Derivati delle Purine e Pirimidine
Le purine hanno una struttura biciclica, composta da un anello a sei membri fuso con un anello a cinque membri, entrambi contenenti atomi di azoto in posizioni chiave. I derivati delle purine, come l’adenina e la guanina, sono essenziali per la formazione del DNA e dell’RNA. Questi composti trovano applicazione terapeutica nei trattamenti contro il cancro e le malattie virali, inibendo la replicazione cellulare. Le pirimidine, invece, hanno una struttura monociclica a sei membri con due atomi di azoto. I loro derivati, come la citosina, la timina e l’uracile, sono anch’essi componenti fondamentali del DNA e dell’RNA e vengono utilizzati in chemioterapia e nei trattamenti antivirali.
Presso CymitQuimica, offriamo derivati delle purine e pirimidine per la ricerca in biologia molecolare, genomica e sviluppo di terapie innovative.
Trovati 8902 prodotti di "Derivati delle Purine e Pirimidine"
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1gPrezzo su richiesta2.5gPrezzo su richiesta250mgPrezzo su richiesta500mgPrezzo su richiesta1,2,3,9-Tetrahydro-4H-carbazol-4-one
CAS:Prodotto controllato<p>Applications A carbazole derivative with antimycobacterial activity.<br>References Romeo, G., et al.: Bioorg. Med. Chem., 14, 5211 (2006),<br></p>Formula:C12H11NOColore e forma:BeigePeso molecolare:185.22Regadenoson
CAS:Prodotto controllato<p>Applications Regadenoson is a selective and potent A2A adenosine receptor agonist (1). The adenosine A2A receptor is a G-protein-coupled receptor and a key therapeutic target for oncologic, inflammatory, Parkinson's and cardiovascular diseases (2). In rodent studies, it has been shown that co-administration of Regadenoson with Temozolomide (T017775) can increase Temozolomide concentration in the brain (3).<br>References (1) Gao, Z., et al.: J Pharmacol Exp Ther. 298, 209 (2001) (2) Yuan, G., et al.: Expert Opin Drug Discov. 10, 63 (2015) (3) Jackson, S., et al.: J Neurooncol. 126, 433 (2016)<br></p>Formula:C15H18N8O5Colore e forma:Off WhitePeso molecolare:390.353,5-Dimethyl-1-adamantanol
CAS:Prodotto controllato<p>Impurity Memantine USP Related Compound B (3,5-Dimethyladamantane-1-ol)<br>Applications 3,5-Dimethyl-1-adamantanol is an impurity of Memantine (M218000). Memantine impurity B. Memantine USP Related Compound B (3,5-Dimethyladamantane-1-ol).<br>References England, P., et al.: Biochemistry, 43, 11623 (2004), Schousboe, A., et al.: Eur. J. Pharmacol., 500, 281 (2004), Horvat, S., et al.: J. Med. Chem., 49, 3136 (2006),<br></p>Formula:C12H20OColore e forma:WhitePeso molecolare:180.293-Amino-4-carbamoylpyrazole Hemisulfate
CAS:Prodotto controllato<p>Impurity Allopurinol EP Impurity A / Allopurinol USP Related Compound A<br>Stability Hygroscopic<br>Applications 3-Amino-4-carbamoylpyrazole Hemisulfate (Allopurinol EP Impurity A) is an impurity of Allopurinol (A547300), a pyrazole derivative that has been shown to induce neoplasm immunogenicity.<br>References Nicolin, A. et al.: Cancer, Chemother. Rep., 57, 3 (1973); Bonmassar, E. et al.: Cancer Res., 35, 1957 (1975);<br></p>Formula:C4H6N4O·H2O4SColore e forma:White To Light BrownPeso molecolare:350.311,3,5-Trimethyladamantane
CAS:Prodotto controllato<p>Applications An alkyladamantane derivative that are biotransformed via strains of Pseudomonas. It is used to study alkyladamantane adsorption on graphitized thermal carbon black.<br>References Yashkin, S.N. et al.: Rus. Che,. Bull., 57, 2472 (2008); Slepen’kin, A. et al.: Nefeckhim., 33, 406 (1993);<br></p>Formula:C13H22Colore e forma:NeatPeso molecolare:178.31Methotrexate-d3 Hexaglutamate Trifluoroacetic Acid Salt
