Peptidi

CCL2 (Chemokine C-C Motif Ligand 2), also known as monocyte chemoattractant protein 1 (MCP1) or small inducible cytokine A2 (SCYA2), is a protein classified as a chemotactic cytokine or chemokine. CCL2 binds to the chemokine receptors CCR2 and CCR5.
CCL2 belongs to the CC chemokine family, small soluble proteins whose main function is to regulate cell trafficking and that act as molecular signals to induce cellular migration during inflammation.
Chemokines are secreted in response to signals such as proinflammatory cytokines and induce chemotaxis through the activation of G-protein-coupled receptors (GPCRs), which involves adhesion molecules and glycosaminoglycans.
CCL2 is produced by a lot of cell types (endothelial, fibroblasts, epithelial, smooth muscle, monocytic, and microglial cells which are important for antiviral immune responses and in tissue), often after induction by oxidative stress, cytokines or growth factors.
Unlike other chemokines such as RANTES, CCL2 exhibits a chemotactic activity only for monocytes, T-cells, basophils, NK cells and immature dendritic cells. CCL2 doesn’t attract and activate neutrophils or eosinophils.
But like RANTES, CCL2 has the ability to target memory T-cells, which is not the case with other chemokines.

Muscle-type nAChRs blocker

Universal Major Histocompatibility Complex (MHC) H2 I-Ab epitope for CD4+ T-cell recruitment and activation
SB-PEPTIDE offers I-Ab restricted PADRE peptide ak(Cha)VAAWTLKAAa-Ahx-C.
Pan DR-binding epitope (PADRE) is a universal synthetic peptide binding Major Histocompatibility Complex (MHC)-II receptors, of which H2 complex (mouse MHC), present on specific immune cells. 4 class II loci exist in the region I of the H2 complex gene (see image below), known as Aa & Ea loci (α encoded) and Ab & Eb loci (β encoded), that are similar to the DR, DP and DQ loci of the Human Leukocyte Antigen (HLA) complex.
I-Ab restricted PADRE peptide interacts specifically with mouse H2-I-Ab receptors that activate antigen specific CD4+ T-cells in the same way as PADRE peptide’s interaction with HLA-DR receptors. This feature places I-Ab restricted PADRE as promising adjuvant for immunotherapeutic vaccines against chronicle diseases such as infections, Alzheimer or cancer. Similarly to the original PADRE peptide, the restricted version also acts as a Toll-like receptor (TLR) agonist and was described as alternative carrier, such as KLH/BSA or OVA, for prophylaxis and therapeutic vaccines. An aminocaproic acid (Ahx) linker, attached to an additional C-terminal Cysteine, was added to the sequence to allow both the peptide and its loading to interact independently and freely with molecules exposed to them. This modification is used for the loading of antigenic determinants in solution in order to enhance the immune response against a specific antigen (AG).

FRETS-25-STD1 is a synthetic peptide that binds to and activates the TRPA1 receptor. It has been shown to inhibit the activity of the TRPA1 receptor in vitro, but has not been tested for in vivo activity. FRETS-25-STD1 competitively inhibits binding of various ligands to the TRPA1 receptor, including allyl isothiocyanate, cinnamaldehyde, and 4-hydroxybenzoic acid. FRETS-25-STD1 also inhibits activation of the TRPA1 receptor by agonists such as AITC or cinnamaldehyde.

MAGE-A3 (195-203) peptide – IMPKAGLLI – Epitope of Melanoma Antigen Gene A3

Biotin-SARS-CoV-2 Spike RBD 371-394 peptide is the biotinylated version of SARS-CoV-2 Spike RBD 371-394 peptide. SARS-CoV-2 Spike RBD 371-394 peptide is an epitope of interest of the SARS-CoV-2 Spike S glycoprotein Receptor-Binding Domain (RBD). Biotin-SARS-CoV-2 Spike RBD 371-394 peptide is useful for vaccine development and for structure-activity relationship studies
SARS-CoV-2 Spike (S) glycoprotein
Spike (S) glycoprotein corresponds to one of the leading targets for COVID-19 disease. Present on the surface of Sars-CoV-2 virus, Spike S protein is a class I fusion protein that allows the virus to enter host cells.
With a 1 273 aa length, Spike protein has 2 subunits : S1 contains the receptor-binding domain RBD and S2 induces the fusion of the viral envelop with the cellular membrane.
SARS-CoV-2 Spike RBD:
The receptor-binding domain in SARS-CoV-2 Spike protein allows binding to the Angiotensin-Converting Enzyme receptor 2 (ACE2 receptor) which mediates the viral entry.

