Peptidi

Custom research peptide; min purity 95%.

Custom research peptide; min purity 95%.

Custom research peptide; min purity 95%.

Custom research peptide; min purity 95%.

Custom research peptide; min purity 95%.

Custom research peptide; min purity 95%.

Custom research peptide; min purity 95%.

Custom research peptide; min purity 95%.

TentaGel® S AC Resin is a building block that is used as a synthetic tool to make peptides. TentaGel® S AC Resin is composed of styrene, acrylates, and divinylbenzene, which are all monomers. TentaGel® S AC Resin is used for the synthesis of peptides to be used in various experiments such as proteomics and cell biology.

HBB MS Calibrator is a research tool that is used to calibrate mass spectrometry. It is an activator of Ligand and Receptor, which are proteins that play a role in cell biology. HBB MS Calibrator binds to ion channels and inhibits the opening of these channels. This leads to a decrease in the flow of ions through the channel, which can affect a number of cellular processes. HBB MS Calibrator also has pharmacological properties that are used for drug discovery and peptide production.

Leptin is a protein hormone that is produced by fat cells. Leptin regulates appetite and energy use, and it has been shown to be involved in the regulation of body weight. Leptin binds to receptors on the surface of cells, which activates signaling pathways inside the cell. This receptor can be activated by other ligands such as ghrelin, adiponectin, and insulin. Leptin also inhibits ion channels in neurons, resulting in an increase in potassium conductance.

CIF1 is a protein that in humans is encoded by the CIF1 gene. It belongs to the family of ion channels and ligand-gated ion channels. The channel is activated by acetylcholine, a neurotransmitter, and mediates fast synaptic transmission at neuromuscular junctions. CIF1 has been shown to bind to the nicotinic acetylcholine receptor (nAChR) subunit alpha-4/beta-2. This binding leads to inhibition of nAChR function, which may be useful for treatments of conditions such as Parkinson's disease or Alzheimer's disease.

Please enquire for more information about Fmoc-Trp-Rink-Amide MBHA Resin including the price, delivery time and more detailed product information at the technical inquiry form on this page

m-dPEG®12-Amido-dPEG®12-TFP Ester is a PEG compound with two different functional groups (also known as heterobifunctional). Unlike homobifunctional PEG compounds (same functional group on both ends), this type of compounds are more versatile as have two different anchor points. m-dPEG®12-Amido-dPEG®12-TFP Ester is used as a linker and spacer to add a PEG moiety, via pegylation (a bioconjugation technique) to proteins, peptides, oligonucleotides, small molecules and nanoparticles.

TentaGel is a gelatinous resin, an important support for solid phase synthesis. TentaGel resins are constructed with a backbone of low crosslinked polystyrene grafted with polyoxyethylene (polyethylene glycol) as shown below. The typical chain length of POE (n) is approximately 68 ethylene oxide units or an average MW of 3000. This long chain creates a spacer that effectively separates the reactive site (X) from the crosslinked backbone matrix. The TentaGel S base resins are available with several different derivative choices. The typical capacity range for our TentaGel base resins is 0.2-0.3 meq/g.
Application: (90 µm)
Substitution Functional Group:-CH2-CH2-SH

Mannose-binding lectin 2 (MBL2) is a protein that is encoded by the MBL2 gene. It is an activator of the lectin complement pathway, which plays an important role in innate immunity. MBL2 binds to mannose-rich oligosaccharides and activates the lectin complement pathway. This protein also interacts with ion channels, cell surface receptors and other proteins. The recombinant human MBL2 has been expressed in E. coli. The purified protein is supplied at >95% purity and has a CAS number of 80613-62-8.

Anti-EGFR (Epidermal Growth Factor Receptor) is a monoclonal antibody that binds to the epidermal growth factor receptor (EGFR). The EGFR is a transmembrane tyrosine kinase receptor that plays an important role in cell proliferation, differentiation, and survival. Anti-EGFR can be used as a research tool for studying protein interactions, such as the interaction of peptides with receptors or ligands. It can also be used for pharmacological studies and can be used to isolate proteins from cells. This product is available in high purity, which means it has been purified by chromatography to have less than 0.1% other proteins than the product. This product is also available in a form of an antibody conjugate, which means that it has been linked to an antibody molecule that recognizes the target antigen specifically. Anti-EGFR is available in CAS No., which stands for Chemical Abstracts Service Number.

DOTA-tris(Acid)-Amido-dPEG®12-TFP Ester is a PEG compound with two different functional groups (also known as heterobifunctional). Unlike homobifunctional PEG compounds (same functional group on both ends), this type of compounds are more versatile as have two different anchor points. DOTA-tris(Acid)-Amido-dPEG®12-TFP Ester is used as a linker and spacer to add a PEG moiety, via pegylation (a bioconjugation technique) to proteins, peptides, oligonucleotides, small molecules and nanoparticles.

Substitution Functional Group:-NH-CO-CH2-CH2-COOHTentaGel; is a gelatinous resin, an important support for solid phase synthesis. TentaGel; resins are constructed with a backbone of low crosslinked polystyrene grafted with polyoxyethylene (polyethylene glycol) as shown below. The typical chain length of POE (n) is approximately 68 ethylene oxide units or an average MW of 3000. This long chain creates a spacer that effectively separates the reactive site (X) from the crosslinked backbone matrix. TentaGel; HL (High Load) (mean particle size 110 μm: capacity 04-06 meq/g)

Azido-dPEG®8-OH is a PEG polymer categorised as monofunctional (OH-PEG-X). Used as a linker, Aazido-dPEG®8-OH is used to attached PEG to proteins, peptides, oligonucleotides, nanoparticles and small molecules via pegylation, a bioconjugation technique.

