Derivati delle Benzodiazepine
Le benzodiazepine sono composti organici con un nucleo biciclico fuso di benzodiazepina, ampiamente utilizzati nello sviluppo di farmaci con proprietà ansiolitiche, sedative, anticonvulsivanti e miorilassanti. I loro derivati includono strutture modificate che ne migliorano la selettività e il profilo farmacocinetico, consentendo la creazione di nuove molecole con applicazioni terapeutiche avanzate. Questi composti sono impiegati nella formulazione di API per il trattamento dei disturbi del sonno, dell’ansia, dell’epilessia e degli spasmi muscolari. Inoltre, i derivati delle benzodiazepine sono fondamentali nella ricerca di nuovi agenti psicotropi e nell’ottimizzazione dei trattamenti neurologici.
Presso CymitQuimica, offriamo derivati delle benzodiazepine di alta purezza per applicazioni in sintesi chimica, sviluppo farmaceutico e neuroscienze.
Trovati 333 prodotti di "Derivati delle Benzodiazepine"
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5-Chloro-2-(3-methyl-4H-1,2,4-triazol-4-yl)benzophenone
CAS:<p>Applications An impurity of Alprazolam (A575650).<br>References Cho, M., et al.: J. Med. Chem., 29, 1346 (1986), Hall, M., et al.: J. Anal. Toxicol., 19, 511 (1995), Nudelman, N., et al.: J. Pharm. Sci., 84, 998 (1995), Yuan, R., et al.: J. Clin. Pharmacol., 39, 1109 (1999),<br></p>Formula:C16H12ClN3OColore e forma:NeatPeso molecolare:297.74Clonazepam-13C2 ,15N
CAS:Prodotto controllato<p>Applications Clonazepam-13C2 ,15N, is the labeled analogue of Clonazepam (C587080), an antiepileptic agent with anxiolytic and antimanic properties.<br>References Blum, et al.: Arzneim.-Forsch., 23, 377 (1973), Winslow, W.C., et al.: Anal. Profiles Drug Subs., 6, 61 (1977)<br></p>Formula:C1313C2H10ClN215NO3Colore e forma:NeatPeso molecolare:318.69Nor-Flunitrazepam
CAS:Prodotto controllato<p>Applications A metabolite of Flunitrazepam (F500700).<br>References Asai, H., et al.: J. Pharmacol. Exp. Ther., 277, 1004 (1996), Kilicarslan, T., et al.: Drug Metab. Dispos., 29, 460 (2001), Tanaka, E., et al.: J. Toxicol. Clin. Toxicol., 40, 69 (2002),<br></p>Formula:C15H10FN3O3Colore e forma:YellowPeso molecolare:299.262-Amino-5-chlorobenzophenone
CAS:Prodotto controllato<p>Applications A metabolite of Diazepam; but has a much weaker anticonvulsant effect.<br>References Hara, T., et al.: J. Med. Chem., 21, 263 (1978),<br></p>Formula:C13H10ClNOColore e forma:YellowPeso molecolare:231.68N-Desmethyl Clobazam-13C6
CAS:Prodotto controllato<p>Applications N-Desmethyl Clobazam-13C6 is an isotope labelled metabolite of Clobazam (C582500), a benzodiazepine psychotherapeutic agent that has proven efficacy against multiple seizure types.<br>References Gastaut, H., et al.: Epilepsia, 20, 437 (1979); Guberman, A., et al.: Can J. Neurol. Sci., 17, 311 (1990); Munn, R., et al.: Pediatr. Neurol. 9, 465 (1993)<br></p>Formula:C913C6H11ClN2O2Colore e forma:Off-WhitePeso molecolare:292.6695-Chloro-2-(3-chloromethyl-4H-1,2,4-triazol-4-yl)-benzophenone