Voltage-gated sodium channels blocker

MAL-dPEG®4-(m-dPEG®4)3 is a PEG compound with two different functional groups (also known as heterobifunctional). Unlike homobifunctional PEG compounds (same functional group on both ends), this type of compounds are more versatile as have two different anchor points. MAL-dPEG®4-(m-dPEG®4)3 is used as a linker and spacer to add a PEG moiety, via pegylation (a bioconjugation technique) to proteins, peptides, oligonucleotides, small molecules and nanoparticles.

Amyloid β (42- 1) SCR is a peptide that inhibits the interaction of amyloid β with its receptor, which may be useful for research purposes. Amyloid β (42- 1) SCR is an inhibitor that prevents the binding of amyloid β to its receptors. This peptide is a high purity product and has been shown to be effective in inhibiting the interaction between amyloid beta and its receptor.

Biotin-SARS-CoV-2 Spike RBD 319-335 peptide is the biotinylated version of SARS-CoV-2 Spike RBD 319-335 peptide. SARS-CoV-2 Spike RBD 319-335 peptide is an epitope of interest of the SARS-CoV-2 Spike S glycoprotein Receptor-Binding Domain (RBD). Biotin-SARS-CoV-2 Spike RBD 319-335 peptide is useful for vaccine development and for structure-activity relationship studies
SARS-CoV-2 Spike (S) glycoprotein
Spike (S) glycoprotein corresponds to one of the leading targets for COVID-19 disease. Present on the surface of Sars-CoV-2 virus, Spike S protein is a class I fusion protein that allows the virus to enter host cells.
With a 1 273 aa length, Spike protein has 2 subunits : S1 contains the receptor-binding domain RBD and S2 induces the fusion of the viral envelop with the cellular membrane.
SARS-CoV-2 Spike RBD:
The receptor-binding domain in SARS-CoV-2 Spike protein allows binding to the Angiotensin-Converting Enzyme receptor 2 (ACE2 receptor) which mediates the viral entry.

Clickable TAT peptide.

Angiotensin II plays an essential role in the maintenance of blood pressure and blood volume. It is a peptide hormone that causes vasoconstriction, a sensation of thirst, and stimulation of the adrenal cortex and aldosterone.
Derived from the cleavage of angiotensin I by the angiotensin converting enzyme, angiotensin II is involved in the renin-angiotensin system (RAS).
Angiotensin II is the subject of much scientific research and is already the target of many anti-hypertensive drugs (ACE inhibitors, ARBs or AT1 receptor antagonists).

SIL peptide for Adalimumab detection and quantification

The S-100ß ELISA kit is a solid phase sandwich enzyme-linked immunosorbent assay (ELISA) that detects the presence of S-100ß protein in serum, plasma, or cerebrospinal fluid. The assay employs an antibody specific for S-100ß protein and an enzyme-labeled anti-IgG antibody as a second antibody to detect bound S-100ß protein.

Blocker of Kv4.2 and Kv4.3 channels

CMV pp65 protein:
CMV pp65 (113-121) is an epitope of the main component of the enveloped subviral particle pp65 (phosphoprotein ppUL83) of Cytomegalovirus, member of herpes virus group. CMV pp65 antigens are used as target for the diagnosis of concomitant CMV end-organ disease. CMV specific cytotoxic T lymphocyte response is highly focused to pp65 in the context of HLA-A24:02.
Applications of CMV pp65 (113-121):
CMV pp65 (113-121) is used to stimulate peptide-specific CTL response and to analyze interferon γ production by flow cytometry and ELISPOT assay. CMV pp65 (113-121) contains HLA-A24 binding site and elicits CMV pp65 (113-121)-specific CTL in PBMCs which recognize pp65 expressed on CMV-infected fibroblast of HLA-A24 positive patients. CMV pp65 (113-121) might be implicated in improvement of immunotherapeutic strategies for efficient vaccine development against HCMV.

