<br>References Chen, Y., et al.: Clin. Exper. Pharmacol. Physiol., 36, 828 (2009), Yu, C., et al.: J. Bacteriol., 191, 4624 (2009), Jetter, A., et al.: Eur. J. Clin. Pharmacol., 65, 411 (2009),<br></p>Formula:C62H3H3N4O3Colore e forma:NeatPeso molecolare:185.167-Methyl Xanthine
CAS:Prodotto controllato<p>Applications Metabolite of Theophylline and Caffeine.<br>References Yu, Ch. et al.: J. Bacteriol. 191, 4624 (2009); Geraets, L. et al.: Biochem. Pharmacol. 72, 902 (2006).<br></p>Formula:C6H6N4O2Colore e forma:NeatPeso molecolare:166.14D-Neopterin-13C5
CAS:<p>Applications Labelled precursor in the biosynthesis of Biopterin. First isolated from the pupae of bees.<br>References Kobashi, I., et al.: Agric. Biol. Chem., 35, 47 (1971), Fukushima, S., et al.: J. Biol. Chem., 247, 4549 (1972),<br></p>Formula:C413C5H11N5O4Colore e forma:Light Beige To BrownPeso molecolare:258.18Tenofovir Alafenamide
CAS:Prodotto controllato<p>Stability Hygroscopic<br>Applications Tenofovir Alafenamide is a prodrug of Tenofovir (T018500), which is a reverse transcriptase inhibitor used to treat HIV and Hepatitis B. Antiviral.<br>References Shaw, J.-P., et al.: Pharm. Res., 14, 1824 (1997), Wyles, D., et al.: Clin Infect. Dis., 40, 174 (2005), Peng, J., et al.: J. Clin. Pharmacol., 46, 265 (2006), Seminari, E., et al.: J. Antimicrob. Chemother., 60, 831 (2007),<br></p>Formula:C21H29N6O5PColore e forma:NeatPeso molecolare:476.47Sulbutiamine
CAS:Prodotto controllato<p>Applications Sulbutiamine (isobutyryl thiamine disulfide) is a lipophilic derivative of thiamine used for the treatment of asthenia and other related pathological conditions. Sulbutiamine is available over-the-counter in several countries as a component of nutritional supplements.<br>References Micheau, J., et al.: Pharmacol. Biochem. Behav., 23, 195 (1985), Bettendorff, L., et al.: Biochem. Pharmacol., 40, 2557 (1990), van Reeth, O., et al.: Drugs Today, 35, 187 (1999),<br></p>Formula:C32H46N8O6S2Colore e forma:Off WhitePeso molecolare:702.894-[2’-(7’’-Deazaguanine)ethyl]benzoic Acid N-Hydroxysuccinimide Ester
CAS:Prodotto controllato<p>Applications Intermediate in the preparation of Pemetrexed.<br></p>Formula:C19H17N5O5Colore e forma:WhitePeso molecolare:395.372-[3-Carboxy-4-(2-methylpropoxy)phenyl]-4-methyl-5-thiazolecarboxylic Acid
CAS:Prodotto controllato<p>Applications 2-[3-Carboxy-4-(2-methylpropoxy)phenyl]-4-methyl-5-thiazolecarboxylic Acid is an impurity of Febuxostat (F229000), an xanthine oxidase/ xanthine dehydrogenase inhibitor used for the treatment of hyperuricemia and chronic gout.<br>References Kadivar, M.H.,e t al.: J. Pharm. Biomed. Anal., 56, 749 (2011);<br></p>Formula:C16H17NO5SColore e forma:White SolidPeso molecolare:335.37(2R,3R,4R,5R)-5-(4-benzamido-2-oxopyrimidin-1(2H)-yl)-2-((benzoyloxy)methyl)-4-fluoro-4-methyltetrahydrofuran-3-yl benzoate
CAS:Purezza:97%Peso molecolare:571.5609741210938Ref: 10-F790039
1gPrezzo su richiesta5gPrezzo su richiesta10gPrezzo su richiesta25gPrezzo su richiesta100gPrezzo su richiesta250mgPrezzo su richiestaOndansetron
CAS:Prodotto controllato<p>Applications Ondansetron is a specific serotonin (5-HT3) receptor antagonist. Antiemetic.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Kris, M.G., et al.: J. Clin. Oncol., 6, 659 (1988); Faris, P..L., et al.: Lances, 355, 792 (2000)<br></p>Formula:C18H19N3OColore e forma:White To Light BeigePeso molecolare:293.36N10-Methyl Pteroic Acid
CAS:<p>Impurity Methotrexate EP Impurity D<br>Applications N10-Methyl Pteroic Acid (Methotrexate EP Impurity D) is a Methotrexate (M260675) impurity D.<br>References Cramer, S., et al.: Cancer Res. 1984, 44, 1843 (1984), Hendel, J., et al.: Eur. J. Clin. Pharmacol., 26, 103 (1984),<br></p>Formula:C15H14N6O3Colore e forma:Orange To Dark RedPeso molecolare:326.31N-Nitroso Desmethyl Sumatriptan
Prodotto controllatoFormula:C13H18N4O3SColore e forma:Orange To BrownPeso molecolare:310.372Nicotinic Acid-13C6