CAS:Prodotto controllato<p>Applications 5-Chloro-2-(3-chloromethyl-4H-1,2,4-triazol-4-yl)-benzophenone is an impurity in the synthesis of Estazolam (E668380), a benzodiazepine derivative possessing anxiolytic, anticonvulsant, and muscle relaxant properties. It is commonly prescribed to treat short-term insomnia.<br>References Barroso, M., et al.: Anal. Bioanal. Chem., 396, 3059 (2010), Rodgers, A., et al.: Chem. Res., Toxicol., 23, 724 (2010), Dresen, S., et al.: Anal. Bioanal. Chem., 396, 2425 (2010),<br></p>Formula:C16H11Cl2N3OColore e forma:NeatPeso molecolare:332.187-Acetamido Nitrazepam
CAS:Prodotto controllatoFormula:C17H15N3O2Colore e forma:NeatPeso molecolare:293.323-Amino-6-chloro-4-phenylcarbostyril
CAS:<p>Applications Intermediate in the preparation of Alprazolam impurities.<br>References Hanawa, T., et al.: Drug Dev. Ind. Pharm., 26, 1199 (2000), Cheng, P., et al.: Bioorg. Med. Chem. Lett., 18, 3787 (2008),<br></p>Formula:C15H11ClN2OColore e forma:NeatPeso molecolare:270.712-Bromo-N-[2-(2-chlorobenzoyl)-4-nitrophenyl]acetamide(Clonazepam Impurity)
CAS:Prodotto controllato<p>Applications An impurity from the synthesis of clonazepam (C587080)<br></p>Formula:C15H10BrClN2O4Colore e forma:Light YellowPeso molecolare:397.612-[3-(Hydroxymethyl)-5-methyl-4-triazolyl]-5-chlorobenzophenone
CAS:<p>Applications An impurity of Alprazolam (A575650).<br>References Nudelman, N., et al.: J. Pharm. Sci., 91, 1274 (2002), Marin, A., et al.: Anal. Chem., 77, 471 (2005),<br></p>Formula:C17H14ClN3O2Colore e forma:Off White SolidPeso molecolare:327.763-Hydroxy Bromazepam-d4
CAS:Prodotto controllato<p>Applications Major metabolite of labelled Bromazepam (B678502)<br>References Musshoff, F., et al.: Clin. Chem. Lab. Med., 36, 803 (1998), El-Haj, B., et al.: J. Anal. Toxicol., 25, 316 (2001), Darzy, K., et al.: Clin. Endocrinol., 70, 287 (2009),<br></p>Formula:C14H6D4BrN3O2Colore e forma:Light YellowPeso molecolare:336.18Clonazepam-d4
CAS:Prodotto controllato<p>Applications Labelled Clonazepam (C587080). Antiepileptic agent with anxiolytic and antimanic properties. Anticonvulsant.This is a controlled substance (depressant).<br>References Blum, et al.: Arzneim.-Forsch., 23, 377 (1973), Winslow, W.C., et al.: Anal. Profiles Drug Subs., 6, 61 (1977)<br></p>Formula:C152H4H6ClN3O3Colore e forma:Yellow To Dark YellowPeso molecolare:319.74N-Desmethyl Clobazam-d5
CAS:Prodotto controllato<p>Applications The major labelled metabolite of Clobazam (C582500). Controlled substance (depressant).<br>References Bardy, A., et al.: Brain Develop., 13, 174 (1991), Patsalos, P., et al.: Epilepsia, 43, 365 (2002), Venisse, N., et al.: J. Anal. Toxicol., 27, 7 (2003),<br></p>Formula:C152H5H6ClN2O2Colore e forma:Off-WhitePeso molecolare:291.74Flumazenil
CAS:Prodotto controllato<p>Applications Flumazenil is an imidazodiazepine which selectively blocks the central effects of classic benzodiazepines. It is used as benzodiazepine antagonist.<br>References Hunkeler, W., et al.: Nature, 290, 514 (1981), Pole, P., et al.: Arch. Pharmacol., 316, 317 (1981), Timm, U., et al.: Arzneim.-Forsch., 33, 358 (1983),<br></p>Formula:C15H14FN3O3Colore e forma:Off WhitePeso molecolare:303.293-Amino-6-nitro-4-phenyl-2(H)-quinolinone
CAS:Prodotto controllatoFormula:C15H11N3O3Colore e forma:OrangePeso molecolare:281.272-(2-Amino-5-bromobenzoyl)pyridine