CAS:Prodotto controllato<p>Applications Methotrexate-d3 Hexaglutamate is the isotope labelled analog of Methotrexate Hexaglutamate (M260745); a metabolite of Methotrexate (M260675) which is a folic acid antagonist, antineoplastic, and antirheumatic.<br>References Freeman, M.V., J. Pharmacol. Exp. Ther., 122, 154 (1958); Weinblass, M.E., et al.: N. Engl. J. Med., 312, 818 (1985)<br></p>Formula:C45H54D3N13O20•x(C2HF3O2)Colore e forma:NeatPeso molecolare:1103.03114026-Amino-1,3-dipropyl-5-nitrosouracil
CAS:Prodotto controllato<p>Stability Stable at RT<br>Applications An intermediate used for the sythesis of xanthine derivatives.<br>References Daly, J.W., et al.: J. Med. Chem., 28, 487 (1985), Erickson, R.H., et al.: J. Med. Chem., 34, 3405 (1991),<br></p>Formula:C10H16N4O3Colore e forma:NeatPeso molecolare:240.26Febuxostat
CAS:<p>Applications Xanthine oxidase/xanthine dehydrogenase inhibitor. Used for treatment of hyperuricemia and chronic gout. 40-120 mg/day febuxostat was proven effective in lowering serum urate levels when administered to manage hyperuricemia in patients with gout.<br>References Osada, Y., et al.: Eur. J. Pharmacol., 241, 183 (1993), Okamoto, K., et al.: J. Biol. Chem., 278, 1848 (2003), Mayer, M.D., et al.: Am. J. Therap., 12, 22 (2005), Tomlinson, B., et al.: Curr. Opin. Invest. Drugs, 6, 1168 (2005),<br></p>Formula:C16H16N2O3SColore e forma:White To Off-WhitePeso molecolare:316.371-(1,3-Dioxolan-2-ylmethyl)-N-methyl-4-(methylamino)-1H-imidazole-5-carboxamide
CAS:Prodotto controllatoFormula:C10H16N4O3Colore e forma:NeatPeso molecolare:240.26Tenofovir Monoisoproxil Dimer Ammonium Sodium Salt (>85%)
Prodotto controllato<p>Stability Light Sensitive, Temperature Sensitive, Very Hygroscopic<br>Applications Tenofovir Monoisoproxil Dimer Ammonium Sodium Salt is an impurity in the synthesis of Tenofovir disoproxil (T018505),an acyclic phosphonate nucleotide analogue; reverse transcriptase inhibitor.<br>References Peng, J., et al.: J. Clin. Pharmacol., 46, 265 (2006), Seminari, E., et al.: J. Antimicrob. Chemother., 60, 831 (2007),<br></p>Formula:C29H42N10O14P2•x(Na)•x(NH3)Purezza:>85%Colore e forma:NeatPeso molecolare:816.65 + x(22.99) + x(17.03)2,4-Bis(dimethylamino)pyrimidine-6-carboxylic acid, hydrate
CAS:Formula:C9H16N4O3Purezza:95.0%Peso molecolare:228.252β-Nicotinamide Mononucleotide
CAS:<p>Stability Very Hygroscopic<br>Applications A product of the extracellular Nicotinamide phosphoribosyltransferase (eNAMPT) reaction and a key NAD+ intermediate. It ameliorates glucose intolerance by restoring NAD+ levels in HFD-induced T2D mice. It also enhances hepatic insulin sensitivity and restores gene expression related to oxidative stress, inflammatory response, and circadian rhythm, partly through SIRT1 activation.<br>References Yoshino, J. et al.: Cell Metab., 14, 528 (2011); Caton, P.W. et al.: Diabetologia, 54, 3083 (2011); Formentini, L. et al.: BIochem. Pharmacol., 77, 1612 (2009);<br></p>Formula:C11H15N2O8PColore e forma:WhitePeso molecolare:334.221-Methyl-nicotinamide Iodide
CAS:Prodotto controllato<p>Applications A nicotinic acid derivative which shows a dopaminergic neurotoxicity.<br>References Rollema, H., et al.: J. Med. Chem., 33, 2221 (1990),<br></p>Formula:C7H9IN2OColore e forma:NeatPeso molecolare:264.061-(Naphthalen-2-yl)-3-(2-oxo-2-(pyrrolidin-1-yl)ethyl)urea
CAS:Purezza:98%Peso molecolare:297.3580017089844Chloromethyl Isopropyl Carbonate
CAS:Prodotto controllato<p>Stability Moisture sensitive<br>Applications Chloromethyl Isopropyl Carbonate is an antiviral agent and a Tenofovir (T018500) intermediate. Tenofovir is an acyclic phosphonate nucleotide analogue and reverse transcriptase inhibitor used as an anti-HIV agent.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Mackman, R., et al.: Bioorg. Med. Chem., 15, 5519 (2007), Baudy, R., et al.: J. Med. Chem., 52, 771 (2009),<br></p>Formula:C5H9ClO3Colore e forma:NeatPeso molecolare:152.584-Hydroxyphenylpyruvic Acid
