Peptidi
Sottocategorie di "Peptidi"
Trovati 29595 prodotti di "Peptidi"
H-SELEEQLTPVAEETR^-OH
Peptide H-SELEEQLTPVAEETR^-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.H-DGVPVIK^-OH
Peptide H-DGVPVIK^-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.H-QTISNACGTIGLIHAIANNK^-OH
Peptide H-QTISNACGTIGLIHAIANNK^-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.H-ISTLNSLTLPALR^-OH
Peptide H-ISTLNSLTLPALR^-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.PKA Substrate
Substrate peptide for adenosine 3',5'-monophosphate (cyclic AMP)-dependent protein kinase (PKA) and related kinases, for use in kinase assays. The peptide sequence is based on the cAMP-dependent protein kinase inhibitor alpha (amino acid 15-23).Protein kinase A (PKA) also known as cAMP-dependent protein kinase is a family of serine/threonine protein kinase enzymes whose activity is regulated by cyclic AMP (cAMP). PKA is involved in a plethora of roles within the cell including: regulation of glycogen, sugar and lipid metabolism and roles within adipocytes and hepatocytes, nucleus accumbens neurons, skeletal muscle, cardiac muscle and in memory formation.Purezza:Min. 95%Colore e forma:PowderPeso molecolare:1,117.6 g/molH-DANISQPETTK^-OH
Peptide H-DANISQPETTK^-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.HXB2 gag NO-82/aa325 - 339
Custom research peptide; min purity 95%. For different specs please use the Peptide Quote ToolPeso molecolare:1,554.8 g/molCaloxin 1C2
Plasma membrane calcium pumps (PMCA) play integral roles in calcium homeostasis and calcium signalling. There are four PMCA isoforms (1-4), their expression and localisation are varied amongst cell types and diseased tissue. Therefore, identification of specific inhibitors of each PMCA is underway to aid understanding of the individual roles the PMCAs play. Use of phage libraries and mutagenesis has allowed rapid screening of possible peptides. A PMCA inhibitor of importance found by screening and mutagenesis is caloxin 1C2. Caloxin 1C2 has been shown to have a 10 found higher affinity for PMCA4 than any other isoforms suggesting it is a suitable selective inhibitor for PMCA4 activity. The allosteric inhibitor is already being used in research to help understand the specific function of PMCA4 in tissues. Since changes in the levels of activity and expression of the PMCA isoforms have been linked to several conditions, such as hypertension and diabetes, clarifying the function of PMCA4 with the use of caloxin1C2 inhibitor could provide new treatments in the future.
Colore e forma:PowderPeso molecolare:1,843 g/molLCBiot-SGRGKGGKGLGKGGAKRHRKV-NH2
Peptide LCBiot-SGRGKGGKGLGKGGAKRHRKV-NH2 is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.
H-GFQALGDAADIR^-OH
Peptide H-GFQALGDAADIR^-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.H-VGDTSLDPNDFDFTVTGR^-OH
Peptide H-VGDTSLDPNDFDFTVTGR^-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.Ac-AGFAGDDAP-NH2
Peptide Ac-AGFAGDDAP-NH2 is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.
HLA-DRB1*1501 peptide
The HLA-DRB1*1501 peptide, is encoded by the disease-associated MHC allele histocompatibility leukocyte antigen (HLA)-DRB1*1501 which is present on the MHC region of chromosome 6. The increased frequency of the HLA-DRB*11501 haplotype found in Multiple Sclerosis (MS) patients, may contribute to the MS phenotype through disrupting T cell repertoire selection and through the presentation of self-peptides which can be targeted by the body's autoimmune response. Moreover studies investigating the accumulation of amyloid β-peptide (Aβ) as a factor producing Alzheimer's disease (AD) pathogenicity, found that HLA-DR alleles such as DRB1*1501 demonstrate immunogenic properties. It is evident that the DRB1*1501 halotype is associated with strong Aβ-T cell responses resulting in the large production of IFN- γ and IL-17. Therefore the HLA-DRB1*1501 peptide would be beneficial in studies exploring the phenotypes of autoimmune-diseases like MS and AD.Purezza:Min. 95%Colore e forma:PowderPeso molecolare:1,568.7 g/molH-IPVALGLK^-OH
Peptide H-IPVALGLK^-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.
H-FSVYWAQADR-NH2
Peptide H-FSVYWAQADR-NH2 is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.
CHKtide
CHKtide is a synthetic peptide substrate for checkpoint-kinase-1 and 2 (CHK1/CHK2) as well as salt-inducible kinase (SIKs) for use in kinase assays. CHKtide has been derived from CDC25C which is phosphorylated by CHK1/CHK2 in one of the DNA repair pathways. SIKs are serine/threonine kinases that are part of a complex network that regulate sodium homeostasis and blood pressure.The serine residue at position 5 of this peptide has been phosphorylated.
