Fosfati e Fosfonati Organici
I fosfati organici sono composti che contengono un gruppo fosfato (-PO₄) legato a un atomo di carbonio in una struttura organica, solitamente in combinazione con alcoli, acidi o ammine. Questi composti vengono utilizzati nella formulazione di API per migliorare la solubilità, la stabilità e la biodisponibilità dei principi attivi. I fosfati organici trovano anche applicazione nel rilascio controllato dei farmaci e nel miglioramento dell'assorbimento di alcuni medicinali.
I fosfonati organici contengono un gruppo fosfonato (-PO₃H₂) in cui l'atomo di fosforo è legato a un atomo di carbonio e a due gruppi ossigeno. Questi composti possiedono proprietà farmacologiche importanti, in particolare nell'inibizione degli enzimi e nella modulazione dei processi biochimici. I fosfonati organici vengono utilizzati nella produzione di API che agiscono sul metabolismo osseo, sulle infezioni batteriche o nei trattamenti antivirali grazie ai loro specifici effetti biologici.
Presso CymitQuimica, offriamo fosfati e fosfonati organici per la ricerca in chimica medica, biochimica e sviluppo di formulazioni avanzate.
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Ref: 4Z-T-181001
5mgPrezzo su richiesta10mgPrezzo su richiesta25mgPrezzo su richiesta50mgPrezzo su richiesta100mgPrezzo su richiestaRef: 4Z-T-251001
5mgPrezzo su richiesta10mgPrezzo su richiesta25mgPrezzo su richiesta50mgPrezzo su richiesta100mgPrezzo su richiestaRef: 4Z-P-5426
5mgPrezzo su richiesta10mgPrezzo su richiesta25mgPrezzo su richiesta50mgPrezzo su richiesta100mgPrezzo su richiestaRef: 4Z-T-181002
5mgPrezzo su richiesta10mgPrezzo su richiesta25mgPrezzo su richiesta50mgPrezzo su richiesta100mgPrezzo su richiestaMalathion β-Monoacid
CAS:<p>Stability Hygroscopic<br>Applications A major biodegradation product of Malathion (M111000).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Kim, Y. et al.: Chemosphere, 60, 1349 (2005); Yoshii, K. et al.: J. Health Sci., 54, 535 (2008); Hayasaka, M. et al.: Jap. J. Forensic Toxicol., 12, 15 (1994);<br></p>Formula:C8H15O6PS2Colore e forma:NeatPeso molecolare:302.30Sodium hydrogen (4-amino-1-hydroxy-1-phosphonobutyl)phosphonate
CAS:Purezza:95.0%Colore e forma:Solid, White - Almost white powderPeso molecolare:271.0769958496094(Dichloromethylene)diphosphonic acid, disodium salt
CAS:Purezza:95.0%Colore e forma:Solid, No data available.Peso molecolare:288.8500061035156Ref: 10-F449661
1gPrezzo su richiesta5gPrezzo su richiesta10gPrezzo su richiesta25gPrezzo su richiesta100gPrezzo su richiesta200mgPrezzo su richiestaEthyl Dihydrogen Phosphate
CAS:Prodotto controllatoFormula:C2H7O4PColore e forma:White To BeigePeso molecolare:126.048Sodium (2R,3R,4S)-2,3,4,6-tetrahydroxy-5-oxohexyl phosphate
CAS:Purezza:95.0%Peso molecolare:322.004171806(2,7-di-tert-Butyl-9-methyl-9H-fluoren-9-yl)phosphonic acid
CAS:Purezza:98%Peso molecolare:372.44500732421875Sodium (3-amino-1-hydroxy-1-phosphonopropyl)phosphonate xhydrate
CAS:Purezza:95.0%Colore e forma:Solid, No data available.Peso molecolare:297.0469970703125Ref: 10-F431320
1gPrezzo su richiesta5gPrezzo su richiesta10gPrezzo su richiesta25gPrezzo su richiesta50mgPrezzo su richiesta250mgPrezzo su richiesta4-(1,2,2-Tris(4-(phosphonooxy)phenyl)vinyl)phenyl dihydrogen phosphate
CAS:Purezza:98%Peso molecolare:716.3569946289062(S)-TETRAHYDROFURAN-3-YL ((2S,3R)-4-(4-AMINO-N-ISOBUTYLPHENYLSULFONAMIDO)-1-PHENYL-3-(PHOSPHONOOXY)BUTAN-2-YL)CARBAMATE
CAS:Purezza:99%Peso molecolare:585.6099853515625Ref: 10-F824417
1mgPrezzo su richiesta5mgPrezzo su richiesta10mgPrezzo su richiesta25mgPrezzo su richiesta50mgPrezzo su richiesta100mgPrezzo su richiestaRef: 10-F772968
1gPrezzo su richiesta5gPrezzo su richiesta25gPrezzo su richiesta100mgPrezzo su richiesta250mgPrezzo su richiestaRef: 10-F240165
