Flavonoidi e Polifenoli

<p>Stability Light Sensitive<br>Applications Cannflavin A exhibits cyclooxygenase and lipoxygenase inhibition; some of its constituents have anti-inflammatory therapeutic potential.<br>References Evans, A.; et al.: Biochem. Pharmacol, 36, 2035 (1987)<br></p>

<p>Applications 27-Deoxyactein has shown stimulation of osteoblast function and inhibits bone resorbing mediators in the treatment of osteoporosis. It is a derivative of Actein (A191800), a gamma secretase modulators derived from botanicals.<br>References Choi, E. et al. J. App. Toxicol., 33, 190 (2010); Findeis, M. et al.: ACS. Chem. Neurosci., 3, 941 (2012); Einbond, L. et al.: Fund. Clin. Pharm., 23, 311 (2009);<br></p>

<p>Applications Protected Curcumin (C838500). A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. Induces apoptosis in cancer cells and inhibits phorbol ester-induced protein kinase C (PKC) activity. Reported to inhibit production of inflammatory cytokines by peripheral blood monocytes and alveolar macrophages. Potent inhibitor of EGFR tyrosine kinase and IκB kinase. Inhibits inducible nitric oxide synthase (iNOS), cycloxygenase and lipoxygenase. Easily penetrates into the cytoplasm of cells, accumulating in membranous structures such as plasma membrane, endoplasmic reticulum and nuclear envelope.<br>References Srinivasan, et al.: J. Pharm. Pharmacol., 5, 448 (1953), Tu, B., et al.: J .Cell Biol., 164, 341 (2004), Xu, G., et al.: Biochemistry, 44, 9817 (2005), Johnson, J., et al.: Cancer Lett., 255, 170 (2007),<br></p>

<p>Applications Diosmetin 3’,7-Diglucuronide-d3 is labelled Diosmetin 3’,7-Diglucuronide (D485040), a metabolite of Diosmetin (D485000) which is a flavonoid often administered in the treatment of chronic venous insufficiency, hemorrhoids, and related affections.<br>References Silverstro, L., et al.: Anal. Bioanal. Chem., 405, 8295 (2013); Boutin, J., et al.; Drug Metab. Dispos., 21, 1157 (1993)<br></p>

<p>Stability Hygroscopic, Moisture Sensitive<br>Applications Triclosan O-Sulfate is a metabolite of the bacteriostat, Triclosan (T774250).<br>References Wu, J. et al.: Sepu, 27, 724 (2009);<br></p>

<p>Applications A metabolite of trans Resveratrol.<br>References Banerjee, S., et al.: Cancer Res., 62, 4945 (2002), Wang, L., et al.: J. Pharm. Sci., 93, 2448 (2004), Provinciali, M., et al.: Int. J. Cancer, 115, 36 (2005), Lancon, A., et al.: Drug Metab. Dispos., 35, 699 (2007),<br></p>

<p>Stability Light Sensitive<br>Applications Urolithin B Glucuronide counteracts trimethylamine-N-oxide (TMAO)-induced cell damage and other detrimental effects of the cardiovascular systems triggered by TMAO.<br>References Savi, M., et al.: Molecules, 23, 549 (2018)<br></p>

<p>Applications Khellin is a compound present in the kella or picktooth fruit, used as a muscle relaxant.<br>References Shinde, P. et al.: Indian J. Nat. Prod. Res., 5, 40 (2014); Sztiller-Sikorska, M. et al.:<br></p>

<p>RS-0406: A β-flake blocker, reverses Aβ toxicity, protects in vitro, and halts behavior decline in vivo.</p>

<p>Licodione is a Cytochrome P450 Monooxygenase Catalyzing 2-Hydroxylation of 5-Deoxyflavanone.</p>

<p>Riboflavin Tetrabutyrate is a lipophilic flavin derivative. Riboflavin Tetrabutyrate has antioxidative and lipid peroxide-removing activity.</p>

<p>Pyrogallol triacetate is used as an antiasthmatic.</p>

<p>5,7-Dihydroxycoumarin is a natural product isolated from the dichloromethane extract of the inflorescences of Macaranga triloba.</p>

<p>Leptospermone is an essential oil from Leptospermum scoparium (manuka oil).</p>

<p>(E)-Cinnamamide (trans-Cinnamamide) is the less active isomer of Cinnamamide which is an effective non-lethal chemical repellent suitable for reducing avian</p>

<p>Isosalipurposide, a chalcone compound, exerts a cytoprotective effect against oxidative injury via Nrf2 activation.</p>

<p>Ensaculin, a benzopyrone-piperazine compound, enhances memory, protects neurons, and may treat dementia.</p>

<p>Luteolin 7-sulfate from Phyllospadix iwatensis inhibits melanin production by disrupting CREB/MITF signaling.</p>

<p>Malvone A is a compound with antifungal properties found in Malva sylvestris, with an ED50 of 24 μg/mL against V. dahliae. It is applicable in research focused on anti-infective solutions.</p>

<p>Equisetin: a QSI from Fusarium equiseti, curbs P. aeruginosa virulence, fights Gram-positive bacteria &amp; HIV-1 integrase; not antibacterial to Gram-negative.</p>