Purezza:Min. 95%Colore e forma:PowderPeso molecolare:2,699.5 g/molH-LITLAIPVNKPGR^-OH
Peptide H-LITLAIPVNKPGR^-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.H-FVFGTTPEDILR^-OH
Peptide H-FVFGTTPEDILR^-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.
Ac-Arg-Gly-Lys(Ac)-AMC trifluoroacetate salt
CAS:Ac-Arg-Gly-Lys(Ac)-AMC is a potent apoptotic agent that induces the apoptosis of cancer cells by binding to the caspase-9, which is an enzyme that initiates the process of apoptosis. Ac-Arg-Gly-Lys(Ac)-AMC has been shown to inhibit the growth of cancer cells in cell culture and also shows potent antitumor activity against MDA-MB-231 breast cancer cells. This drug can be used as a potential therapeutic agent for cancers such as colorectal, prostate, and pancreatic cancer. Ac-Arg-Gly-Lys(Ac)-AMC is also able to induce apoptosis in human leukemia cells and may have a potential role in therapy for acute myelogenous leukemia (AML).
Formula:C28H40N8O7•C2HF3O2Purezza:Min. 98 Area-%Colore e forma:PowderPeso molecolare:714.69 g/molC-terminal Sortagging-[Cys(AF680)] acid
This C-terminal Sortagging peptide acts as an (oligo)glycine nucleophile in the final steps of a sortagging protein labelling reaction. This reaction results in the [Cys(AF680)]- fluorescent moiety being attached to the C-terminus of the target protein or peptide.A substrate peptide containing the LPXTG motif is recognised and cleaved by the enzyme Sortase A (SrtA) from Staphylococcus aureus. The catalytic cysteine residue in the active site of SrtA serves as a nucleophile to cleave the peptide bond between threonine and glycine of the substrate peptide. Cleavage results in the formation of a thioacyl intermediate between the substrate peptide and SrtA. This intermediate is then resolved by the N-terminus of this (oligo)glycine nucleophile peptide, resulting in the creation of a new peptide bond that links the substrate peptide to this peptide and its fluorescent dye. This method of protein labelling is known as sortagging.C-Terminal Sortagging-[Cys(AF680)] contains the AF680 fluorescent dye- AF680 is a bright green dye with excitation at 633 nm, well suited for flow cytometry and imagery. AF680 is particularly photostable, allowing better detection of low abundance conjugates. C-Terminal Sortagging-[Cys(AF680)] acid is provided here. However, the amide version is also available.Purezza:Min. 95%Peso molecolare:1,241.3 g/molPAR-1 agonist/ TRAP6
CAS:Protease activated receptors (PARs) are a distinctive four-member family of seven transmembrane G protein-coupled receptors (GPCRs) widely expressed in inflammatory cells. PARs are cleaved by certain serine proteases to expose a tethered ligand domain, this ligand domain then binds to and activates the receptors to initiate multiple signalling cascades. These PAR-activating proteases therefore represent PAR agonists. This PAR-1 agonist peptide represents the sequence of the 'tethered ligand' and is therefore capable of activating the receptor independently of N-terminal proteolysis. TFLLR-NH2 is more selective to PAR-1 than the PAR-1 agonist SFLLRN-NH2.Activation of PAR-1 induces platelet aggregation and IL-6 release from monocytes and T cells, as well as several other cellular pathways including those involved in allergic inflammation, neurogenic inflammation and the potentiation of NMDA receptor activity in the hippocampus.
Formula:C31H53N9O6Purezza:Min. 95%Peso molecolare:647.8 g/molH-NPDDPDTVDVIMHMLDR^-OH
Peptide H-NPDDPDTVDVIMHMLDR^-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.
MOG (35-55) acid Mouse, Rat
CAS:Myelin oligodendrocyte glycoprotein (MOG) is a member of the immunoglobulin (Ig) protein superfamily and is expressed exclusively in the central nervous system on the surface of myelin sheaths and oligodendrocyte processes. MOG is expressed at the onset of myelination, and therefore is a potential marker for oligodendrocyte maturation.MOG contains an extracellular domain, a transmembrane domain, a cytoplasmic loop, a membrane-associated region and a cytoplasmic tail. MOG may function as a cell surface receptor or cell adhesion molecule. Fifteen different alternatively spliced isoforms have been detected in humans. These are present either on the cell surface, the endoplasmic reticulum in the endocytic system, or in secreted form.The secreted form of MOG may trigger autoimmunity if released into the cerebrospinal fluid and periphery. MOG is thought to be a key target for autoantibodies and cell-mediated immune responses in inflammatory demyelinating diseases such as multiple sclerosis (MS) and is therefore widely studied in this field.The MOG (35-55) fragment is the most potent auto-antigenic region of MOG, and the most effective at inducing experimental autoimmune/allergic encephalomyelitis (EAE), an animal model that resembles MS. This peptide has a free carboxylic acid at the C-terminus, an amide version is also available in our catalogue.Formula:C118H177N35O29SPurezza:Min. 95%Colore e forma:PowderPeso molecolare:2,581.95 g/molH-EFTPQMQAAYQK^-OH
Peptide H-EFTPQMQAAYQK^-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.
