Sali e Derivati degli API
I sali degli Ingredienti Farmaceutici Attivi (API) sono composti formati dalla reazione di un acido con una base, risultando in un equilibrio ionico. Questi sali migliorano spesso la solubilità e la stabilità degli API, facilitandone l’assorbimento nel corpo. I derivati degli API sono varianti chimiche di un principio attivo che possono presentare proprietà migliorate o modificate per ottimizzare l’efficacia terapeutica. I sali di API sono utilizzati nella formulazione di farmaci orali, iniettabili e topici. Inoltre, i derivati degli API possono migliorare la farmacocinetica dei farmaci, ad esempio consentendo un rilascio controllato dei principi attivi.
Presso CymitQuimica, offriamo sali e derivati di API con la purezza e la qualità necessarie per la ricerca e lo sviluppo di formulazioni farmaceutiche.
Trovati 79238 prodotti di "Sali e Derivati degli API"
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Hexadecyltrimethylammonium Bromide
CAS:<p>Applications Hexadecyltrimethylammonium Bromide (CTAB) is a cationic surfactant used as a template in the synthesis of Mesoporous γ-Fe2O3.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Yu, H.-h., et al.: Gongneng Cailiao, 42, 2005 (2011),<br></p>Formula:C19H42N·BrColore e forma:NeatPeso molecolare:364.45Probenecid-d14
CAS:Prodotto controllato<p>Applications Uricosuric.<br>References McKinney, S.E., et al.: J. Pharmacol. Exp. Ther., 102, 208 (1951), Israili, Z.H., et al.: J. Med. Chem., 15, 709 (1972), Al-Badr, A.A., et al.: Anal. Profiles Drug Subs., 10, 639 (1981), Cunningham, R.F., et al.: Clin. Pharmacokinet., 6, 135 (1981),<br></p>Formula:C13D14H5NO4SColore e forma:NeatPeso molecolare:299.45Ivermectin B1a-D2
CAS:Prodotto controllato<p>Applications Ivermectin B1a-D2 is a deuterium labelled analogue of Ivermectin B1a (I940815), which is a major component of Ivermectin (I940800), a semi-synthetic derivative of Abamectin; consists of a mixture of not less than 80% component B1a and not more than 20% component B1b. Antihelmintic (Onchocerca). An invitro inhibitor of SARS-CoV-2/ Covid-19.<br>References Chabala, J.C., et al.: J. Med. Chem., 23, 1134 (1980); Campbell, W.C., et al.: Science, 221, 823 (1983); Bennett, J.L., et al.: Parasitol. Today, 4, 226 (1988); Plaisier, A.P., et al.: J. Infect. Dis., 172, 204 (1995);; Caly, L., et al.: Antivir. Res., 178<br></p>Formula:C48H72D2O14Colore e forma:NeatPeso molecolare:877.115-Methylisoxazole-4-carboxylic Acid
CAS:Prodotto controllatoFormula:C5H5NO3Colore e forma:NeatPeso molecolare:127.10Apixaban PG Ester-I
CAS:Prodotto controllato<p>Applications Apixaban PG Ester-I is one of the multiple constituents extracted from Biebersteinia multifida, that exhibits inhibitory activity on acetylcholinesterase.<br>References Xiang, F., et al.: Faming Zhuanli Shenqing (2019), CN 109432093 A 20190308.<br></p>Formula:C28H30N4O6Colore e forma:NeatPeso molecolare:518.563-((2-Chloroethyl)amino)propyl Dihydrogen Phosphate
CAS:Prodotto controllato<p>Impurity Ifosfamide EP Impurity A<br>Applications 3-((2-Chloroethyl)amino)propyl Dihydrogen Phosphate is a metabolite of Ifosfamide (I265000), which is a cytostatic drug.<br>References Gilard, V., et al.: J. Med. Chem., 42, 2542 (1999);<br></p>Formula:C5H13ClNO4PColore e forma:WhitePeso molecolare:217.59Brinzolamide
CAS:Prodotto controllato<p>Applications Carbonic anhydrase inhibitor. Antiglaucoma agent.<br>References Silver, L.H., et al.: Am. J. Ophthalmol., 126, 400 (1998), Davies, N., et al.: Clin. Exp. Pharmacol. Physiol., 27, 558 (2000), Stave, J., et al.: Ophthalmologe, 99, 276 (2002),<br></p>Formula:C12H21N3O5S3Colore e forma:NeatPeso molecolare:383.51Ivermectin