CAS:<p>Impurity Bromazepam EP impurity A<br>Applications Intermediate in the preparation of Bromazepam.<br>References Panderi, I., et al.: J. Pharm. Biomed. Anal., 17, 327 (1998), El-Haj, B., et al.: J. Anal. Toxicol., 25, 316 (2001), Hansen, S., et al.: J. Pharm. Biomed. Anal., 39, 322 (2005),<br></p>Formula:C12H9BrN2OColore e forma:Light Yellow To YellowPeso molecolare:277.12Alprazolam-d3
CAS:Prodotto controllato<p>Applications Controlled substance (depressant). Anxiolytic.<br>References Sethy, V.H., et al.: Arch. Pharmacol., 301, 157 (1978), Fawcett, J.A., et al.: Pharmacotherapy, 2, 242 (1982),<br></p>Formula:C17H10ClD3N4Colore e forma:NeatPeso molecolare:311.80Clobazam-d5
CAS:Prodotto controllato<p>Applications Labelled Clobazam (C582500). Benzodiazepine psychotherapeutic agent. Clobazam (CLB) has proven efficacy against multiple seizure types. An anxiolytic; anticonvulsant. Controlled substance (depressant).<br>References Gastaut, H., et al.: Epilepsia, 20, 437 (1979), Guberman, A., et al.: Can J. Neurol. Sci., 17, 311 (1990), Munn, R., et al.: Pediatr. Neurol. 9, 465 (1993),<br></p>Formula:C16H8D5ClN2O2Colore e forma:Off White PowderPeso molecolare:305.772-Chloro-N-[2-(2-chlorobenzoyl)-4-nitrophenyl]acetamide
CAS:Formula:C15H10Cl2N2O4Colore e forma:NeatPeso molecolare:353.166-Chloro-2,3-dimethyl-1-phenyl-1H-benzo[d]imidazol-3-ium Chloride
CAS:<p>Applications 6-Chloro-2,3-dimethyl-1-phenyl-1H-benzo[d]imidazol-3-ium Chloride is a degradation product of Clobazam (C582500), a benzodiazepine psychotherapeutic agent that has proven efficacy against multiple seizure types. An anxiolytic; anticonvulsant.<br>References Guberman, A., et al.: Can J. Neurol. Sci., 17, 311 (1990); Munn, R., et al.: Pediatr. Neurol. 9, 465 (1993)<br></p>Formula:C15H14ClN2·ClColore e forma:NeatPeso molecolare:293.191Clonazepam
CAS:Prodotto controllato<p>Applications Antiepileptic agent with anxiolytic and antimanic properties. Anticonvulsant.This is a controlled substance (depressant).<br>References Blum, et al.: Arzneim.-Forsch., 23, 377 (1973), Winslow, W.C., et al.: Anal. Profiles Drug Subs., 6, 61 (1977)<br></p>Formula:C15H10ClN3O3Colore e forma:WhitePeso molecolare:315.71Clobazam-13C6
CAS:Prodotto controllato<p>Applications Clobazam-13C6 is the isotope labelled analog of Clobazam (C582500); a benzodiazepine psychotherapeutic agent. Clobazam (CLB) has proven efficacy against multiple seizure types. An anxiolytic and anticonvulsant. Controlled substance (depressant).<br>References Gastaut, H., et al.: Epilepsia, 20, 437 (1979); Guberman, A., et al.: Can J. Neurol. Sci., 17, 311 (1990); Munn, R., et al.: Pediatr. Neurol. 9, 465 (1993)<br></p>Formula:C6C10H13ClN2O2Colore e forma:Off-WhitePeso molecolare:306.707-Acetamido Clonazepam
CAS:Prodotto controllato<p>Applications Clonazepam (C587080) metabolite.<br>References Huang, W., et al.: J. Anal. Toxicol., 19, 333 (1995), Rittner, M., et al.: J. Anal. Toxicol., 25, 115 (2001),<br></p>Formula:C17H14ClN3O2Colore e forma:NeatPeso molecolare:327.76Deschloro Clobazam