DRB1*01:01 gag DYVDRFYKTLRAE
Custom research peptide; min purity 95%. For different specs please use the Peptide Quote Tool[5-FAM]-GLP-1
Glucagon-like peptide (GLP)-1 is a gastrointestinal peptide hormone with multiple roles in relation to metabolism. The primary role of GLP-1 is increasing insulin secretion in the presence of high plasma glucose levels, in addition, GLP-1 also suppresses glucagon secretion from the pancreas. GLP-1 slows down gastric emptying and regulates appetite, both valuable in reducing food intake and body weight. These roles of GLP-1 make it a useful target in the management of type 2 diabetes mellitus (T2DM).GLP-1 exerts its effects by binding to and activating the class B G protein-coupled receptor (GPCR): GLP-1 receptor (GLP-1R). Receptor activation in turn activates signalling pathways which culminates in insulin secretion via CAMP and Ca2+ signalling.Recently evidence has increased for GLP-1 playing a cardio-protective role as well as regulating immune responses and even in kidney function. GLP-1 may also exert neuroprotective and neurotropic effects as it can decrease endogenous levels of amyloid-β (Aβ) and prevent Aβ-induced cell death.This peptide contains N-terminal 5-Carboxyfluorescein (5-FAM), a widely used green fluorescent tag.Purezza:Min. 95%Colore e forma:PowderPeso molecolare:4,467.1 g/molAoa-LALLAK-NH2
Peptide Aoa-LALLAK-NH2 is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.H-DIYSTDYYR^-OH
Peptide H-DIYSTDYYR^-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.
H-LADFADALEHPLR^-OH
Peptide H-LADFADALEHPLR^-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.H-VTGEVLDILTR^-OH
Peptide H-VTGEVLDILTR^-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.H-ASMTNMEL^M-OH
Peptide H-ASMTNMEL^M-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.H-ALVDQVIGSR^-OH
Peptide H-ALVDQVIGSR^-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.AIP-III
Staphylococcus aureus is a major human pathogen that utilizes autoinducing peptide (AIP) signals to regulate virulence. Methods to intercept bacterial quorum sensing (QS) aim to find novel anti-virulence treatments.Auto-inducing peptide (AIP) is a cyclic thiolactone quorum sensing peptide from Staphylococcus aureus which is responsible for activating the agr response. AIP is released from the bacteria and its extracellular concentration is then sensed by a two-component system on the bacterial surface, AgrC and AgrA. AgrC is the membrane histidine kinase receptor and AgrA is a response regulator- upon binding of AIP, AgrC phosphorylates AgrA.AIP accumulates during growth activating an AgrC and AgrA cascade when it reaches a critical signal level. This cascade activates P2 and P3 promoters which autoactivate the agr system and upregulate RNAIII transcription. RNAIII regulates the expression of virulence factors including toxins, super-antigens, and exo-enzymes. Extensive research to identify AIP:AgrC inhibitors aims to find therapeutics against pathogens.AgrD is the precursor peptide of AIP, and AgrB is an integral membrane endopeptidase essential to biosynthesize AIP. This AIP system is conserved among many Gram-positive bacteria. S. aureus strains are categorized into four groups (I-IV) according to their AIP signal and cognate extracellular receptor, AgrC. Each group is associated with a certain disease profile, and S. aureus group-III strains are responsible for toxic shock syndrome. AIP-III the conserved thiolactone macrocycle of the AIP family with an extended N terminal. Alanine scanning has identified a key trifactor of hydrophobic residues in the thiolatone ring that allow recognition by AgRC and the anchor point on the exocyclic tail needed for receptor activation. This knowledge is key for the design of novel AIP:AgrC inhibitors.
Purezza:Min. 95%Colore e forma:PowderPeso molecolare:818.4 g/molAF488 6xHis Tag
[AF488] 6xHis Tag, composed of a hexa-histidine tag and the fluorescent dye, Alexa Fluor 488 (AF488).Purezza:Min. 95%Peso molecolare:1,356.4 g/molMOTS-c
CAS:Custom research peptide; min purity 95%. For different specs please use the Peptide Quote ToolFormula:C101H152N28O22S2Colore e forma:PowderPeso molecolare:2,174.64 g/molH-FQSGIGEK^-OH
Peptide H-FQSGIGEK^-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.
H-Arg-Lys-OH acetate
CAS:H-Arg-Lys-OH acetate salt is a cyclic peptide that has been shown to have antimicrobial activity. It is an immunomodulator that has been shown to reduce the progression of autoimmune diseases by regulating the production of IgG, IgM and IgA. This drug is also a potent inhibitor of 2-adrenergic receptors in neuro2a cells and inhibits the release of IGF-I. H-Arg-Lys-OH acetate salt has been shown to be effective against infectious diseases such as meningitis, bronchitis, and pneumonia. It also inhibits proteolytic enzymes produced by bacteria, which may result in tissue damage.