CAS:Prodotto controllato<p>Applications Semi-synthetic derivative of Abamectin; consists of a mixture of not less than 80% component B1a and not more than 20% component B1b. Anthelmintic (Onchocerca).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Chabala, J.C., et al.: J. Med. Chem., 23, 1134 (1980); Campbell, W.C., et al.: Science, 221, 823 (1983); Bennett, J.L., et al.: Parasitol. Today, 4, 226 (1988); Plaisier, A.P., et al.: J. Infect. Dis., 172, 204 (1995);<br></p>Formula:C48H74O14·C47H72O14Colore e forma:White To Off-WhitePeso molecolare:1736.16Repaglinide Acyl-β-D-glucuronide
CAS:<p>Applications A metabolite of Repaglinide (M7).<br></p>Formula:C33H44N2O10Colore e forma:NeatPeso molecolare:628.71Tolvaptan
CAS:Prodotto controllato<p>Applications Tolvaptan is a selective, competitive arginine vasopressin V2 receptor antagonist used to treat hyponatremia (low blood sodium levels) associated with congestive heart failure, cirrhosis, and the syndrome of inappropriate antidiuretic hormone (SIADH).<br>References Paterna, S., et al.: Eur. J. Heart Fail, 2, 305 (2000); Udelson, J., et al.: Circulation, 104, 2417 (2001); Goldsmith, S., et al.: J. Am. Coll Cardiol., 46, 1785 (2005); Schrier, R., et al.: N. Engl. J. Med., 355, 2099 (2006);<br></p>Formula:C26H25ClN2O3Colore e forma:White To Off-WhitePeso molecolare:448.94Ref: ST-EA-CP-R36032
10mgPrezzo su richiesta25mgPrezzo su richiesta50mgPrezzo su richiesta100mgPrezzo su richiestaRef: ST-EA-CP-T179005
10mgPrezzo su richiesta25mgPrezzo su richiesta50mgPrezzo su richiesta100mgPrezzo su richiestaRef: ST-EA-CP-NIT269
10mgPrezzo su richiesta25mgPrezzo su richiesta50mgPrezzo su richiesta100mgPrezzo su richiestaMacitentan-d4
CAS:Prodotto controllato<p>Applications Macitentan-d4 is an isotopic form of Macitentan (M105005). Macitentan, is an orally active endothelin receptor antagonist used for pulmonary arterial hypertension.<br>References Emoto, N. Ensho to Men'eki, 20, 487 (2012);<br></p>Formula:C19H16D4Br2N6O4SColore e forma:NeatPeso molecolare:592.3Ref: ST-EA-CP-S18126
10mgPrezzo su richiesta25mgPrezzo su richiesta50mgPrezzo su richiesta100mgPrezzo su richiestaRef: ST-EA-CP-P74035
10mgPrezzo su richiesta25mgPrezzo su richiesta50mgPrezzo su richiesta100mgPrezzo su richiestaCyclosporin B
CAS:<p>Applications An immunosuppressant that has revolutionized organ transplantation through its use in the prevention of graft rejection.A group of nonpolar cyclic oligopeptides with immunosupppressant activity.<br>References van Wartburg, A., et al.: Prog. Med. Chem., 25, 1 (1988), Jorgensen, K.A., et al.: Scand. J. Imunol., 57, 93 (2003), Vollenbroeker, et al.: Transplant. Proc., 37, 1741 (2005),<br></p>Formula:C61H109N11O12Purezza:>80%Colore e forma:NeatPeso molecolare:1188.58Ref: ST-EA-CP-NIT021
10mgPrezzo su richiesta25mgPrezzo su richiesta50mgPrezzo su richiesta100mgPrezzo su richiestaRef: ST-EA-CP-NIT141
10mgPrezzo su richiesta25mgPrezzo su richiesta50mgPrezzo su richiesta100mgPrezzo su richiestaRef: ST-EA-CP-NIT017
10mgPrezzo su richiesta25mgPrezzo su richiesta50mgPrezzo su richiesta100mgPrezzo su richiestaRef: ST-EA-CP-NIT190
10mgPrezzo su richiesta25mgPrezzo su richiesta50mgPrezzo su richiesta100mgPrezzo su richiestaRef: ST-EA-CP-NIT044
10mgPrezzo su richiesta25mgPrezzo su richiesta50mgPrezzo su richiesta100mgPrezzo su richiestaRef: ST-EA-CP-NIT107
10mgPrezzo su richiesta25mgPrezzo su richiesta50mgPrezzo su richiesta100mgPrezzo su richiestaRef: ST-EA-CP-NIT022
10mgPrezzo su richiesta25mgPrezzo su richiesta50mgPrezzo su richiesta100mgPrezzo su richiestaRef: ST-EA-CP-NIT023
10mgPrezzo su richiesta25mgPrezzo su richiesta50mgPrezzo su richiesta100mgPrezzo su richiestaEltrombopag Olamine
CAS:<p>Stability Hygroscopic<br>Applications Eltrombopag is an agonist of the Thrombopoietin (Tpo) receptor, used as treatment for thrombocytopenia<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Bussel, J., et al.: New Eng. J. Med., 357, 2237 (2007), Marsilje, T., et al.: Bioorg. Med. Chem. Lett., 18, 5259 (2008), Alper, P., et al.: Bioorg. Med. Chem. Lett., 18, 5255 (2008)<br></p>Formula:C25H22N4O4·2C2H7NOColore e forma:Dark RedPeso molecolare:564.63Ref: ST-EA-CP-NIT046
10mgPrezzo su richiesta25mgPrezzo su richiesta50mgPrezzo su richiesta100mgPrezzo su richiestaRef: ST-EA-CP-NIT047
