Flavonoidi e Polifenoli

<p>Applications Protected Curcumin (C838500). A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. Induces apoptosis in cancer cells and inhibits phorbol ester-induced protein kinase C (PKC) activity. Reported to inhibit production of inflammatory cytokines by peripheral blood monocytes and alveolar macrophages. Potent inhibitor of EGFR tyrosine kinase and IκB kinase. Inhibits inducible nitric oxide synthase (iNOS), cycloxygenase and lipoxygenase. Easily penetrates into the cytoplasm of cells, accumulating in membranous structures such as plasma membrane, endoplasmic reticulum and nuclear envelope.<br>References Srinivasan, et al.: J. Pharm. Pharmacol., 5, 448 (1953), Tu, B., et al.: J .Cell Biol., 164, 341 (2004), Xu, G., et al.: Biochemistry, 44, 9817 (2005), Johnson, J., et al.: Cancer Lett., 255, 170 (2007),<br></p>

<p>Stability Light Sensitive<br>Applications 4'-O-Methylresveratrol is an impurity of resveratrol (R150000), an anticancer agent that has been shown to inhibit events associated with tumor initiation, promotion and progression.<br>References Powell, R.G., et al.: Phytochemistry, 35, 335 (1994), Jeandet, P., et al.: J. Phytopathol., 143, 135 (1995), Mattivi, F., et al.: J. Agric. Food Chem., 43, 1820 (1995),<br></p>

<p>Stability Light Sensitive<br>Applications Cannflavin A exhibits cyclooxygenase and lipoxygenase inhibition; some of its constituents have anti-inflammatory therapeutic potential.<br>References Evans, A.; et al.: Biochem. Pharmacol, 36, 2035 (1987)<br></p>

<p>Applications Exhibits specific inhibitory activity against tyrosine kinases,including autophosphorylation of epidermal growth factor receptor kinase (IC50 - 2.6uM). Also inhibits other protein kinases through competitive inhibition of ATP. Inhibits tumor cell proliferation and induces tumor cell differentiation. Produces cell-cycle arrest and apoptosis in Jurat T-leukemia cells. However, it prevents anti-CD3 monoclonal antibody-induced thymic apoptosis. Genistein also inhibits topoisomerase II activity in vitro. Genistein has also been shown to inhibit the action of GABA on recombinant GABAA receptors2. uv(max)ethanol: 262.5 nm (e= 138). moderately sol. in hot alcohol<br>References Akiyama, T., et al.: J. Biol. Chem., 262, 5592 (1987), O'Dell, T.J., et al.: Nature, 353, 588 (1991), Aharonovits, O., et al.: Biochim Biophys. Acta, 1112, 181 (1992), Platanias, L.C., et al.: J. Biol. Chem., 267, 24053 (1992), Yoshida, H., et al.: Biochim. Biophys. Acta, 1137, 321 (1992), Uckun, F.M., et al.: Science, 267, 886 (1995)Merck Index 12th ed. 43952. Huang, R.Q.; Fang, M.J.; Dillon, G.H., Mol. Brain Res. 67: 177-183 (1999)<br></p>

<p>Stability Hygroscopic<br>Applications Urolithin D is used in biological studies to evaluate DNA gyrase inhibitory activity of ellagic acid derivatives.<br>References Weidner-Weels, M. A., et al: Bioorg. Med. Chem. Lett., 8, 97 (1998)<br></p>

<p>Applications Secoisolariciresinol diglucoside (SDG) is a lignan found in flaxseed and is an emerging source in the functional food area. Flaxseed is the richest source of the lignan secoisolariciresinol diglucoside (SDG). SDG metabolites may protect against CVD and the metabolic syndrome by reducing lipid and glucose concentration, lowering blood pressure, and decreasing oxidative stress and inflammation.<br>References Lucas, E., et al.: J. Clin. Endocrinol Metab., 87, 1527 (2002), Choo, W., et al.: J. Food Compost. Anal., 20, 202 (2007), Sicilia, T., et al.: J. Agric. Food Chem., 51, 1181 (2003),<br></p>

<p>Applications Khellin is a compound present in the kella or picktooth fruit, used as a muscle relaxant.<br>References Shinde, P. et al.: Indian J. Nat. Prod. Res., 5, 40 (2014); Sztiller-Sikorska, M. et al.:<br></p>

<p>Riboflavin Tetrabutyrate is a lipophilic flavin derivative. Riboflavin Tetrabutyrate has antioxidative and lipid peroxide-removing activity.</p>

<p>Pyrogallol triacetate is used as an antiasthmatic.</p>

<p>Licodione is a Cytochrome P450 Monooxygenase Catalyzing 2-Hydroxylation of 5-Deoxyflavanone.</p>

<p>Leptospermone is an essential oil from Leptospermum scoparium (manuka oil).</p>

<p>(E)-Cinnamamide (trans-Cinnamamide) is the less active isomer of Cinnamamide which is an effective non-lethal chemical repellent suitable for reducing avian</p>

<p>Isosalipurposide, a chalcone compound, exerts a cytoprotective effect against oxidative injury via Nrf2 activation.</p>

<p>RS-0406: A β-flake blocker, reverses Aβ toxicity, protects in vitro, and halts behavior decline in vivo.</p>

<p>5,7-Dihydroxycoumarin is a natural product isolated from the dichloromethane extract of the inflorescences of Macaranga triloba.</p>

<p>Ensaculin, a benzopyrone-piperazine compound, enhances memory, protects neurons, and may treat dementia.</p>

<p>Luteolin 7-sulfate from Phyllospadix iwatensis inhibits melanin production by disrupting CREB/MITF signaling.</p>

<p>Equisetin: a QSI from Fusarium equiseti, curbs P. aeruginosa virulence, fights Gram-positive bacteria &amp; HIV-1 integrase; not antibacterial to Gram-negative.</p>

<p>Malvone A is a compound with antifungal properties found in Malva sylvestris, with an ED50 of 24 μg/mL against V. dahliae. It is applicable in research focused on anti-infective solutions.</p>