Formula:C12H26N6O3•(C2H4O2)xPurezza:Min. 95%Colore e forma:PowderPeso molecolare:302.37 g/molSMAC/DIABLO-[Cys(AF647)]
SMAC/DIABLO-[Cys(AF647)] is a pro-apoptotic peptide that is derived from the mitochondrial protein known either as Second Mitochondria-Derived Activator of Caspases (Smac) or Direct IAP Binding Protein with low isoelectric point, pI (DIABLO). During apoptosis the mitochondria has increased permeability to Smac/DIABLO, which causes the protein to diffuse into the cytosol. Here, Smac/DIABLO adheres to Inhibitors of apoptosis proteins (IAPs) and prevents them from binding to caspases, which in turn accentuates apoptosis.This peptide has a C-terminal cysteine linker labelled with AF647, which is a bright, far-red-fluorescent dye with excitation between 594 nm and 633 nm.Purezza:Min. 95%Colore e forma:PowderPeso molecolare:1,427.7 g/molH-DT^AGQEEY-OH
Peptide H-DT^AGQEEY-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.
H-YNWNSFGLRF-NH2
Peptide H-YNWNSFGLRF-NH2 is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.H-VAIYEEFLR^-OH
Peptide H-VAIYEEFLR^-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.SBP1
Fragment of the angiotensin-converting enzyme 2 (ACE2) peptidase domain (PD) alpha1 helix, a domain important for the interaction of ACE2 with the severe acute respiratory syndrome (SARS coronavirus receptor binding domain (SARS-CoV-2-RBD). SBP1 associates with the SARS-CoV-2-RBD with nanomolar affinity and can potentially block the key mechanism by which SARS CoV-2 initiates entry into human cells.Purezza:Min. 95%Colore e forma:PowderGGG-[K(5-TAMRA)] C-terminal Sortagging
This C-terminal Sortagging peptide acts as a (oligo)glycine nucleophile in the final steps of a sortagging protein labelling reaction. This reaction results in the [Lys(5-TAMRA)]- fluorescent moiety being attached to the C-terminus of the target protein or peptide.A substrate peptide containing the LPXTG motif is recognised and cleaved by the enzyme Sortase A (SrtA) from Staphylococcus aureus. The catalytic cysteine residue in the active site of SrtA, serves as a nucleophile to cleave the peptide bond between threonine and glycine of the substrate peptide. Cleavage results in the formation of a thioacyl intermediate between the substrate peptide and SrtA. This intermediate is then resolved by the N-terminus of this (oligo)glycine nucleophile peptide, resulting in the creation of a new peptide bond that links the substrate peptide to this peptide and its fluorescent dye. This method of protein labelling is known as sortagging.5-Carboxytetramethylrhodamine (5-TAMRA) is a widely used fluorescent dye which excites at 546 nm and emits at 579 nm.Purezza:Min. 95%Colore e forma:PowderPeso molecolare:728.3 g/molIYPTNGYTR
CAS:Custom research peptide; min purity 95%. For different specs please use the Peptide Quote ToolFormula:C49H73N13O15Peso molecolare:1,084.18 g/molFmoc-Trp(Boc)-Ser(Psi(Me,Me)pro)-OH
CAS:Fmoc-Trp(Boc)-Ser(Psi(Me,Me)pro)-OH is a versatile building block that can be used in the synthesis of complex compounds. Fmoc-Trp(Boc)-Ser(Psi(Me,Me)pro)-OH is a high quality compound with a CAS No. 908601-15-0. This compound is useful as an intermediate or research chemical and can be used as a useful scaffold for making new compounds.