10mgPrezzo su richiesta25mgPrezzo su richiesta50mgPrezzo su richiesta100mgPrezzo su richiestaRef: ST-EA-CP-NIT143
10mgPrezzo su richiesta25mgPrezzo su richiesta50mgPrezzo su richiesta100mgPrezzo su richiestaRef: ST-EA-CP-NIT160
10mgPrezzo su richiesta25mgPrezzo su richiesta50mgPrezzo su richiesta100mgPrezzo su richiestaRef: ST-EA-CP-N7001
10mgPrezzo su richiesta25mgPrezzo su richiesta50mgPrezzo su richiesta100mgPrezzo su richiestaRef: ST-EA-CP-NIT020
10mgPrezzo su richiesta25mgPrezzo su richiesta50mgPrezzo su richiesta100mgPrezzo su richiestaRef: ST-EA-CP-NIT145
10mgPrezzo su richiesta25mgPrezzo su richiesta50mgPrezzo su richiesta100mgPrezzo su richiestaRef: ST-EA-CP-NIT031
10mgPrezzo su richiesta25mgPrezzo su richiesta50mgPrezzo su richiesta100mgPrezzo su richiestaRef: ST-EA-CP-M28009
10mgPrezzo su richiesta25mgPrezzo su richiesta50mgPrezzo su richiesta100mgPrezzo su richiestaTolvaptan-d7
CAS:Prodotto controllato<p>Applications Labelled Tolvaptan. It is a selective, competitive arginine vasopressin V2 receptor antagonist used to treat hyponatremia (low blood sodium levels) associated with congestive heart failure, cirrhosis, and the syndrome of inappropriate antidiuretic hormone (SIADH).<br>References Paterna, S., et al.: Eur. J. Heart Fail, 2, 305 (2000), Udelson, J., et al.: Circulation, 104, 2417 (2001), Goldsmith, S., et al.: J. Am. Coll Cardiol., 46, 1785 (2005), Schrier, R., et al.: N. Engl. J. Med., 355, 2099 (2006),<br></p>Formula:C26H18D7ClN2O3Colore e forma:NeatPeso molecolare:455.985-Methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine-2-carboxylic Acid Hydrochloride
CAS:Prodotto controllato<p>Stability Hygroscopic<br>Applications 5-Methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine-2-carboxylic Acid Hydrochloride is used as a reagent in the synthesis of N-(2-acylaminobenzyl or 2-acylaminoheterocyclylmethyl)thiophene-2-carboxamide derivatives as antithrombotics. It is also used as a reagent in the synthesis of diamide derivatives as FXa inhibitors. 5-Methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine-2-carboxylic Acid Hydrochloride is an intermediate for Edoxaban (E555520).<br>References Mochizuki, A., et al.: Jpn. Kokai Tokkyo Koho. JP 2010120852 A 20100603. Jun 3, 2010; Mochizuki, A., et al.: PCT Int. Appl. WO 2008123017 A1 20081016. Oct 16, 2008<br></p>Formula:C8H11ClN2O2SColore e forma:Light BrownPeso molecolare:234.7Bimatoprost-d5
CAS:Prodotto controllato<p>Applications Labelled Bimatoprost (B386800). Bimatoprost is an antiglaucoma agent. Bimatoprost is an synthetic prostamide; structurally related to prostaglandin F2α.<br>References Brandt, J.D., et al.: Ophthalmology, 108, 1023 (2001), Woodward, D.F., et al.: J. Pharmacol. Exp. Ther., 305, 772 (2003), Quinones, R., et al.: J. Ocul. Pharmacol. Ther., 20, 115 (2004),<br></p>Formula:C25H32D5NO4Colore e forma:NeatPeso molecolare:420.63'-Hydroxy-4'-methoxydiclofenac
CAS:Prodotto controllato<p>Applications 3'-Hydroxy-4'-methoxydiclofenac is a derivative of Diclofenac (Sodium Salt: D436450). Diclofenac is the first non-steroidal anti-inflammatory drug (NSAID) that is derived from phenylacetic acid. Diclofenac, like other NSAIDs, primarily works by targeting the cyclo-oxygenase pathway in the arachidonic acid cascade, reducing the formation of inflammation mediators in the body.<br>References Ku, E., et al.: Am. J. Med., 80, 18 (1986); Simmons, D., et al.: Proc. Nat. Acad. Sci., 96, 3275 (1999); Small, R.: Clin. Pharm., 8, 545 (1989)<br></p>Formula:C15H13Cl2NO4Colore e forma:NeatPeso molecolare:342.171-(4-(Trifluoromethoxy)phenyl)-2-thiourea
CAS:Prodotto controllatoFormula:C8H7F3N2OSColore e forma:NeatPeso molecolare:236.21Brinzolamide Hydrochloride
CAS:Prodotto controllato<p>Applications Carbonic anhydrase inhibitor. Antiglaucoma agent.<br>References Silver, L.H., et al.: Am. J. Ophthalmol., 126, 400 (1998), Davies, N., et al.: Clin. Exp. Pharmacol. Physiol., 27, 558 (2000), Stave, J., et al.: Ophthalmologe, 99, 276 (2002),<br></p>Formula:C12H21N3O5S3·ClHColore e forma:NeatPeso molecolare:419.97Ref: ST-EA-CP-L15036