MBP (Myelin Basic Protein – UniProtKB – P04370) is a major constituent of the myelin in nerves. This protein permits the maintain of the myelin structure. MBP contains various epitopes implicated in Multiple Sclerosis.
MBP (84-97) induces EAE

Fluorescent TAT peptide.

Peptide H-PVLDLFRELLNELLEALKQKLK-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.

Peptide H-GFLSDLLK-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.

Insl3 is a protein that is localized in the ovary and human chorionic gonadotropin. It is also found in human serum. In animals, Insl3 causes fertility. In humans, it stimulates the development of the gubernaculum, which attaches to the testes. The expression of Insl3 increases during puberty and continues to be expressed throughout adulthood. Insl3 is translated from mRNA as a precursor protein with an N-terminal signal peptide sequence that directs its secretion from the cell into the extracellular space. The Insl3 precursor protein has two C-terminal domains: an internal domain and a carboxy-terminal domain. These domains are translated from separate initiation codons on one mRNA molecule. The internal domain contains sequences for translation initiation, ribosome binding sites, and translational stop codons; these sequences are not present in the carboxy-terminal domain. Insl3 can be detected by using an

Lipopolysaccharide (LPS) binding protein light tryptic peptide standard for use in proteomic studies. LPS are located on the outer membrane of gram-negative bacteria and are made up of a hydrophilic core polysaccharide, an O-antigen and a hydrophobic lipid A domain. As LPS is involved in interactions between the host and the pathogen it can be used as a biomarker giving an indication of infection.

Thymosin, beta 10 (human, rat) is a custom research peptide; min purity 95%, TFA salt. For different specs please use the Peptide Quote Tool

IL 10 rat (IL-10) is a cytokine that belongs to the family of IL-10 cytokines. IL-10 binds to the IL-10 receptor and inhibits the release of proinflammatory cytokines, including TNF-α, IL-1β, and IL-6. This cytokine has been shown to inhibit the production of reactive oxygen species by macrophages and neutrophils. The physiological role of this cytokine is not yet fully understood, but it is believed to be important for immune regulation in response to bacterial infections.

Bombesin is a small peptide that was first isolated from the skin of a frog, Bombina bombina, with homologs later found to be present in mammalian tissues, including the brain and gastrointestinal tract. It is a member of the bombesin-like peptide family, which includes several related peptides such as gastrin-releasing peptide (GRP) and neuromedin B.
Bombesin acts as a neuromodulator and regulates various physiological functions, including gastrointestinal motility and stimulation of gastrin release from G cells. It also plays a role in the regulation of cardiovascular function and neurotransmitter release. In addition, bombesin has been shown to stimulate the growth and proliferation of certain types of cancer cells, including prostate and lung cancer cells, through its interaction with bombesin receptors. It may therefore be used as a potential biomarker for certain cancers.

Peptide H-LSGR-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.

A synthetic peptide for use as a blocking control in assays to test for specificity of ABRA antibody, catalog no. 70R-9194

A synthetic peptide for use as a blocking control in assays to test for specificity of ANXA3 antibody, catalog no. 70R-1678

A synthetic peptide for use as a blocking control in assays to test for specificity of KCNQ5 antibody, catalog no. 70R-5180

A synthetic peptide for use as a blocking control in assays to test for specificity of PSG5 antibody, catalog no. 70R-5400

A synthetic peptide for use as a blocking control in assays to test for specificity of AVIL antibody, catalog no. 70R-7947

A synthetic peptide for use as a blocking control in assays to test for specificity of IRX6 antibody, catalog no. 20R-1145