Formula:C37H39N3O8Purezza:Min. 95%Colore e forma:PowderPeso molecolare:653.72 g/molAF488 Insulin
Insulin is a peptide hormone produced by β cells of the pancreatic islets that regulates carbohydrates metabolism. It is a heterodimer of an A-chain and a B-chain, which are linked together by disulfide bonds. Insulin stimulates the absorption of glucose from the blood into fat, muscle and liver cells where it is converted into either glycogen or fat.Insulin is secreted in the blood as a response to high level of blood glucose resulting in enhanced glucose uptake and metabolism in the cells so to reduce blood glucose levels. Circulating insulin also affects the synthesis of proteins in many tissues. Low blood insulin levels result in catabolism, particularly of reserve body fat. A decrease or absence of insulin activity results in diabetes mellitus, a condition of high blood sugar level (hyperglycaemia).N-terminal chain B labelled with AF488. AF488 dye is a bright, green-fluorescent dye with excitation maxima around 490 and emission maxima around 525. AF488 dye is pH-insensitive over a wide molar range.Purezza:Min. 95%Peso molecolare:6,319.6 g/molLCBiot-LEVFYNGAWGTVGK-OH
Peptide LCBiot-LEVFYNGAWGTVGK-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.H-LITAHVEPLLAR^-OH
Peptide H-LITAHVEPLLAR^-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.H-RPK^PQQFFGLM-NH2
Peptide H-RPK^PQQFFGLM-NH2 is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.H-YGGFMTSEKSQTPLVTLFKNAIIK^NAHKKGQ-OH
Peptide H-YGGFMTSEKSQTPLVTLFKNAIIK^NAHKKGQ-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.GPS1573
GPS1573 is a potent and dose-dependent peptide antagonist of adrenocorticotrophic (ACTH) -stimulated melanocortin type 2 receptor (MC2R). Along with GPS1574, GPS1773 is an ACTH analogue and as such antagonises MC2R in the nanomolar range.The clinical relevance of GPS1573 is related to Cushing's disease and syndrome, which are both associated with a hypercortisolemic state. Selective antagonism of MC2R using GPS1573 may be a novel treatment modality for Cushing's disease and syndrome.Purezza:Min. 95%Colore e forma:PowderSARS-CoV-2 chain A spike glycoprotein (363-377)
Custom research peptide; min purity 95%. For different specs please use the Peptide Quote ToolH-YIPIQYVLSR^-OH
Peptide H-YIPIQYVLSR^-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.Biotin-PEG2-Claudin-3
Biotin-PEG2-Claudin-3 is derived from the tight junction protein Claudin-3 which is encoded by the CLDN3 gene located on chromosome 7q11.23 and can be found within epithelial cell to cell contacts. Structurally, the Claudin family are transmembrane proteins containing two extracellular loops and are involved in maintaining cell polarity and controlling paracellular ion flux.During cancer research reduction in the number of Claudins has been associated with tumour formation. This could be explained using Claudin role in maintaining cell detachment and migration although cancers such as breast and prostate have shown to overexpress both Claudin- 3 and Claudin-4. Similarly in ovarian cancer overexpression of Claudin 3 and 4 is thought to increase the motility of tumour cells and their survival through basement membrane degrading matrix metalloproteinase activation.Both Claudin 3 and 4 have potential to be used as diagnostic markers and their two extracellular loops may be used as targets for antibodies. As receptors for the Clostridium perfringens enterotoxin, Claudin 3 and 4 may have further use in targeting the enterotoxin as a therapeutic for ovarian cancers.This peptide has a covalently bonded N-terminal Biotin tag that can be used for detection and purification and contains a polyethylene glycol spacer (PEG2).
Purezza:Min. 95%Colore e forma:PowderPeso molecolare:2,947.5 g/molH-VHGLEIQGR^-OH
Peptide H-VHGLEIQGR^-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.
BRLF1 109-117 (HLA-A*02:01)
Custom research peptide; min purity 95%. For different specs please use the Peptide Quote Tool
CMVpp65 - 96 (YRHTWDRHDEGAAQG)
Custom research peptide; min purity 95%. For different specs please use the Peptide Quote Tool
Peso molecolare:1,798.9 g/molH-TTPPVLDSDGSFFLYSK-OH
Peptide H-TTPPVLDSDGSFFLYSK-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.
Ac-YLGR-OH
Peptide Ac-YLGR-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.
H-QNLLAPQNAVSSEETNDFK^-OH
Peptide H-QNLLAPQNAVSSEETNDFK^-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.H-Met-Leu-AMC·TFA
CAS:H-Met-Leu-AMC·TFA is a fine chemical that is useful as a building block in the synthesis of other chemicals. It is also used as a reagent in research, and it can be used as a speciality chemical. H-Met-Leu-AMC·TFA has been shown to be an excellent reaction component in the synthesis of complex compounds, and it can be used as an intermediate in the synthesis of pharmaceuticals. This chemical is soluble in organic solvents such as dichloromethane or chloroform, but it is insoluble in water. H-Met-Leu-AMC·TFA has been assigned CAS number 1926163-55-4.
Formula:C21H29N3O4S·C2HF3O2Purezza:Min. 95 Area-%Colore e forma:PowderPeso molecolare:533.56 g/molH-K^GAIIGLMVGGVV-OH
Peptide H-K^GAIIGLMVGGVV-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.