10mgPrezzo su richiesta25mgPrezzo su richiesta50mgPrezzo su richiesta100mgPrezzo su richiestaIvermectin-d2
CAS:Prodotto controllato<p>Applications Isotope labelled Ivermectin, is the labeled analogue of Ivermectin (I940800), which is a semi-synthetic derivative of Abamectin; consists of a mixture of not less than 80% component B1a and not more than 20% component B1b. Antihelmintic (Onchocerca). An invitro inhibitor of SARS-CoV-2/ Covid-19.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Chabala, J.C., et al.: J. Med. Chem., 23, 1134 (1980), Campbell, W.C., et al.: Science, 221, 823 (1983), Bennett, J.L., et al.: Parasitol. Today, 4, 226 (1988), Plaisier, A.P., et al.: J. Infect. Dis., 172, 204 (1995), ; Caly, L., et al.: Antivir. Res., 178<br></p>Formula:C48H72D2O14Colore e forma:NeatPeso molecolare:877.11N-(R)-Glycidyl Phthalimide
CAS:Prodotto controllato<p>Applications Reagent used for the simultaneous preparation of amino alcohol solvating agents as well as preparation of orally available anticoagulants.<br>References Roehrig, S. et al: J. Med. Chem., 48, 5900 (2005); Bozkurt, S. et al: Tetra: Asymm., 22, 541 (2011);<br></p>Formula:C11H9NO3Colore e forma:NeatPeso molecolare:203.19Methylamine (40% w/w in H2O)
CAS:Prodotto controllatoFormula:CH5NColore e forma:Colourless LiquidPeso molecolare:31.06Ref: ST-EA-CP-C31006
10mgPrezzo su richiesta25mgPrezzo su richiesta50mgPrezzo su richiesta100mgPrezzo su richiestaRef: ST-EA-CP-G3094
10mgPrezzo su richiesta25mgPrezzo su richiesta50mgPrezzo su richiesta100mgPrezzo su richiestaRef: ST-EA-CP-E53078
10mgPrezzo su richiesta25mgPrezzo su richiesta50mgPrezzo su richiesta100mgPrezzo su richiestaRef: ST-EA-CP-C23070
10mgPrezzo su richiesta25mgPrezzo su richiesta50mgPrezzo su richiesta100mgPrezzo su richiestaDiclofenac Dimer Impurity
CAS:<p>Applications Diclofenac Dimer Impurity, is an metabolite of Diclofenac (D436450), which is nonsteroidal anti-inflammatory compound acting as decycloxygenase (COX) inhibitor.<br>References Kenny, J. R., et al.: J. Med. Chem., 47, 2816 (2004), Sasaki, A., et al.: J. Pharmacol. Sci., 108, 266 (2008), Dalvie, D., et al.: Chem. Res. Toxicol., 22, 357 (2009),<br></p>Formula:C28H20Cl4N2O4Colore e forma:Light Orange Colour To RedPeso molecolare:590.28Diethyl Phthalate
CAS:<p>Applications A phthalate metabolite with genotoxic effect. This compound is a contaminant of emerging concern (CECs).<br>References Reyes, F., et al.: J. Clin. Endocrinol. Metab., 37, 74 (1973), Engel, S., et al.: Neurotoxicology, 30, 522 (2009),<br></p>Formula:C12H14O4Colore e forma:ColourlessPeso molecolare:222.24Ref: ST-EA-CP-S43034
10mgPrezzo su richiesta25mgPrezzo su richiesta50mgPrezzo su richiesta100mgPrezzo su richiestaRef: ST-EA-CP-G6033
10mgPrezzo su richiesta25mgPrezzo su richiesta50mgPrezzo su richiesta100mgPrezzo su richiestaRef: ST-EA-CP-E10014
10mgPrezzo su richiesta25mgPrezzo su richiesta50mgPrezzo su richiesta100mgPrezzo su richiestaRef: ST-EA-CP-S3237
10mgPrezzo su richiesta25mgPrezzo su richiesta50mgPrezzo su richiesta100mgPrezzo su richiestaRef: ST-EA-CP-M69016
10mgPrezzo su richiesta25mgPrezzo su richiesta50mgPrezzo su richiesta100mgPrezzo su richiesta4’-Hydroxy Diclofenac-D4
CAS:Prodotto controllatoFormula:C142H4H7Cl2NO3Colore e forma:NeatPeso molecolare:316.17(5E)-Bimatoprost
CAS:<p>Applications The trans-isomer used in the improved process for the production and purification of Bimatoprost (B386800).<br></p>Formula:C25H37NO4Colore e forma:NeatPeso molecolare:415.56Argatroban
CAS:<p>Argatroban (MCI-9038), a specific thrombin inhibitor, which is a non-heparin anticoagulant, prevents the formation of thrombi.</p>Formula:C23H36N6O5SPurezza:99.77% - >99.99%Colore e forma:White To Off-White Crystalline SolidPeso molecolare:508.63trans-Latanoprost