A synthetic peptide for use as a blocking control in assays to test for specificity of PDPK1 antibody, catalog no. 70R-7831

A synthetic peptide for use as a blocking control in assays to test for specificity of AK1 antibody, catalog no. 70R-2397

A synthetic peptide for use as a blocking control in assays to test for specificity of TMPRSS12 antibody, catalog no. 70R-7490

A synthetic peptide for use as a blocking control in assays to test for specificity of CYP4F3 antibody, catalog no. 70R-7504

A synthetic peptide for use as a blocking control in assays to test for specificity of SDCBP antibody, catalog no. 70R-6621

A synthetic peptide for use as a blocking control in assays to test for specificity of ASB8 antibody, catalog no. 70R-5837

A synthetic peptide for use as a blocking control in assays to test for specificity of NOL4 antibody, catalog no. 70R-4720

A synthetic peptide for use as a blocking control in assays to test for specificity of BSG antibody, catalog no. 70R-9879

A synthetic peptide for use as a blocking control in assays to test for specificity of Ccbe1 antibody, catalog no. 70R-9189

A synthetic peptide for use as a blocking control in assays to test for specificity of TMC2 antibody, catalog no. 70R-6319

A synthetic peptide for use as a blocking control in assays to test for specificity of C21orf45 antibody, catalog no. 70R-3295

A synthetic peptide for use as a blocking control in assays to test for specificity of ACSL4 antibody, catalog no. 70R-7155

A synthetic peptide for use as a blocking control in assays to test for specificity of Prdm12 antibody, catalog no. 70R-9558

A synthetic peptide for use as a blocking control in assays to test for specificity of ZNF619 antibody, catalog no. 70R-8157

A synthetic peptide for use as a blocking control in assays to test for specificity of IDH1 antibody, catalog no. 70R-2495

A synthetic peptide for use as a blocking control in assays to test for specificity of FAM90A1 antibody, catalog no. 70R-4363

A synthetic peptide for use as a blocking control in assays to test for specificity of MAGED2 antibody, catalog no. 70R-9922

A synthetic peptide for use as a blocking control in assays to test for specificity of FDXR antibody, catalog no. 70R-2532

A synthetic peptide for use as a blocking control in assays to test for specificity of SSTR1 antibody, catalog no. 70R-9812

A synthetic peptide for use as a blocking control in assays to test for specificity of POLR1E antibody, catalog no. 70R-3384

A synthetic peptide for use as a blocking control in assays to test for specificity of GLIPR1L1 antibody, catalog no. 70R-4567

A synthetic peptide for use as a blocking control in assays to test for specificity of METTL5 antibody, catalog no. 70R-3352

A synthetic peptide for use as a blocking control in assays to test for specificity of PSMD8 antibody, catalog no. 70R-2345

A synthetic peptide for use as a blocking control in assays to test for specificity of MAP1LC3A antibody, catalog no. 70R-2895

A synthetic peptide for use as a blocking control in assays to test for specificity of CXCL14 antibody, catalog no. 20R-1308

A synthetic peptide for use as a blocking control in assays to test for specificity of KCNMB4 antibody, catalog no. 70R-5108

A synthetic peptide for use as a blocking control in assays to test for specificity of STK39 antibody, catalog no. 70R-1017

A synthetic peptide for use as a blocking control in assays to test for specificity of TPH2 antibody, catalog no. 70R-2011

A synthetic peptide for use as a blocking control in assays to test for specificity of EPS8L1 antibody, catalog no. 70R-1259

A synthetic peptide for use as a blocking control in assays to test for specificity of B4GALT2 antibody, catalog no. 70R-6779

A synthetic peptide for use as a blocking control in assays to test for specificity of C1orf102 antibody, catalog no. 70R-4047

A synthetic peptide for use as a blocking control in assays to test for specificity of ZNF440 antibody, catalog no. 70R-8127

A synthetic peptide for use as a blocking control in assays to test for specificity of CTDSP2 antibody, catalog no. 70R-3879