CAS:Formula:C9H8O4Colore e forma:Light Yellow To OrangePeso molecolare:180.16Xanthine-13C15N2
CAS:Prodotto controllato<p>Applications Isotope labelled analog of Xanthine (X499950), a substance that can be found in animal organs, yeast, patatoes, coffee beans, tea. Xanthine can be used to relax and widen certain breathing passages of the lungs. It is also found that a large number of derivatives that exhibits adenoside receptor antagonist properties.<br>References Mueller, C. et. al: Handbook Exp. Pharmacol. 200,151(2011)<br></p>Formula:C413CH4N215N2O2Colore e forma:Light Yellow To Light BeigePeso molecolare:155.09Methotrexate-d3 Diglutamate Trifluoroacetate
CAS:Prodotto controllato<p>Applications Methotrexate-d3 Diglutamate is the isotope labelled analog of Methotrexate Diglutamate (M260720); a metabolite of Methotrexate (M260675) which is a folic acid antagonist, antineoplastic, and antirheumatic.<br>References Freeman, M.V., J. Pharmacol. Exp. Ther., 122, 154 (1958); Weinblass, M.E., et al.: N. Engl. J. Med., 312, 818 (1985)<br></p>Formula:C25H26D3N9O8•x(C2HF3O2)•xH2SO4Colore e forma:NeatPeso molecolare:586.58114029812-[[3-[2-(Dimethylamino)ethyl]-1H-indol-5-yl]methyl] Sumatriptan (>90%)
CAS:Prodotto controllato<p>Impurity Sumatriptan EP Impurity A<br>Stability Light Sensitive<br>Applications 2-[[3-[2-(dimethylamino)ethyl]-1H-indol-5-yl]methyl] Sumatriptan Succinate (Sumatriptan EP Impurity A) is an impurity of Sumatriptan (S810000), a serotonin 5HT-1-receptor agonist.<br>References Skwierawska, A.. et al.: Poish. J. Chem., 77, 329 (2003);<br></p>Formula:C27H37N5O2SColore e forma:Off White SolidPeso molecolare:495.685-Methyl-3-methylene-2-hexanone
CAS:Prodotto controllato<p>Applications 5-Methyl-3-methylene-2-hexanone is an impurity of Tetrabenazine (T284000), an antipsychotic.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Brossi, A., et al.: Helv. Chim. Acta, 43, 583 (1960);<br></p>Formula:C8H14OColore e forma:NeatPeso molecolare:126.204-(5-methylfuran-2-yl)-6-(3,4,5-trimethoxyphenyl)pyrimidin-2-amine
CAS:Purezza:95.0%Peso molecolare:341.367004394531253-Methyluric Acid
CAS:<p>Applications 3-Methyluric Acid is a methylated derivative of uric acid that inhibits peroxynitrite-mediated oxidation, which has potential therapeutic application in the treatment of multiple sclerosis. 3-Methyluric Acid is also a known metabolite of Caffeine (C080100).<br>References Kean, R.B. et al.: J. Immunol., 165, 6511 (2000); Caubet, M.-S. et al.: J. Pharm. Biomed. Anal., 27, 261 (2002);<br></p>Formula:C6H6N4O3Colore e forma:Light YellowPeso molecolare:182.145-[(1S)-1-(2-Chlorophenyl)-2-methoxy-2-oxoethyl]-6,7-dihydro-Thieno[3,2-c]pyridinium Bromide
CAS:Prodotto controllatoFormula:C16H15BrClNO2SColore e forma:NeatPeso molecolare:400.72Paraxanthine
CAS:<p>Stability Store tightly sealed at RT<br>Applications Paraxanthine is an adenosine receptor ligand and a major metabolite of caffeine.This compound is a contaminant of emerging concern (CECs).<br>References Proc. Natl. Acad. Sci. USA 78, 3260 (1981); Cell Mol. Neurobiol., 3, 69 (1983); Eur. J. Pharmacol., 179, 295 (1990)<br></p>Formula:C7H8N4O2Colore e forma:White To Light YellowPeso molecolare:180.16Ref: 10-F531105
1gPrezzo su richiesta2gPrezzo su richiesta5gPrezzo su richiesta100mgPrezzo su richiesta250mgPrezzo su richiesta500mgPrezzo su richiesta2-Chloro-N-piperidin-4-ylpyrimidin-4-amine hydrochloride