CAS:<p>Impurity Latanoprost USP Related Compound A<br>Stability Temperature Sensitive<br>Applications Prostaglandin analog; prodrug of active acid metabolite. It is a synthetic derivative of the natural prostaglandin PGF2α, used as an anti-glaucoma agent that is effective in various types of glaucoma and ocular hypertension. Latanoprost USP Related Compound A.<br>References Resul, B., et al.: J. Med. Chem., 36, 2242 (1993), Toris, C., et al.: Ophthalmology, 100, 1297 (1993), Holmstrom, S., et al.: Curr. Med. Res. Op., 21, 1875 (2005),<br></p>Formula:C26H40O5Colore e forma:ColourlessPeso molecolare:432.591-(4-Methoxyphenyl)-7-oxo-6-[4-(2-oxopiperidin-1-yl)phenyl]-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylic Acid
CAS:Formula:C25H24N4O5Colore e forma:Light Orange ColourPeso molecolare:460.48Ramiprilat
CAS:Prodotto controllato<p>Impurity Ramipril EP Impurity E<br>Stability Hygroscopic<br>Applications Ramiprilat (Ramipril EP Impurity E) is a metabolite of Ramipril (R111000), and acts as an ACE inhibitor (1). Reduces the need for dialysis among patients previously on angiotensin-converting-enzyme inhibitors (2). Ramipril is used in stroke prevention. (3)<br>References 1. Teetz, V. et al.: Arzneimittelforschung. 1984;34(10B):1399-401.2. Ruggenenti, P. et al.: Lancet. 1998 Oct 17;352(9136):1252-6.3. Badrinath, P. et al.; BMJ. 2002 Aug 24; 325(7361): 439.<br></p>Formula:C21H28N2O5Colore e forma:Light YellowPeso molecolare:388.46ent-Rivaroxaban
CAS:<p>Applications ent-Rivaroxaban is the R-isomer of Rivaroxaban (R538000), which is a novel antithrombotic agent. A highly potent and selective, direct FXa inhibitor.<br>References Ansell, J., et al.: Drugs, 64, 1 (2004), Eriksson, B., et al.: J. Thromb. Haemost., 3, 103 (2005), Kubitza, D., et al.: Clin. Pharmacol. Ther., 78, 412 (2005),<br></p>Formula:C19H18ClN3O5SColore e forma:White To Off-WhitePeso molecolare:435.88Scopine Methobromide
CAS:<p>Impurity Tiotropium EP Impurity G<br>Applications Scopine Methobromide (Tiotropium EP Impurity G) is an impurity of Tiotropium (T444850), an muscarinic receptor antagonist and bronchodilator.<br>References Haddad, E.-B., et al.: Mol. Pharmacol., 45, 899 (1994); Donohue, J. F., et al.: Chest, 122, 47 (2002); Profita, M., et al.: Allergy, 60, 1361 (2005); Dusser, D., et al.: Eur. Respir. J., 27, 547 (2006)<br></p>Formula:C9H16NO2·BrColore e forma:Off-WhitePeso molecolare:250.13(4-Carboxy-3-ethoxy)phenyl Acetic Acid
CAS:Prodotto controllato<p>Impurity Repaglinide EP Impurity A<br>Applications (4-Carboxy-3-ethoxy)phenyl Acetic Acid (Repaglinide EP Impurity A) is a Repaglinide impurity.<br>References Owens, D., et al.: Eur. J. Clin. Invest., 29, 30 (1999), Wolffenbuttel, B., et al.: Neth. J. Med., 55, 229 (1999),<br></p>Formula:C11H12O5Colore e forma:NeatPeso molecolare:224.21Bis-[Des(5-Chloro-2-carboxythienyl)] Rivaroxaban Phthalamide
CAS:Prodotto controllatoFormula:C36H36N6O10Colore e forma:NeatPeso molecolare:712.712-[2-[[4-[(5S)-5-[[[(5-Chloro-2-thienyl)carbonyl]amino]methyl]-2-oxo-3-oxazolidinyl]phenyl]amino]ethoxy]-acetic Acid Hydrochloride
CAS:Prodotto controllato<p>Stability Hygroscopic<br>Applications 2-[2-[[4-[(5S)-5-[[[(5-chloro-2-thienyl)carbonyl]amino]methyl]-2-oxo-3-oxazolidinyl]phenyl]amino]ethoxy]-acetic Acid Hydrochloride is a metabolite of Rivaroxaban (R538000) which is a novel antithrombotic agent. Rivaroxaban is also a highly potent and selective, direct FXa inhibitor.<br>References Ansell, J., et al.: Drugs, 64, 1 (2004), Eriksson, B., et al.: J. Thromb. Haemost., 3, 103 (2005), Kubitza, D., et al.: Clin. Pharmacol. Ther., 78, 412 (2005)<br></p>Formula:C19H20ClN3O6S·HClColore e forma:White Light RedPeso molecolare:453.9036463-(Formylamino)-1H-pyrazole-4-carboxamide
CAS:Prodotto controllato<p>Impurity Allopurinol EP Impurity B / Allopurinol USP Related Compound B<br>Stability Hygroscopic<br>Applications 3-(Formylamino)-1H-pyrazole-4-carboxamide (Allopurinol EP Impurity B) is an impurity of Allopurinol (A547300) with inhibitory effects on human hypoxanthine phosphoribosyltransferase.<br>References Krenitzky, T.A. et al.: J. Biol. Chem., 244, 1263 (1969);<br></p>Formula:C5H6N4O2Colore e forma:White To Off-WhitePeso molecolare:154.1272-Oxo-ivabradine Hydrochloride