A synthetic peptide for use as a blocking control in assays to test for specificity of EBAG9 antibody, catalog no. 70R-9916

A synthetic peptide for use as a blocking control in assays to test for specificity of CASD1 antibody, catalog no. 70R-7436

A synthetic peptide for use as a blocking control in assays to test for specificity of WNT16 antibody, catalog no. 70R-1909

A synthetic peptide for use as a blocking control in assays to test for specificity of GJA1 antibody, catalog no. 70R-6088

A synthetic peptide for use as a blocking control in assays to test for specificity of 2610034B18Rik antibody, catalog no. 70R-9356

A synthetic peptide for use as a blocking control in assays to test for specificity of C2orf29 antibody, catalog no. 70R-3470

A synthetic peptide for use as a blocking control in assays to test for specificity of EXOC1 antibody, catalog no. 70R-9538

A synthetic peptide for use as a blocking control in assays to test for specificity of UNC45A antibody, catalog no. 70R-2703

A synthetic peptide for use as a blocking control in assays to test for specificity of TPX2 antibody, catalog no. 70R-5626

A synthetic peptide for use as a blocking control in assays to test for specificity of RHPN1 antibody, catalog no. 70R-2697

A synthetic peptide for use as a blocking control in assays to test for specificity of CHST6 antibody, catalog no. 70R-5371

A synthetic peptide for use as a blocking control in assays to test for specificity of NT5DC2 antibody, catalog no. 70R-4565

A synthetic peptide for use as a blocking control in assays to test for specificity of SARS antibody, catalog no. 70R-1445

A synthetic peptide for use as a blocking control in assays to test for specificity of CHST6 antibody, catalog no. 70R-5372

A synthetic peptide for use as a blocking control in assays to test for specificity of TMEM176A antibody, catalog no. 70R-8563

A synthetic peptide for use as a blocking control in assays to test for specificity of LCN8 antibody, catalog no. 70R-3225

A synthetic peptide for use as a blocking control in assays to test for specificity of PIAS2 antibody, catalog no. 70R-2646

A synthetic peptide for use as a blocking control in assays to test for specificity of VPS52 antibody, catalog no. 70R-3819

A synthetic peptide for use as a blocking control in assays to test for specificity of Fmo3 antibody, catalog no. 70R-8601

A synthetic peptide for use as a blocking control in assays to test for specificity of F10 antibody, catalog no. 70R-7485

A synthetic peptide for use as a blocking control in assays to test for specificity of PCDHAC1 antibody, catalog no. 70R-6120

A synthetic peptide for use as a blocking control in assays to test for specificity of PGBD2 antibody, catalog no. 70R-4210

A synthetic peptide for use as a blocking control in assays to test for specificity of Man2a2 antibody, catalog no. 70R-8659

A synthetic peptide for use as a blocking control in assays to test for specificity of SNAG1 antibody, catalog no. 70R-5764

A synthetic peptide for use as a blocking control in assays to test for specificity of BBS2 antibody, catalog no. 70R-9877

A synthetic peptide for use as a blocking control in assays to test for specificity of Angel1 antibody, catalog no. 70R-9314

A synthetic peptide for use as a blocking control in assays to test for specificity of CDH4 antibody, catalog no. 70R-6191

A synthetic peptide for use as a blocking control in assays to test for specificity of USP2 antibody, catalog no. 70R-9737

A synthetic peptide for use as a blocking control in assays to test for specificity of PRSS8 antibody, catalog no. 70R-4537

A synthetic peptide for use as a blocking control in assays to test for specificity of SLC13A3 antibody, catalog no. 70R-1822

A synthetic peptide for use as a blocking control in assays to test for specificity of MVK antibody, catalog no. 70R-3345

A synthetic peptide for use as a blocking control in assays to test for specificity of FAM81B antibody, catalog no. 70R-4168

A synthetic peptide for use as a blocking control in assays to test for specificity of ZNF280C antibody, catalog no. 70R-8333

A synthetic peptide for use as a blocking control in assays to test for specificity of RGS13 antibody, catalog no. 70R-1144