1gPrezzo su richiesta10mgPrezzo su richiesta50mgPrezzo su richiesta250mgPrezzo su richiesta(2-Bromoethyl)phosphonic acid
CAS:Purezza:95.0%Colore e forma:SolidPeso molecolare:188.94500732421875Ref: 10-F759946
1gPrezzo su richiesta5gPrezzo su richiesta100mgPrezzo su richiesta250mgPrezzo su richiesta3-(Methylnitrosamino)propionitrile
CAS:Prodotto controllato<p>Applications 3-(Methylnitrosamino)propionitrile (MNPN) was detected for the 1st time in the saliva of betel quid chewers and is a potent carcinogen.<br>References Bartsch, H., et al.: Mutat. Res., 250, 103 (1991), Su, T., et al.: Drug Metab. Dispos., 24, 884 (1996), Guengerich, F., et al.: Chem. Res. Toxicol., 14, 611 (2001),<br></p>Formula:C4H7N3OColore e forma:Light YellowPeso molecolare:113.12Triisopropyl Phosphate
CAS:Prodotto controllato<p>Applications Triisopropyl Phosphate can be used as a flame retardant and catalyst.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Zhang, Tie-jiang.: Meitan Jishu,29(2), 204-206 (2010);Chen, Yong-Fu, et al.: Jingxi Huagong, 17(9), 541-543 (2000)<br></p>Formula:C9H21O4PColore e forma:NeatPeso molecolare:224.23Risedronic Acid-d4 (Major)
CAS:Prodotto controllatoFormula:C7H7D4NO7P2Colore e forma:NeatPeso molecolare:287.14Alendronic Acid-d6 (Major)
CAS:Prodotto controllatoFormula:C4D6H7NO7P2Colore e forma:NeatPeso molecolare:255.13Metaraminol Bitartrate
CAS:Prodotto controllato<p>Applications Metaraminol Bitartrate is a vasopressor comparable to ephedrine used in the maintenance of arterial pressure during spinal anesthesia. Also used in the treatment of hypotension while under the effect of anaesthesia.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Ngan, K. et al.: Anesthes., 95, 307 (2001); Critchley, L. et al.: Br. J. Anaesth., 76, 734 (1996);<br></p>Formula:C9H13NO2·C4H6O6Colore e forma:WhitePeso molecolare:317.29Ref: 10-F760024
1gPrezzo su richiesta5gPrezzo su richiesta100mgPrezzo su richiesta250mgPrezzo su richiesta(4-Amino-1-hydroxybutane-1,1-diyl)diphosphonic acid
CAS:Purezza:95.0%Colore e forma:Solid, White to slightly pale yellow powderPeso molecolare:249.0959930419922Cyclophosphamide-d8 H2O [bis(2-chloroethyl-d4)]
CAS:Prodotto controllato<p>Applications Cyclophosphamide-d8 H2O [bis(2-chloroethyl-d4)] is a useful isotopically labeled compound of Cyclophosphamide Monohydrate (C988580)<br></p>Formula:C7H9D8Cl2N2O3PColore e forma:White To Off-WhitePeso molecolare:287.15Diazinon
CAS:Prodotto controllato<p>Stability Moisture Sensitive<br>Applications A cholinesterase inhibitor; a nonsystemic organophosphate insecticide. This compound is a contaminant of emerging concern (CECs). Used as a standard for Pesticide detection.Diazinon is useful in cannabis testing kits as a component of pesticide mixes (P698230).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Gaines, T.B., et al.: Toxicol. Appl. Pharmacol., 14, 515 (1969);<br></p>Formula:C12H21N2O3PSColore e forma:ColourlessPeso molecolare:304.35Cyclophosphamide-d4
CAS:Prodotto controllato<p>Applications It is a cytotoxic nitrogen mustard derivative widely used in cancer chemotherapy. It cross-links DNA, causes strand breakage, and induces mutations. Its clinical activity is associated with a decrease in aldehyde dehydrogenase 1 (ALDH1) activity. This substance is listed as a known human carcinogen.This compound is suitable for aldehyde dehydrogenase (ALDH) related research.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Wheeler, A.G., et al.: Toxicol. Appl. Pharmacol., 4, 324 (1962), Fraiser, L.H., et al.: Drugs, 42, 781 (1991), Colvin, O.M., et al.: Curr. Pharmaceut. Design, 5, 555 (1999),<br></p>Formula:C72H4H11Cl2N2O2PColore e forma:Off-WhitePeso molecolare:265.11Amifostine Thiol Dihydrochloride >90%