CAS:Prodotto controllatoFormula:C27H34N2O6·ClHColore e forma:NeatPeso molecolare:519.034-[4-[(5S)-5-Phthalimidomethyl-2-oxo-3-oxazolidinyl]phenyl]-3-morpholinone
CAS:Prodotto controllatoFormula:C22H19N3O6Colore e forma:NeatPeso molecolare:421.404-Chlorobenzal Chloride
CAS:<p>Applications 4-Chlorobenzal Chloride is an impurity that is formed in the synthesis of Benoxaprofen (B165300); a non-steroidal anti-inflammatory ophthalmic agent.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Cockerill, A.F., et al.: J. Chromatogr., 129, 339 (1976); Mathur, K., et al.: Bioorg. Med. Chem., 11, 1915 (2003); Zhao, M., et al.: Bioorg. Med. Chem., 15, 2815 (2007); Roy, K., et al.: Eur. J. Med. Chem., 44, 2913 (2009)<br></p>Formula:C7H5Cl3Colore e forma:NeatPeso molecolare:195.47Diclofenac Acyl-β-D-glucuronide Allyl Ester
CAS:Prodotto controllato<p>Applications An intermediate for the synthesis of Diclofenac’s glucuronide metaoblite.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Kenny, J.R., et al.: J. Med. Chem., 47, 2816 (2004),<br></p>Formula:C23H23Cl2NO8Colore e forma:NeatPeso molecolare:512.34N-Carbamoyl Oxcarbazepine
Prodotto controllato<p>Applications N-Carbamoyl Oxcarbazepine is an impurity of Oxcarbazepine (O869250), a metabolite of Eslicarbazepine acetate, (BIA 2-093), a novel central nervous system drug. A keto derivative of Carbamazepine. Used as an anticonvulsant.<br>References Dam., M., et al.: Epilepsy Res., 3, 70 (1989), Beydoun, A., et al.: Expert Opin. Pharmacother., 3, 59 (2001),<br></p>Formula:C16H13N3O3Colore e forma:NeatPeso molecolare:295.29O-Desmethyl Brinzolamide
CAS:Prodotto controllato<p>Impurity Brinzolamide O-Desmethyl Impurity<br>Applications O-Desmethyl Brinzolamide is a derivative of Brinzolamide (B677601), a carbonic anhydrase inhibitor that is used as an ocular topical treatment for patients experiencing intraocular pressure. Brinzolamide reduces pressure by reducing the rate of aqueous humour formation.<br>References Cvetkovic, R. & Perry, C.: Drugs & Aging, 20, 919 (2003); Ermis, S., et al.: Eye, 19, 303 (2005); Silver, L., et al.: Surv. Ophthalmol., 44, S147 (2000)<br></p>Formula:C11H19N3O5S3Colore e forma:NeatPeso molecolare:369.4807Diclofenac Methyl Ester
CAS:Prodotto controllato<p>Impurity Aceclofenac EP Impurity B<br>Applications Diclofenac Methyl Ester is the methyl ester analogue of Diclofenac (D436450), a known nonsteroidal anti-inflammatory compound and cyclooxygenase (COX) inhibitor. Aceclofenac EP Impurity B<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Dannhardt, G., et al.: Eur. J. Med. Chem., 36, 109 (2001), Sorbera, L., et al.: Drug Future, 26, 133 (2001), Sorbera, L., et al.: Drug Future, 26, 133 (2001),<br></p>Formula:C15H13Cl2NO2Colore e forma:NeatPeso molecolare:310.18Diclofenac Ethyl Ester
CAS:Prodotto controllato<p>Impurity Aceclofenac EP Impurity C<br>Applications A Diclofenac derivative as anti-inflammatory and analgesic agent. Aceclofenac EP Impurity C<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Dannhardt, G., et al.: Eur. J. Med. Chem., 36, 109 (2001), Sorbera, L., et al.: Drug Future, 26, 133 (2001), Sorbera, L., et al.: Drug Future, 26, 133 (2001),<br></p>Formula:C16H15Cl2NO2Colore e forma:White To Light BrownPeso molecolare:324.203-Morpholino-1-(4-(2-oxopiperidin-1-yl)phenyl)-5,6-dihydropyridin-2(1H)-one
CAS:Prodotto controllato<p>Applications 3-Morpholino-1-(4-(2-oxopiperidin-1-yl)phenyl)-5,6-dihydropyridin-2(1H)-one (cas# 545445-44-1) is a useful research chemical.<br></p>Formula:C20H25O3N3Colore e forma:BeigePeso molecolare:355.43Ramipril Methyl Ester(>85%)