CAS:Prodotto controllato<p>Applications Deschloro Clobazam is a metabolite of Clobazam (C582500), a benzodiazepine psychotherapeutic agent that has proven efficacy against multiple seizure types. An anxiolytic; anticonvulsant.<br>References Guberman, A., et al.: Can J. Neurol. Sci., 17, 311 (1990); Munn, R., et al.: Pediatr. Neurol. 9, 465 (1993)<br></p>Formula:C16H14N2O2Colore e forma:Off WhitePeso molecolare:266.29Ethyl 5-Methyl-6-oxo-5,6-dihydro-4H-benzo[f]imidazo[1,5-a][1,4]diazepine-3-carboxylate
CAS:Prodotto controllato<p>Impurity Flumazenil EP Impurity E<br>Applications Ethyl 5-Methyl-6-oxo-5,6-dihydro-4H-benzo[f]imidazo[1,5-a][1,4]diazepine-3-carboxylate (Flumazenil EP Impurity E) is used in the biological studies and preparation of imidazobenzodiazepines as probes for diazepaminsensitive receptor pharmacophore.<br>References Zhang, P., et al.: J. Med. Chem., 38, 1679 (1995)<br></p>Formula:C15H15N3O3Colore e forma:NeatPeso molecolare:285.302-Bromo-acetamide-2’,5-dichlorobenzophenone
CAS:Prodotto controllato<p>Stability Unstable in Solution, Moisture Sensitive<br>Applications Used in the synthesis of Cloxazolam and its metabolites.<br>References Ji, M. et al.: Zhongguo Yaoke Daxue Xuebao 24, 180 (1993); Ji, M. et al.: Zhongguo Yaoke Daxue Xuebao 25, 69 (1994).<br></p>Formula:C15H10BrCl2NO2Colore e forma:NeatPeso molecolare:387.061-Hydroxy Alprazolam
CAS:Prodotto controllatoFormula:C17H13ClN4OColore e forma:NeatPeso molecolare:324.767-Amino Nitrazepam
CAS:Prodotto controllato<p>Applications A metabolite of Nitrazepam (N490140).<br>References Randall, L.O., et al.: Biochem. Pharmacol., 8, 15 (1961),<br></p>Formula:C15H13N3OColore e forma:Light YellowPeso molecolare:251.286-Methyl Bromazepam
CAS:Prodotto controllatoFormula:C15H12BrN3OColore e forma:NeatPeso molecolare:330.185-Nitro-2-(bromoacetamido)benzophenone
CAS:<p>Applications Nitrazepam derivative.<br>References Hagishita, S., et al.: Bioorg. Med. Chem., 5, 1433 (1997), Amblard, M., et al.: J. Med. Chem., 42, 4185 (1999), Schafferhans, A., et al.: J. Mol. Biol., 307, 407 (2001).<br></p>Formula:C15H11BrN2O4Colore e forma:NeatPeso molecolare:363.163-Hydroxy Bromazepam
CAS:Prodotto controllato<p>Applications Major metabolite of Bromazepam (B678500)<br>References Musshoff, F., et al.: Clin. Chem. Lab. Med., 36, 803 (1998), El-Haj, B., et al.: J. Anal. Toxicol., 25, 316 (2001), Darzy, K., et al.: Clin. Endocrinol., 70, 287 (2009),<br></p>Formula:C14H10BrN3O2Colore e forma:Off-WhitePeso molecolare:332.157-Chloro-1-methyl-5-phenyl-[1,2,4]triazolo[4,3-a]quinolin-4-amine
CAS:<p>Applications An impurity of Alprazolam (A575650). The major degradation product in Alprazolam tablets during their stability assay.<br>References Nudelman, N., et al.: J. Pharm. Sci., 91, 1274 (2002), Marin, A., et al.: Anal. Chem., 77, 471 (2005),<br></p>Formula:C17H13ClN4Colore e forma:White To Off-WhitePeso molecolare:308.76Brotizolam
CAS:Prodotto controllato<p>Applications A hypnotic and a sedative, also used in veterinary medicine as an appetite stimulant<br>References Sato, T., et al.: J. Med. Chem., 51, 7705 (2008), Nishino, T., et al.: J. Pharmacol. Sci., 107, 349 (2008), Yamashiro, T., et al.: J. Clin. Pharm, Ther., 33, 273 (2008), Ma, C., et al.: J. Pharm. Biomed. Anal., 47, 677 (2008),<br></p>Formula:C15H10BrClN4SColore e forma:WhitePeso molecolare:393.69Nitrazepam