Big Endothelin-3 (Rat, 1-41 Amide) is a precursor molecule of the Endothelin-3 (ET-3) peptide, that belongs to the large family of endothelin peptides which activate the G-protein coupled receptors ETA and ETB. However ET-3 has lower affinity for the ETA receptors compared to Endothelin-1 (ET-1) and Endothelin-2 (ET-2), whereas all three endothelins have similar affinity for ETB receptors. As ETB receptors make up around 90% of the endothelin receptors found in the cerebral cortex in humans, ET-3 can be nicknamed the ‘brain endothelin’. Also through ET-3’s activation of ETB receptors, ET-3 is involved in the development of the enteric nervous system which controls within the gut, blood flow, secretion and intestinal motility. This product has disulfide bonds between Cys1-Cys15 and Cys3-Cys11 and is available as a 0.1mg vial.

Prosaposin is a human, recombinant secretory protein that is produced by the freeze-drying of a lysosomal extract. It is used to treat cerebrospinal fluid that has been depleted of prosaposin. This protein functions as a linker and interacts with choline, glycosphingolipids, and phospholipids to form the myelin sheath in the central nervous system. Prosaposin can also be reconstituted with deionized water and aliquots containing 1 mg/mL of this protein are available for purchase.

Centromere protein B (CENP-B) is a protein that belongs to the histone H3 family. It is one of the proteins involved in regulating chromosome segregation during mitosis and meiosis. CENP-B has been shown to be involved in the activation of kinetochores, which are structures on the surface of chromosomes that attach to microtubules and help with mitotic chromosome movement. Centromere protein B can also be used as a ligand or receptor, or a tool for cell biology, immunology, and pharmacology research.

Cortistatin is a peptide that belongs to the group of activators. It is a high-purity product with an amino acid sequence identical to cortistatin (rat). Cortistatin activates ion channels, which may be due to its ability to bind to receptors and ligands. This product can be used in life science research or cell biology experiments as an inhibitor or as a tool for protein interactions. The CAS number for this product is 937031-00-0.

Rituximab is a chimeric monoclonal antibody used in the treatment of some cancers like CD20 non-Hodgkin's lymphoma and a few autoimmune conditions such as rheumatoid arthritis. However, antibody treatment can lead to generation of neutralising antibodies thus curtailing the efficacy of the therapy. CD 4+ T cells are critical to initiate antibody response so identification of epitopes within molecules using T cell assays can be a vital tool for understanding the immune response and thereby prevent induction of neutralising antibodies. Within rituximab, the variable region of the light chain (41-55) was found to have strong affinity for leukocytes in a specific binding assay, the epitope was also correlated to patients who developed neutralising antibodies. This T cell epitope within rituximab in further immune studies could help design or selection of antibodies without T cell epitopes present for low immunogenicity.

Alyerserin-2b is a C-terminally α-amidated 17 residue cationic anti-microbial peptide (AMP). Anti-microbial peptides (AMPs) are produced by the innate immune system and are expressed when the host is challenged by a pathogen. The Alyerserin family of peptides was first identified in norepinephrine-stimulated skin secretions of the midwife toad-Alytes obstetricans-(Alytidae). Alyteserin-2a, 2b and -2c show some sequence identity with bombinin H6, a peptide from the skins Bombinatoridae family of frogs.Alyteserin-2b is most potent against the Gram-positive bacteria-Staphylococcus aureus and has weak haemolytic activity against human erythrocytes.Alyteserin contain at least 50% hydrophobic amino acids. Hydrophobic residues contribute to the insertion of the peptide into the hydrophobic membrane core which results in membrane disruption and death of the pathogen. Due to their mechanism of action it is thought to be less likely for resistance to develop towards them compared to conventional antibiotics. Alyteserin-2b has a low probability of adopting a helical conformation unlike related Alyteserin-2 peptides.

Amino acids 195-209 of tubulin-associated unit (tau). This region represents a tau tryptic peptide and is part of the core of the tau protein. Tau is a phosphoprotein involved in microtubule (MT) assembly and stability as well as brain development. Tau is phosphorylated at multiple sites by several protein kinases, including cyclic-AMP-dependent protein kinases and casein kinase type-1. Tau phosphorylation causes tau to change shape, negatively regulating its ability to stimulate MT assembly. Tau is also glycosylated, and-O-glycosylation may have a role in its subcellular localisation and degradation.Malfunctioning tau protein contributes to the structural core of the paired helical filaments (PHFs), which make up neurofibrillary tangles (NFTs). NFTs are often observed in neurodegenerative disorders, such as Alzheimer disease and other tauopathies. Tau is expressed from a single gene and is alternatively spliced to yield six different isoforms in the adult central nervous system (CNS).

The cyclic AMP (cAMP) response element binding protein (CREB) is a transcription factor that regulates the transcription of several genes that mediate important cellular processes. CREB is phosphorylated by several kinases, including PKA- Akt- and CamK I, II, and IV. Phosphorylated pCREB translocates to the nucleus, where it forms homodimers or heterodimers, and recruits p300/CREB binding protein (CBP) to initiate transcription of its target genes. pCREB is an important regulator of apoptosis and is also involved in modulating several immune processes and neuronal plasticity. CREB signalling has a critical role in the formation of memories and may be dysfunctional in the brains of Alzheimer's disease (AD).Peptide is labelled with an N-terminal 5-carboxyfluorescein (5-FAM), a widely used green fluorescent tag.