LCBiot-MGSSHHHHHHSSGLVPRGSH-OH
Peptide LCBiot-MGSSHHHHHHSSGLVPRGSH-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.[5-FAM]-RPKPQQFFGLM-NH2
Substance P (SP) is a peptide that is highly conserved across the animal kingdom and is involved in a number of inflammatory and growth promoting processes. SP has a net positive charge at physiological pH, it is an amphiphilic peptide with positively charged residues at the N-terminus and hydrophobic residues at the C-terminus, this controls how it interacts with cell membranes. SP is relatively stable in plasma (several hours) but has a short half-life in tissues (seconds/minutes).SP is encoded by the TAC1 gene and is a member of the tachykinin peptide hormone family. SP is expressed by many cell types including: neurons- astrocytes- microglia- epithelial cells- endothelial cells- immune cells such as T cells and macrophages- dendritic cells and eosinophils and some stem cells and progenitor cells. The huge variety of cell types expressing SP suggest it is involved in a wide variety of physiological and pathophysiological functions.SP mediates its functions by interacting with members of the neurokinin (NK) family of G protein-coupled receptors with high selectivity. Among these, SP binds to NK1R with the highest affinity, this receptor is expressed in a wide range of tissue types.[5-FAM]-Substance P contains 5-Carboxyfluorescein (5-FAM), a widely used green fluorescent tag.Purezza:Min. 95%Colore e forma:PowderPeso molecolare:1,704.8 g/molH-IGSLDNITHVPGGGNK^-OH
Peptide H-IGSLDNITHVPGGGNK^-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.(Phe2, Orn 8)-Oxytocin H-Cys-Phe-Ile-Gln-Asn-Cys-Pro-Orn-Gly-NH2 (Disulfide bond)
CAS:Oxytocin is a hormone that is produced in the hypothalamus and released by the pituitary gland. Oxytocin is a peptide consisting of nine amino acids, including two unusual ones: Cys (C) and Phe (F). This product has CAS number 2480-41-3. It is a reagent for use in chemical reactions, research chemicals, useful scaffold for synthetic chemistry, speciality chemical, versatile building block for synthetic chemistry, useful intermediate for synthetic chemistry, and useful building block for synthetic chemistry. It can be used as a fine chemical.Formula:C42H65N13O11S2Purezza:Min. 95%Colore e forma:Off-White PowderPeso molecolare:992.18 g/molH-LAVYQAGAR^-OH
Peptide H-LAVYQAGAR^-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.
Pancreastatin, Porcine
CAS:Custom research peptide; min purity 95%. For different specs please use the Peptide Quote ToolFormula:C214H330N68O76SPeso molecolare:5,103.4 g/molAcetyl-Alpha-2-antiplasmin-[AF680]
Alpha-2-antiplasmin (alpha2AP), a member of the serine protease inhibitor (SERPIN) superfamily, is the main inhibitor of the fibrinolytic enzyme plasmin as well as an inhibitor of trypsin, elastase, and C protein. It plays a crucial role in reducing plasmin production and activity and thus inhibiting fibrinolysis.alpha2AP is synthesized in the liver and secreted as a single-chain glycoprotein, containing 11-14% carbohydrate, with a methionine (Met) as its N-terminus (Met-alpha2AP). The N-terminus of alpha2AP is involved in the incorporation of alpha2AP into a clot and the C-terminus is involved in the initial interaction of alpha2AP with plasmin(ogen). Circulating alpha2AP undergoes both N-and C-terminal modifications, which alter its activity. Increased concentrations of a2AP are associated with a higher risk of cardiovascular diseases.Purezza:Min. 95%Peso molecolare:2,735.2 g/molH-LAKAVDGYVKPQIKQ-NH2
Peptide H-LAKAVDGYVKPQIKQ-NH2 is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.
H-FLPFQQFGR^-OH
Peptide H-FLPFQQFGR^-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.H-SSGLVSNAPGVQIR^-OH
Peptide H-SSGLVSNAPGVQIR^-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.
(Tos-GPR)2-[Rh110]
Fluorogenic substrate for thrombin that when in its intact state does not fluoresce, however upon cleavage by thrombin in 2 successive steps, Rhodamine 110 is released to allow fluorescence.Thrombin is a multifunctional serine protease and is the principal enzyme of hemostasis. It catalyzes the conversion of fibrinogen to fibrin and activates procoagulant factors V, VIII, XI, and XIII. When bound to thrombomodulin, it activates protein C, an anticoagulant zymogen. Thrombin also activates platelets, regulates endothelial cell function, and has a host of direct actions on other cells. Thrombin has been found to act as a mediator of vascular dysfunction and inflammation in both the peripheral and the central nervous systems. Thrombin contributes to the development of cardiovascular disease, atherosclerosis and diabetes and promotes vascular dysfunction, inflammation, and neurodegeneration. Thrombin is elevated in the brains of people with Alzheimer's disease (AD) and therefore may be a therapeutic target in AD.Purezza:Min. 95%Colore e forma:PowderPeso molecolare:1,259.42 g/mol(4S)-5-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-amino-1-oxo-3-phenylpropan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino ]-4-methyl-1-oxopentan-2-yl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-4-[[(2S)-2-[[(2S)-2,6-diaminohexanoyl]amino
CAS:Custom research peptide; min purity 95%. For different specs please use the Peptide Quote ToolFormula:C47H70N14O10Peso molecolare:991.17 g/molSpy-Tag peptide