CAS:Prodotto controllato<p>Applications Anticonvulsant; hypnotic.Controlled substance (depressant).<br>References Rieder, et al.: Arzneim.-Forsch., 23, 212 (1973), Kangas, L., Acta Pharmacol. Toxicol., 45, 16 (1979), Aboul-Enein, H.Y., et al.: Anal. Profiles Drug Subs., 9, 487 (1980).<br></p>Formula:C15H11N3O3Colore e forma:White To Off-WhitePeso molecolare:281.273-Hydroxy Bromazepam 1.0 mg/mL in Methanol
CAS:Prodotto controllatoFormula:C14H10BrN3O2Colore e forma:ColourlessPeso molecolare:332.157-Fluoro-3,4-dihydro-4-methyl-1H-1,4-benzodiazepine-2,5-dione
CAS:Prodotto controllatoFormula:C10H9FN2O2Colore e forma:NeatPeso molecolare:208.191-Methyl-5-phenyl-1,3-dihydro-2H-benzo[e][1,4]diazepin-2-one
CAS:Purezza:98%Peso molecolare:250.30099487304688(S)-Methyl 3-(7-bromo-2-oxo-5-(pyridin-2-yl)-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)propanoate
CAS:Purezza:97.0%Peso molecolare:402.247985839843753-AMINO-1-METHYL-5-PHENYL-1H-BENZO[E][1,4]DIAZEPIN-2(3H)-ONE
CAS:Purezza:95.0%Colore e forma:SolidPeso molecolare:265.3160095214844Defluoro 8-Hydroxy Flumazenil
CAS:Prodotto controllatoFormula:C15H15N3O4Colore e forma:NeatPeso molecolare:301.30(R)-3-amino-9-fluoro-5-phenyl-1H-benzo[e][1,4]diazepin-2(3H)-one
Purezza:97%Peso molecolare:269.27899169921875Ref: 10-F790109
1gPrezzo su richiesta50mgPrezzo su richiesta100mgPrezzo su richiesta250mgPrezzo su richiesta2H-1,4-Benzodiazepin-2-one, 3-amino-1,3-dihydro-5-phenyl-, (3S)-
CAS:Purezza:98%Peso molecolare:251.289Cloxazolam
CAS:Prodotto controllato<p>Applications Cloxazolam is a benzodiazepine derivative with anxiolytic, hypnotic and antihypertensive properties used as an anti-anxiety drug. It is metabolized into the active metabolite Delorezepam (D230675). Controlled Substance.<br>References Oliveira-Silva, D. et al.: Biomed. Chrom., 23, 1266 (2009); Kamioka, T. et al.: Psychopharmacol., 52, 17 (1977); Fischer-Cornelssen, K.A. et al.: Arzneim.-Forsch., 31, 1757 (1981);<br></p>Formula:C17H14Cl2N2O2Colore e forma:NeatPeso molecolare:349.213-Amino-5-phenyl-1H-benzo[e][1,4]diazepin-2(3H)-one
CAS:Purezza:95.0%Peso molecolare:251.289001464843757-bromo-5-phenyl-1,3-dihydro-2H-benzo[e][1,4]diazepin-2-one
CAS:Purezza:95.0%Peso molecolare:315.17001342773447-methyl-5-phenyl-1,3,4,5-tetrahydro-2H-benzo[e][1,4]diazepin-2-one
CAS:Purezza:95.0%Peso molecolare:252.317001342773444-(2-Benzoyl-4-chlorophenyl)-5-methyl-4H-1,2,4-triazole-3-carboxaldehyde
CAS:Prodotto controllatoFormula:C17H12ClN3O2Colore e forma:NeatPeso molecolare:325.758-Chloro-5,6-dihydro-5-methyl-6-oxo-4H-Imidazo[1,5-a][1,4]benzodiazepine-3-carboxylic Acid Ethyl Ester
CAS:Prodotto controllato<p>Impurity Flumazenil EP Impurity F<br>Applications 8-Chloro-5,6-dihydro-5-methyl-6-oxo-4H-Imidazo[1,5-a][1,4]benzodiazepine-3-carboxylic Acid Ethyl Ester is an impurity of Flumazenil (F500450), an imidazodiazepine which selectively blocks the central effects of classic benzodiazepines.<br>References Hunkeler, W., et al.: Nature, 290, 514 (1981), Pole, P., et al.: Arch. Pharmacol., 316, 317 (1981), Timm, U., et al.: Arzneim.-Forsch., 33, 358 (1983),<br></p>Formula:C15H14ClN3O3Colore e forma:NeatPeso molecolare:319.74
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