CAS:<p>Applications Nicotinic Acid-13C6 is labelled Nicotinic acid. It is a precursor of the coenzymes NAD and NADP. Widely distributed in nature; appreciable amounts are found in liver , fish, yeast and cereal grains. Dietary deficiency is associated with pellagra. The term “niacin” has also been applied to nicotinamide or to other derivatives exhibiting the biological activity of nicotinic acid. Vitamin (enzyme cofactor).<br>References Darby, W.J., et al.: Nutr. Rev., 33, 289 (1975), Black, A., et al.: Eur. J. Clin. Nutr., 54, 395 (2000), Cole, T., et al.: Br. Med. J., 320, 1240 (2000), Forshee, R., et al.: J. Nutr., 134, 2733 (2004),<br></p>Formula:C6H5NO2Colore e forma:NeatPeso molecolare:129.072,2,2-Trichloro-acetic Acid
CAS:<p>Applications 2,2,2-Trichloro-acetic Acid is an acetic acid analogue used for the precipitation of macromolecules including proteins, DNA and RNA as well as for cosmetic treatments.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Wiley D. et al.: Clin. Infect. Dis., 35m S210 (2002);<br></p>Formula:C2HCl3O2Colore e forma:Colourless To Off-WhitePeso molecolare:163.391-Methyl-4-[5-(2-methylsulfamoylethyl)-1H-indol-3-yl]pyridinium Chloride
Prodotto controllato<p>Impurity Naratriptan pyridinium Impurity<br>Stability Hygroscopic<br>Applications Naratriptan (N378730) impurity.<br></p>Formula:C17H20ClN3O2SColore e forma:NeatPeso molecolare:365.88Dihydro Caffeic Acid 3-O-β-D-Glucuronide Diammonium Salt
CAS:Prodotto controllato<p>Stability Hygroscopic<br>Applications Dihydro Caffeic Acid 3-O-β-D-Glucuronide is a glucuronide metabolite of Caffeic Acid (C080000).<br>References Clifford, M., et al.: J .Agric. Food Chem., 53, 3821 (2005), Lafay, S., et al.: J. Nutr., 136, 1192 (2006), Poquet, L., et al.: Drug Metab. Dispos., 36, 190 (2008)<br></p>Formula:C15H18O10•2NH3Colore e forma:NeatPeso molecolare:358.3021703MTIC
CAS:<p>Applications A metabolite of Temozolomide, an antineoplastic.<br></p>Formula:C5H8N6OColore e forma:Off-WhitePeso molecolare:168.16Febuxostat n-Butyl Isomer
CAS:Prodotto controllato<p>Applications Febuxostat n-butyl Isomer is an impurity of Febuxostat (F229000) which is a xanthine oxidase/xanthine dehydrogenase inhibitor.<br>References Osada, Y., et al.: Eur. J. Pharmacol., 241, 183 (1993); Okamoto, K., et al.: J. Biol. Chem., 278, 1848 (2003); Mayer, M.D., et al.: Am. J. Therap., 12, 22 (2005); Tomlinson, B., et al.: Curr. Opin. Invest. Drugs, 6, 1168 (2005)<br></p>Formula:C16H16N2O3SColore e forma:NeatPeso molecolare:316.374-Amino-1,3-dimethyl-5-nitrosouracil x-H2O
CAS:Prodotto controllato<p>Applications 4-Amino-1,3-dimethyl-5-nitrosouracil is a useful building block for organic synthesis.<br></p>Formula:C6H8N4O3Colore e forma:NeatPeso molecolare:184.15Desisobutyl Febuxostat
CAS:Prodotto controllatoFormula:C12H8N2O3SColore e forma:Light Yellow SolidPeso molecolare:260.27Methotrexate (1 mg/mL in Methanol with 0.1N NaOH)
CAS:Formula:C20H22N8O5Colore e forma:Single SolutionPeso molecolare:454.444-(3-fluorophenyl)-6-(furan-2-yl)pyrimidin-2-amine
CAS:Purezza:95.0%Peso molecolare:255.25199890136726-hydroxy-5-nitro-1,2,3,4-tetrahydropyrimidine-2,4-dione
Purezza:98%Peso molecolare:173.08399963378906Ref: 10-F788415
1gPrezzo su richiesta2gPrezzo su richiesta5gPrezzo su richiesta10gPrezzo su richiesta25gPrezzo su richiesta100mgPrezzo su richiesta250mgPrezzo su richiesta500mgPrezzo su richiesta1-(5-ETHYLPYRIMIDIN-2-YL)PIPERIDIN-4-YL METHANESULFONATE
CAS:Purezza:90.0%Peso molecolare:285.3599853515625Ref: 10-F530739
1gPrezzo su richiesta2gPrezzo su richiesta5gPrezzo su richiesta100mgPrezzo su richiesta250mgPrezzo su richiesta500mgPrezzo su richiestaEthyl 2-(2-(dimethylamino)pyrimidin-4-yl)-1H-indole-5-carboxylate
CAS:Purezza:95.0%Peso molecolare:310.35699462890625Tert-butyl 4-(5-hydroxypyrimidin-2-yl)piperazine-1-carboxylate
CAS:Purezza:98%Peso molecolare:280.3280029296875Ref: 10-F768179
1gPrezzo su richiesta2gPrezzo su richiesta5gPrezzo su richiesta100mgPrezzo su richiesta250mgPrezzo su richiesta500mgPrezzo su richiesta4-[6-(2-Methoxy-phenyl)-pyridin-3-yl]-pyrimidin-2-ylamine
Purezza:95.0%Peso molecolare:278.31500244140625
![2-[[3-[2-(Dimethylamino)ethyl]-1H-indol-5-yl]methyl] Sumatriptan (>90%)](/_next/image/?url=https%3A%2Fstatic.cymitquimica.com%2Fproducts%2FTR%2Fthumb-webp%2FD446670.webp&w=3840&q=75)
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