CAS:<p>Applications Ramipril Methyl Ester is an impurity of Ramipril (R111000). Ramipril Impurity A.<br>References Eckert, H., et al.: Arzneim.-Forsch./Drug Res., 35, 1251 (1985), Aboul-Enein, H., et al.: Anal. Lett., 24, 2217 (1991), Bonazzi, D., et al.: J. Pharm. Biomed. Anal., 16, 431 (1997),<br></p>Formula:C22H30N2O5Purezza:>85%Colore e forma:NeatPeso molecolare:402.48(5-Amino-2-butyl-3-benzofuranyl)[4-[3-(dibutylamino)propoxy]phenyl]methanone
CAS:Prodotto controllato<p>Applications (5-Amino-2-butyl-3-benzofuranyl)[4-[3-(dibutylamino)propoxy]phenyl]methanone is an intermediate used in the synthesis of dronedarone hydrochloride (I), a class III antiarrhythmia drug for the prevention of cardiac arrhythmias such as atrial fibrillation.<br>References Mali, A. C., et al.: Org. Proc. Res. Dev., 17, 863 (2013)<br></p>Formula:C30H42N2O3Colore e forma:NeatPeso molecolare:478.67Cyclosporin D
CAS:Prodotto controllato<p>Applications A group of nonpolar cyclic oligopeptides with immunosupppressant activity.<br>References van Wartburg, A., et al.: Prog. Med. Chem., 25, 1 (1988), Jorgensen, K.A., et al.: Scand. J. Imunol., 57, 93 (2003), Vollenbroeker, et al.: Transplant. Proc., 37, 1741 (2005),<br></p>Formula:C63H113N11O12Colore e forma:Off-WhitePeso molecolare:1216.644a-Hydroxy Ivermectin
CAS:Prodotto controllato<p>Stability Hygroscopic<br>Applications 4a-Hydroxy Ivermectin is an impurity of Ivermectin (I940800), an antiparasitic drug that is active against a wide variety of nematode and arthropod parasites and is used to treat scabies and lice in humans. An invitro inhibitor of SARS-CoV-2/ Covid-19.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Campbell, W., et al.: Science, 221, 823 (1983); Glaziou, P., et al.: Trop. Med. Parasitol., 45, 253 (1994); Meinking, T., et al.: New Engl. J. Med., 333, 26 (1995); Caly, L., et al.: Antivir. Res., 178<br></p>Formula:C48H74O15Colore e forma:NeatPeso molecolare:891.09Dextrosimendan
CAS:Prodotto controllato<p>Applications Dextrosimendan is an isomer and impurity of Levosimendan (L378000), a bioactive enantiomer of Simendan (S466000). Levosimendan is a positive inotropic agent with vasodilating activity.<br>References Sandell, E.-P., et al.: J. Cardiovasc. Pharmacol., 26, S57 (1995); Pagel, P.S., et al.: Cardiovasc. Drug Rev., 14, 286 (1996)<br></p>Formula:C14H12N6OColore e forma:Yellow To Dark YellowPeso molecolare:280.282-Chloro-N-(2,6-dichlorophenyl)-N-phenylacetamide
CAS:Prodotto controllato<p>Impurity Diclofenac Impurity<br>Applications 2-Chloro-N-(2,6-dichlorophenyl)-N-phenylacetamide is used as a reactant in the preparation of 1-(2,6-dichlorophenyl)-3-methylene-1,3-dihydro-indol-2-one derivatives with in vitro cytotoxic activity on SW620 colon cancer cell lines.<br>References Virsodia, V., et. al.: Eur. J. Med. Chem., 44, 1355 (2009)<br></p>Formula:C14H10Cl3NOColore e forma:WhitePeso molecolare:314.59Argatroban Ethyl Ester
Prodotto controllatoFormula:C25H40N6O5SColore e forma:NeatPeso molecolare:536.687Bimatoprost 13,14-Epoxide
<p>Applications Bimatoprost 13,14-Epoxide is the impurity of Bimatoprost (B386800), which is an antiglaucoma agent. Bimatoprost is an synthetic prostamide; structurally related to prostaglandin F2α.<br>References Brandt, J.D., et al.: Ophthalmology, 108, 1023 (2001), Woodward, D.F., et al.: J. Pharmacol. Exp. Ther., 305, 772 (2003), Quinones, R., et al.: J. Ocul. Pharmacol. Ther., 20, 115 (2004)<br></p>Formula:C25H37NO5Colore e forma:ColourlessPeso molecolare:431.56(E/Z)-3-[(2-Cyano-3-ethoxy-3-oxo-1-propenyl)amino]-1H-Pyrazole-4-carboxylic Acid Ethyl Ester
CAS:<p>Applications Impurity of Allopurinol (A547300), an xanthine oxidase inhibitor used in treatment of hyperuricemia and chronic gout. Antiurolithic.<br>References Benezra, S.A., et al.: Anal. Profiles Drug Subs., 7, 1, (1978), Dalbeth, N., et al.: Rheumatology, 44, 1090 (2005), Dinarello, C., et al.: J. Exp. Med., 201, 1355 (2005),<br></p>Formula:C12H14N4O4Colore e forma:NeatPeso molecolare:278.27Ivermectin B1b
CAS:Prodotto controllatoFormula:C47H72O14Colore e forma:Off WhitePeso molecolare:861.066N-Nitroso Propafenone (2,2,3,3,3-Propyl-D5)