SpyTag is a short peptide derived from the CnaB2 domain of the fibronectin-binding protein FbaB protein from Streptococcus pyogenes. The CnaB2 domain has a spontaneous isopeptide bond between Lys and Asp. By splitting and rational deisgn of this domain, the peptide (SpyTag) can be used in a pair to form an amide bond to its protein partner (SpyCatcher) in minutes. This ability to self-assemble through spontaneous isopeptide bond formation works across a wide range of aqueous buffer, pH and temperatures. Thsi system is therfore a valuable conjugation tool for biotechnolgy and bioengineering.Peptide tag forming a rapid covalent bond to a protein, through engineering a bacterial adhesinB. Zakeri, J.O. Fierer, E. Celik, E.C. Chittock, U. Schwarz-Linek, V.T. Moy, M. Howarth, Proc. Natl. Acad. Sci. U.S.A.109 (12) E690-E697 Catalyst-free thiazolidine formation chemistry enables the facile construction of peptide/protein-cell conjugates (PCCs) at physiological pH X Liu, Y Wang, B Ye, X Bi - Chemical Science, 2023 - pubs.rsc.orghttps://pubs.rsc.org/en/content/articlehtml/2023/sc/d3sc01382k AlbuCatcher for Long-Acting Therapeutics JH Rho, JH Lee, I Kwon - ACS omega, 2024 - ACS Publicationshttps://pubs.acs.org/doi/abs/10.1021/acsomega.4c02303 T Cell Activating Thermostable Self-Assembly Nanoscaffold Tailored for Cellular Immunity Antigen Delivery J Zhang, J Yang, Q Li, R Peng, S Fan, H Yi - Advanced , 2023 - Wiley Online Libraryhttps://onlinelibrary.wiley.com/doi/abs/10.1002/advs.202303049Colore e forma:PowderGP dipeptide
Glycine proline (Gly-Pro) dipeptide is a bioactive collagen hydrolysate. Ingestion of collagen hydrolysate improves skin health. Gly-Pro ingestion specifically attenuates UVB-induced damage including wrinkle formation, trans-epidermal water loss, and epidermis thickness- Gly-Pro also increases skin hydration.
Purezza:Min. 95%Colore e forma:PowderPeso molecolare:172.1 g/molAc-RKST-NH2
Peptide Ac-RKST-NH2 is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.
Glucagon (1-29)-[Lys(AF647)]
Glucagon (1-29)-[Lys(AF647)] is derived from glucagon, which is a peptide hormone secreted by alpha cells located in the islet of Langerhans region of the pancreas. Glucagon is an essential catabolic hormone that is responsible for the regulation of blood glucose levels. Once released into the bloodstream, glucagon stimulates the production of hepatic glucose, which means it is considered to be a glucose-mobilizing agent. Excessive levels of glucagon can result in the development of hyperglycaemia, since the action of glucagon results in abnormally high blood glucose levels.This peptide contains AF647, structural analog to Alexa Fluor® 647 which is a widely used far-red fluorescent dye.Purezza:Min. 95%Colore e forma:PowderPeso molecolare:4,750 g/molH-GHDVTFYK^-OH
Peptide H-GHDVTFYK^-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.AIP-IV
Staphylococcus aureus is a major human pathogen that utilizes autoinducing peptide (AIP) signals to regulate virulence. Methods to intercept bacterial quorum sensing (QS) aim to find novel anti-virulence treatments.Auto-inducing peptide (AIP) is a cyclic thiolactone quorum sensing peptide from Staphylococcus aureus which is responsible for activating the agr response. AIP is released from the bacteria and its extracellular concentration is then sensed by a two-component system on the bacterial surface, AgrC and AgrA. AgrC is the membrane histidine kinase receptor and AgrA is a response regulator- upon binding of AIP, AgrC phosphorylates AgrA.AIP accumulates during growth activating an AgrC and AgrA cascade when it reaches a critical signal level. This cascade activates P2 and P3 promoters which autoactivate the agr system and upregulate RNAIII transcription. RNAIII regulates the expression of virulence factors including toxins, super-antigens, and exo-enzymes. Extensive research to identify AIP:AgrC inhibitors aims to find therapeutics against pathogens.AgrD is the precursor peptide of AIP, and AgrB is an integral membrane endopeptidase essential to biosynthesize AIP. This AIP system is conserved among many Gram-positive bacteria. S. aureus strains are categorized into four groups (I-IV) according to their AIP signal and cognate extracellular receptor, AgrC. Each group is associated with a certain disease profile, S. aureus group-IV strains have been associated with generalized exfoliative syndromes and osteoarticular infections. AIP-IV has been used to develop antibodies and an effective ELISA help detect AIP-IV levels in the nanomolar range. This can be implemented to identify S. aureus type IV infections in patient samples.
Purezza:Min. 95%Colore e forma:PowderPeso molecolare:1,008.4 g/molCOG1410
CAS:Custom research peptide; min purity 95%. For different specs please use the Peptide Quote ToolFormula:C64H121N21O14Peso molecolare:1,408.78 g/molH-VVLSQGSK^-OH
Peptide H-VVLSQGSK^-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.
hsBCL9CT-24
Blocks the Wnt pathway and inhibits the expression of TGFb1 in CT26 colon carcinoma cells, leading to the reduction of CCL20 and CCL22, two TGF-b- dependent chemokines critical for Treg cell recruitment into the tumour microenvironment. hsBCL9CT-24 shows robust antitumour efficacy across multiple in vivo models.