CAS:<p>Stability Hygroscopic<br>Applications Amifostine Thiol is a metabolite of Amifostine (A576810) which provides normal cells with selective protection against the toxic effects of cancer chemotherapy and radiation treatment.<br>References Satge, J., et al.: Eur. J. Med. Chem., 24, 48 (1989); Geary, R.S., et al.: Biopharm. Drug Dispos., 12, 261 (1991); Brown, D.Q., et al. Pharmacol. Ther., 39, 159 (1988); Capizzi, R.L., et al.: Cancer, 72, 3495 (1993); Treskes, M., et al.: Cancer Chemother. Pharmacol., 33, 93 (1993)<br></p>Formula:C5H14N2S·2ClHPurezza:>90%Colore e forma:NeatPeso molecolare:207.16Carboxyphosphamide-d4
CAS:Prodotto controllato<p>Applications A labelled metabolite of Cyclophosphamide (CPA) (C988580).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Takamizawa, A., et al.: J. Med. Chem., 18, 376 (1975), Jones, R.J., et al.: J. Hematother., 1, 343 (1992), Biggs, D., et al.: Prog. Clin. Biol. Res., 389, 9 (1994),<br></p>Formula:C7H11D4Cl2N2O4PColore e forma:NeatPeso molecolare:297.11(R,S)-4-Hydroxy Cyclophosphamide Preparation Kit
CAS:<p>Stability Unstable in Solution<br>Applications A metabolite of Cyclophosphamide.This Kit consists of a vial of the precursor, 4-hydroperoxycyclophosphamide (H714675), and a vial of sodium thiosulfate (S673640). Simply add water to the reducing agent until it is completely dissolved and add this solution to the precursor. This solution has a half-life of approximately 200 minutes at room temperature. Detailed instructions are enclosed.<br>References Peter, G., et al.: Cancer. Chemother. Pharmacol., 3, 181 (1979), Fenselau, C., et al.: Drug Metab. Dispos., 10, 636 (1982), Gamcsik, M., et al.: J. Med. Chem., 33, 1009 (1990), Habib, A., et al.: Biochem. Pharmacol., 50, 429 (1995),<br></p>Formula:C7H15Cl2N2O3PColore e forma:Off White CrystallinePeso molecolare:277.09Malathion α-Monoacid
CAS:Prodotto controllato<p>Stability Moisture Sensitive<br>Applications A major biodegradation product of Malathion (M111000).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Kim, Y. et al.: Chemosphere, 60, 1349 (2005); Yoshii, K. et al.: J. Health Sci., 54, 535 (2008); Hayasaka, M. et al.: Jap. J. Forensic Toxicol., 12, 15 (1994);<br></p>Formula:C8H15O6PS2Colore e forma:NeatPeso molecolare:302.3Zoledronic Acid Disodium Salt Tetrahydrate
CAS:Prodotto controllato<p>Applications A biphosphonate bone resorption inhibitor.<br>References Green, J.R., et al.: J. Bone Min. Res., 9, 745 (1994), Risser, F., et al.: J. Pharm. Biomed. Anal., 15, 1877 (1997), Body, J.J., Cancer, 80, 1699 (1997),<br></p>Formula:C5H8N2O7P2·2Na·4H2OColore e forma:NeatPeso molecolare:388.11Imidazol-1-yl-acetic Acid
CAS:Prodotto controllato<p>Applications An impurity arising in the synthesis of zoledronic acid (Z623500).<br></p>Formula:C5H6N2O2Colore e forma:BeigePeso molecolare:126.115-Decyano 5-Carboxymilrinone
CAS:Prodotto controllato<p>Impurity Milrinone Impurity 12<br>Applications 5-Decyano 5-Carboxymilrinone (Milrinone Impurity 12) is an impurity of Milrinone (M344680), a selective phosphodiesterase inhibitor with vasodilating and positive inotropic activity.<br>References Alousi, A.A., et al.: J. Cardiovasc Pharmacol., 5, 792 (1983); Maskin, C.S., et al.: Circulation, 67, 1065 (1983); Sinoway, L.S., et al.: J. Am. Coll. Cardiol., 2, 327 (1983); Baim, D.S., et al.: N. Engl. J. Med., 309, 748 (1983)<br></p>Formula:C12H10N2O3Colore e forma:Off-WhitePeso molecolare:230.22Deferasirox Methyl Ester
CAS:Prodotto controllato<p>Applications Deferasirox Methyl Ester is a derivative of Deferasirox (D228650); an orally active tridentate iron chelator.<br>References Hershko, C., et al.: Blood, 97, 1115 (2001); Galanello, R., et al.: J. Clin. Pharmacol., 43, 565 (2003); Nick, H., et al.: Curr. Med. Chem., 10, 1065 (2003)<br></p>Formula:C22H17N3O4Colore e forma:White To BeigePeso molecolare:387.39Parathion
