Acidi Grassi e Derivati Lipidici

<p>Applications Intermediate for the synthesis of Tryptophan derivatives.<br>References Deveau, A., et al.: Bioorg. Med. Chem. Lett., 18, 3522 (2008),<br></p>

<p>Applications Orlistat isomer. Used in the asymmetric synthesis of Orlistat (O686500).<br>References Barbier, P., et al.: Helv. Chimica Acta, 70, 196 (1987),<br></p>

<p>Applications Dichlorodenafil is an unapproved Sildenafil (S435001) functions by inhibiting the phosphodiesterase type 5 enzyme (PDE-5).<br>References Kim, J.Y., et al.: Chem. Pharm. Bull., 61, 572 (2013)<br></p>

<p>Applications An intermediate in the synthesis of Tadalafil (T004500), which is used for the treatment of erectile dysfunction. A phosphodiesterase 5 inhibitor.<br>References Carrier, S., et al.: Can. J. Urol., 10(1), 12 (2003),<br></p>

<p>Applications Salicylic Acid Acyl-β-D-glucuronide is a metabolite of Salicylic Acid (S088125), an impurity of Acetylsalicylic Acid (A187780). Acetylsalicylic Acid Impurity B.<br>References Walter, M., et al.: Eur. J. Biochem., 1996, 239, 281 (1996); Liu, J. et al.: J. Pharm. Exp. Ther., 278, 277 (1996); Bantignies, B., et al.: Plant Mol. Biol., 42, 871 (2000); Bais, H., et al.: J. Biol. Chem., 278, 32413 (2003); Finkler, C., et al.: Genetica, 124, 117 (2005);<br></p>

<p>Applications Labelled Chenodiol (Chenodeoxycholic acid). A major bile acid in many vertebrates, occurring as the N-glycine and/or N-taurine conjugate. With other bile acids, forms mixed micelles with lecithin in bile which solubilize cholesterol and thus facilitates its excretion. Fcilitates fat absorption in the small intestine by micellar solubilization of fatty acids and monoglycerides. Anticholelithogenic. Epimeric with Ursodiol.<br>References Danzinger, et al.: N. Engl. J. Med., 286, 1 (1972), Iser, J.H., et al.: Drugs, 21, 90 (1981), Tint, G.S., et al.: Gastroenterology, 91, 1007 (1986),<br></p>

<p>Applications 2-Nonenedioic Acid is an impurity of Azelaic acid (A808140) which is an antiacne agent.<br>References Bladon, P.T., et al.: Br. J. Dermatol., 114, 493 (1986)<br></p>

<p>Applications Labelled Ezetimibe (E975000), an antihyperlipoproteinemic. A Cholesterol absorption inhibitor.<br>References van Heek, M., at al.: J. Pharmacol. Exp. Ther., 283, 157 (1997), van Heek, M., at al.: Brit. J. Pharmacol., 129, 1748 (2000)<br></p>

<p>Stability Hygroscopic<br>Applications Glycochenodeoxycholic Acid Sodium Salt is a bile salt formed in the liver from chenodeoxycholate and glycine. It acts as a detergent to solubilize fats for absorption and is itself absorbed. It is a cholagogue and choleretic.<br>References Ollila, F., et al.: Langmuir, 17, 7107 (2001), Uekama, K., et al.: Chem. Pharm. Bull., 52, 900 (2004), Tongiani, S., et al.: J. Pharm. Sci., 94, 2380 (2005),<br></p>