Purezza:Min. 95%Colore e forma:PowderPeso molecolare:1,629 g/molH-THFPQFSYSASIR^E-OH
Peptide H-THFPQFSYSASIR^E-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.
Angiotensin (Human, 1-7)
CAS:Angiotensin 1-7 (Ang-(1-7)) is a component of the renin angiotensin system RAS. Ang-(1-7) is produced by angiotensin-converting enzyme 2 (ACE2), from the angiotensin II (Ang-II) peptide, as well as by prolylendopeptidase (PEP) and neutral endopeptidase (NEP) which produce Ang-(1-7) directly from angiotensin I (Ang-I).Ang-(1-7) broadly opposes Ang-II actions. Ang-(1-7) has vasodilatory and anti-oxidative effects, and exerts protective actions in hypertension, diabetes, and other cardiovascular disorders, Ang-(1-7) therefore represents a promising therapeutic target for cardiovascular and metabolic diseases. Ang-(1-7) exerts its actions via its G-protein-coupled receptor, Mas. This novel arm of the RAS has effects that counterbalance those mediated by the classical ACE/Ang-II pathway.Formula:C41H62N12O11Purezza:Min. 95%Colore e forma:PowderPeso molecolare:899.01 g/molHIV - 1 MN ENV - 27
Custom research peptide; min purity 95%. For different specs please use the Peptide Quote Tool
Peso molecolare:1,746 g/molH-AAVYHHFISDGVR^-OH
Peptide H-AAVYHHFISDGVR^-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.
H-QQFFGLM-NH2
Peptide H-QQFFGLM-NH2 is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.
OVA (323-339)
CAS:Ovalbumin (OVA) is the primary protein in egg-white, and is involved in initiating food allergies and asthma. It is a highly immunogenic protein and can be used for peptide conjugation in the development of antibodies.OVA (323-339) is a class I (Kb)-restricted peptide epitope of OVA. The ovalbumin fragment is presented by the class I MHC molecule, H-2Kb.Formula:C74H120N26O25Purezza:Min. 95%Colore e forma:PowderPeso molecolare:1,773.93 g/molFormyl-Δ-toxin (1-26)
θ-toxin forms pores on the surface of host cells which can lead to cytolysis or activation of the inflammatory response. θ-toxin can induce mast cell degranulation. The toxin produced by S.aureus has been strongly linked to atopic dermatitis. As a natural antimicrobial it has been used as a template for novel and more potent antimicrobial peptides.Purezza:Min. 95%Colore e forma:PowderPeso molecolare:3,006.56 g/molAc-CAF-NH2
Peptide Ac-CAF-NH2 is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.H-DAAQK^TDTSHHDQDHPTF-OH
Peptide H-DAAQK^TDTSHHDQDHPTF-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.PADRE scrambled
SB-peptide offers the scrambled version of PADRE peptide. AAATLWKAAKFVA can be used as a negative control of PADRE peptide studies. SB-peptide offers also PADRE peptide (see section PADRE peptide). PADRE peptide: Pan HLA DR-binding epitope is a universal peptide that activates antigen specific-CD4+ T cells which can be used as an agonist adjuvant in immunotherapeutic vaccine development. Pan HLA DR-binding epitope has been proposed as a carrier epitope suitable for use in the development of synthetic and recombinant vaccines. It has been demonstrated that PADRE may be an universal approach to control tumor cells. Moreover, PADRE is also used in research about an immunosense approach to develop a base for development of vaccines against toxoplasmosis to protect person with HLA-A*03 type. Pan HLA DR-binding epitope can be also used as tool to study the autoreactive T cell response.Formula:C65H100N16O14Colore e forma:PowderPeso molecolare:1,347.60 g/molβ-Neo-Endorphin
Peptide β-Neo-Endorphin is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.
Formula:C54H77N13O12Peso molecolare:1,100.3 g/molAngiotensin I-converting enzyme inhibitor ITT
Custom research peptide; min purity 95%. For different specs please use the Peptide Quote ToolFormula:C14H27N3O6Peso molecolare:333.38 g/molH-NAINNGVR^-OH
Peptide H-NAINNGVR^-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.
CMVpp65 - 34 (SAAERKHRHLPVADA)
Custom research peptide; min purity 95%. For different specs please use the Peptide Quote ToolPeso molecolare:1,657.9 g/molAc-CENQIYDLPEGAHEHFPV-OH
Peptide Ac-CENQIYDLPEGAHEHFPV-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.Ara h1 (555-577) peanut allergen
Ara h 1 is one of the major allergenic proteins from peanut (Arachis hypogaea) which contains approximately 13 potential allergenic proteins.Ara h 1 is a member of the 7/8 S globulin (vicilin) family of seed storage proteins belonging to the cupin superfamily and is the most abundant allergen present in the peanut kernel. Ara h 1 plays an important role in the allergy sensitising procedure and can be recognised by 90% of patients with a peanut allergy.This peptide represents a tryptic peptide of Ara h 1.Purezza:Min. 95%Colore e forma:PowderPeso molecolare:1,375.7 g/mol
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