CAS:Purezza:97.0%Peso molecolare:249.13999938964844Tenofovir Disoproxil Dimer
CAS:Prodotto controllato<p>Stability Very Hygroscopic and Temperature Sensitive<br>Applications Tenofovir Disoproxil impurity.<br>References Cheng, G., et al.: Chem. Res. Toxicol., 16, 145 (2003),<br></p>Formula:C39H60N10O20P2Colore e forma:White SolidPeso molecolare:1050.904,6-Dihydroxypyrazolo[3,4-d]pyrimidine-13C,15N2
CAS:Prodotto controllato<p>Applications A labelled metabolite of Allopurinol.<br>References Marro, P., et al.: Brain Res., 650, 9 (1994), Abramov, A., et al.: J. Neurosci., 27, 1129 (2007), Day, R., et al.: Clin. Pharmacokinet., 46, 623 (2007),<br></p>Formula:CC4H415N2N2O2Colore e forma:White To BeigePeso molecolare:155.09(E/Z)-3-[(2-Cyano-3-ethoxy-3-oxo-1-propenyl)amino]-1H-Pyrazole-4-carboxylic Acid Ethyl Ester
CAS:<p>Applications Impurity of Allopurinol (A547300), an xanthine oxidase inhibitor used in treatment of hyperuricemia and chronic gout. Antiurolithic.<br>References Benezra, S.A., et al.: Anal. Profiles Drug Subs., 7, 1, (1978), Dalbeth, N., et al.: Rheumatology, 44, 1090 (2005), Dinarello, C., et al.: J. Exp. Med., 201, 1355 (2005),<br></p>Formula:C12H14N4O4Colore e forma:NeatPeso molecolare:278.274-Chloro-2,6-diphenylpyrimidine
CAS:Purezza:95.0%Colore e forma:SolidPeso molecolare:266.7300109863281(6-Methoxy-2-methylsulfanyl-pyrimidin-4-yl)-piperidin-4-yl-amine hydrochloride
CAS:Purezza:95.0%Peso molecolare:290.809997558593754-(3-fluorophenyl)-6-(thiophen-2-yl)pyrimidin-2-amine
CAS:Purezza:95.0%Peso molecolare:271.309997558593755-Cyclopropyl-2-thioxo-2,3-dihydro-1H-pyrimidin-4-one
CAS:Formula:C7H8N2OSPurezza:95.0%Colore e forma:SolidPeso molecolare:168.21N-Methyl Pemetrexed
CAS:Prodotto controllato<p>Impurity Pemetrexed EP Impurity A<br>Applications N-Methyl Pemetrexed (Pemetrexed EP Impurity A) is an impurity of Pemetrexed (P219500), an multitargeted antifolate that inhibits thymidylate synthase as well as other folate dependent enzymes.<br>References Kjell, D.P., et al.: Org. Proc. Res. Develop., 9, 738 (2005);<br></p>Formula:C21H23N5O6Colore e forma:NeatPeso molecolare:441.44DAMPA-d3
CAS:Prodotto controllato<p>Applications Labelled Methotrexate (M260675) analog. DAMPA is an antitumor agent.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Martinelli, J.E., et al.: J. Med. Chem., 22, 869 (1979);<br></p>Formula:C152H3H12N7O2Colore e forma:Dark OrangePeso molecolare:328.34Methyl 2-[3-Cyano-4-(2-methylpropoxy)phenyl]-4-methylthiazole-5-carboxylate
CAS:Prodotto controllatoFormula:C17H18N2O3SColore e forma:NeatPeso molecolare:330.4Methotrexate Diglutamate Trifluoroacetate
CAS:Prodotto controllato<p>Stability Hygroscopic<br>Applications Methotrexate Diglutamate is a metabolite of Methotrexate (M260675); a folic acid antagonist, antineoplastic, and antirheumatic.<br>References Freeman, M.V., J. Pharmacol. Exp. Ther., 122, 154 (1958); Weinblass, M.E., et al.: N. Engl. J. Med., 312, 818 (1985)<br></p>Formula:C25H29N9O8xC2HF3O2Colore e forma:NeatPeso molecolare:583.552-Isopropyl-pyrimidine-5-carboxylic acid
CAS:Formula:C8H10N2O2Purezza:95.0%Colore e forma:SolidPeso molecolare:166.184-(2H-1,3-benzodioxol-5-yl)-6-(thiophen-2-yl)pyrimidin-2-amine
CAS:Purezza:95.0%Peso molecolare:297.3299865722656LY 368962
CAS:Prodotto controllato<p>Applications LY 368962 is a metabolite of the antifolate Pemetrexed (P219500).<br>References Woodland, J.M. et al.: Drug Metab. Dispos., 25, 693 (1997);<br></p>Formula:C19H21N5O7Colore e forma:NeatPeso molecolare:431.402-CHLOROPYRIMIDINE-4-CARBALDEHYDE
CAS:Formula:C5H3ClN2OPurezza:95.0%Colore e forma:Liquid, No data available.Peso molecolare:142.54
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