Prodotto controllatoFormula:C21D5H21N2O4Colore e forma:NeatPeso molecolare:375.473Ethyl 6-(4-Aminophenyl)-1-(4-methoxyphenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylate
CAS:Prodotto controllato<p>Applications Ethyl 6-(4-Aminophenyl)-1-(4-methoxyphenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylate is an impurity of Apixaban (A726700), A potent, direct, selective, and orally active inhibitor of coagulation factor Xa. It is a potential new oral coagulant that may be useful prevention of venous thromboembolism in total hip, knee replacement orthopedic surgery and stroke in treatment of patient with venous thromboembolic disorder or with atrial fibrillation.<br>References Nevuluri, N. et al.: Monat. fuer Chem., 148, 1477 (2017);<br></p>Formula:C22H22N4O4Colore e forma:NeatPeso molecolare:406.43Levosimendan Cyanoacetamide Hydrazone Impurity
CAS:Prodotto controllato<p>Applications Levosimendan Cyanoacetamide Hydrazone Impurity is an impurity of Levosimendan (L378000) which is a bioactive enantiomer of racemate, Simendan. It is a positive inotropic agent with vasodilating activity and also cardiotonic.<br>References Sandell, E.-P., et al.: J. Cardiovasc. Pharmacol., 26, S57 (1995); Pagel, P.S., et al.: Cardiovasc. Drug Rev., 14, 286 (1996)<br></p>Formula:C14H14N6O2Colore e forma:Off-White To Dark OrangePeso molecolare:298.3N-Mesyldronedarone
CAS:Prodotto controllato<p>Applications N-Mesyldronedarone is an impurity of Dronedarone (D679445, HCl); a drug used for the treatment of atrial fibrillation and atrial flutter in patients who have suffered cardiac arrhythmias.<br>References Singh, B., et al.: J. Cardiovas. Pharmacol., 52, 300 (2008); Hoy, S., et al.: Drugs, 69, 1647 (2009); Hohnloser, S., et al.: New Eng. J. Med., 360, 668 (2009); Mahender, M., et al.: Org. Process Res. Dev., 18, 157 (2014)<br></p>Formula:C32H46N2O7S2Colore e forma:NeatPeso molecolare:634.854-(4-Nitrophenyl)-3-morpholinone
CAS:Prodotto controllatoFormula:C10H10N2O4Colore e forma:NeatPeso molecolare:222.20Depropylamino Chloro Propafenone
CAS:<p>Impurity Propafenone EP Impurity E; Propafenone BP Impurity E; Propafenone USP Impurity E<br>Applications Depropylamino Chloro Propafenone (Propafenone EP Impurity E; Propafenone BP Impurity E; Propafenone USP Impurity E) is an impurity of Propafenone (D288655).<br>References Hollmann, M., et al.: Arzneim.-Forsch., 33, 763 (1983); Bryson, H. M., et al.:Drugs, 45, 85 (1993);<br></p>Formula:C18H19ClO3Colore e forma:NeatPeso molecolare:318.79L-(2S,3aS,7aS)-Octahydroindole-2-carboxylic Acid
CAS:Formula:C9H15NO2Colore e forma:White To Off-WhitePeso molecolare:169.22AR-C133913XX
CAS:Prodotto controllato<p>Stability Hygroscopic<br>Applications AR-C133913XX is an metabolte of Ticagrelor (T437700) which is the first reversible oral P2Y12 receptor antagonist, provides faster, greater, and more consistent ADP-receptor inhibition than Clopidogrel. Ticagrelor is used in the treatment of acute coronary syndromes (ACS).<br>References Matetzky, S., et al.: Circulation, 109, 3171 (2004); Bassand, J., et al.: Eur. Heart J., 28, 1598 (2007); Jakubowski, J., et al.: Cardiovasc. Drug Rev., 25, 357 (2007)<br></p>Formula:C14H22N6O4SColore e forma:NeatPeso molecolare:370.43(3aR,4S,6R,6aS)-6-Aminotetrahydro-2,2-dimethyl-4H-cyclopenta-1,3-dioxol-4-ol
CAS:<p>Stability Hygroscopic<br>Applications (3aR,4S,6R,6aS)-6-Aminotetrahydro-2,2-dimethyl-4H-cyclopenta-1,3-dioxol-4-ol was used to preapare AZD6140 as an orally active reversible P2Y12 receptor antagonist for prevention of thrombosis.<br>References Zhang, H., et al.: Bioorg. Med. Chem. Lett., 22, 3598 (2012);<br></p>Formula:C8H15NO3Colore e forma:NeatPeso molecolare:173.21Methyl 2-[3-Cyano-4-(2-methylpropoxy)phenyl]-4-methylthiazole-5-carboxylate
CAS:Prodotto controllatoFormula:C17H18N2O3SColore e forma:NeatPeso molecolare:330.48-Chlorocarbazole-1-acetic Acid
CAS:Prodotto controllatoFormula:C14H10ClNO2Colore e forma:NeatPeso molecolare:259.69
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