CAS:Prodotto controllato<p>Stability Hygroscopic, Moisture Sensitive<br>Applications Parathion is an organophosphate insecticide used on cotton, rice and fruit trees.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Seifert, J., et al.: Environ. Toxicol. Pharmacol., 35, 200 (2013); Ciffroy, P., et al.: Environ. Toxicol. Chem., 32, 602 (2013);<br></p>Formula:C10H14NO5PSColore e forma:YellowPeso molecolare:291.26N-Dechloroethyl Cyclophosphamide
CAS:<p>Stability Reacts with DMSO<br>Applications A metabolite of Cyclophosphamide (C988580).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Bohnenstengel, F., et al.: Eur. J. Clin. Pharmacol., 51, 297 (1996), Busse, D., et al.: J. Clin. Oncol., 15, 188 (1997), Roy, P., et al.: Drug Metab. Dispos., 27, 655 (1999),<br></p>Formula:C5H12ClN2O2PColore e forma:NeatPeso molecolare:198.59(R,S)-4-Hydroxy Cyclophosphamide-d4 Preparation Kit
CAS:Prodotto controllatoFormula:C7H11D4Cl2N2O3PColore e forma:White To Off-WhitePeso molecolare:281.11(S)-(-)-3-Acetylthio-2-methylpropionic Acid
CAS:Prodotto controllato<p>Applications S-Acetylthio-2-methylpropionic Acid (S-AMPA) is a key chiral intermediate for Captopril (C175750) and other hypertension drugs.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Cushman, D., et al.: Biochem., 16, 5484 (1977), Ondetti, M., et al.: J. Med. Chem., 24, 355 (1981), Tseng, T., et al.: Cancer Lett., 62, 233 (1992),<br></p>Formula:C6H10O3SColore e forma:ColourlessPeso molecolare:162.214-Ethoxy-2-isopropyl-6-methylpyrimidine
CAS:Prodotto controllato<p>Applications 4-Ethoxy-2-isopropyl-6-methylpyrimidine, is the product of Diazinon (D416880) decomposition, an organophosphorus pesticide.<br>References Mekhakyan, L. A., et al.: Nov. Khim. Sredstva Zashch. , 62 (1979); Sovocool, G. W., et al.: J. Anal. Toxic., 5, 73 (1981);<br></p>Formula:C10H16N2OColore e forma:NeatPeso molecolare:180.25Bis(2-chloroethyl)-1,1,2,2-d4-amine Hydrochloride
CAS:Prodotto controllato<p>Applications Isotope labelled Bis(2-chloroethyl)amine is a cytotoxic metabolite of Cyclophosphamide; a deuterated analog of Nor-nitrogen mustard.<br>References Colvin, M., et al.: Cancer Res., 36, 1121 (1976), Ludeman, S., et al.: Drug Metab Dispos., 20, 337 (1992), Ludeman, S.M., et al.: J. Pharmaceut. Sci., 84, 393 (1995), Yu, L., et al.: Drug Metab. Dispos., 24, 1254 (1996),<br></p>Formula:C42H4H5Cl2N·ClHColore e forma:NeatPeso molecolare:182.51Epicaptopril
CAS:<p>Stability Air Sensitive<br>Applications Epicaptopril is an impurity of Captopril (C175750) which is an orally active angiotensin-converting enzyme (ACE) inhibitor used in the treatment of hypertension and congestive heart failure.<br>References Rubin, B., et al.: Eur. J Pharmacol., 51, 377 (1978);<br></p>Formula:C9H15NO3SColore e forma:White To Off-WhitePeso molecolare:217.28Glufosinate-d3 Hydrochloride
CAS:Prodotto controllato<p>Stability Very Hygroscopic<br>Applications Labelled Glufosinate (G596952). Used as a herbicide.<br>References Abbas, H., et al.: J. Agric. Food Chem., 50, 5246<br></p>Formula:C52H3H9NO4P·ClHColore e forma:White To Light BeigePeso molecolare:220.61Captopril
CAS:Prodotto controllato<p>Stability Hygroscopic<br>Applications Orally active angiotensin-converting enzyme (ACE) inhibitor. Neuroprotective & Neuroresearch Product.<br>References Rubin, B., et al.: Eur. J Pharmacol., 51, 377 (1978),<br></p>Formula:C9H15NO3SColore e forma:NeatPeso molecolare:217.29Miltefosine
CAS:Prodotto controllato<p>Applications A phospholipid drug with antineoplastic and antiprotozoal/antifungal properties, also acts as an Akt inhibitor, and under investigation as a potential therapy against HIV infection.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Chugh, P., et al al.: Retrovirology, 5, 11 (2008), Dorio, T., et al.: Antimicrob. Agents Chemother., 52, 2855 (2008),<br></p>Formula:C21H46NO4PColore e forma:NeatPeso molecolare:407.57
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