Peptidi
I peptidi sono catene corte di amminoacidi legate da legami peptidici, che svolgono ruoli chiave come molecole biologiche importanti nei processi cellulari. Funzionano come ormoni, neurotrasmettitori e molecole di segnalazione, e sono ampiamente utilizzati in applicazioni terapeutiche e diagnostiche. I peptidi sono anche cruciali nella ricerca per lo studio delle interazioni proteiche, delle attività enzimatiche e dei percorsi di segnalazione cellulare. Presso CymitQuimica, offriamo una vasta selezione di peptidi di alta qualità per supportare le vostre esigenze di ricerca e sviluppo in biotecnologia e farmacologia.
Sottocategorie di "Peptidi"
Trovati 29633 prodotti di "Peptidi"
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Neuropeptide S human
Neuropeptide S (NPS) is a neuropeptide found in mammalian brains, primarily in neurons in the lateral parabrachial nucleus, the peri-locus coeruleus and the principle sensory 5 nucleus of the trigeminus. NPS in involved in several neuroendocrine, behavioural and inflammatory responses, including: reducing anxiety in mice- suppressing appetite and inducing wakefulness and hyperactivity. NPS treatment can be used to improve fear extinction in mice and limit fear memory retrieval after fear reduction training, thus making it an interesting target for treatment of post-traumatic stress disorder. NPS exerts its actions by binding to a G-protein coupled receptor, NPSR.Peso molecolare:2,186.1 g/molH-FQTAAQR^-OH
Peptide H-FQTAAQR^-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.survivin (baculoviral IAP repeat-containing protein 5) (21-28)
Survivin is an intracellular tumour-associated antigen that is part of the inhibitor of apoptosis (IAP) family. Survivin expression increases as cells age but becomes over-expressed in cancer cells. Expression is also important during embryonic development and tissue regeneration. With roles in aging, apoptosis, and cancer, there is considerable interest in understanding the function of Survivin. Survivin expression is regulated by TGF-β and increased following intestinal inflammation during the healing process.The high expression of Survivin in cancer cells has led to the search for a vaccine that induces epitope-specific CD8+ T cells. The epitope TFKNWPFL restricted to H-2 Db was identified using prediction algorithms and MHC class I binding assays. The epitope was delivered to mice by intradermal electroporation (EP). The Survivin epitope induced a CD8+ cytotoxic T lymphocyte (CTL) response as shown by IFN-staining- they also showed an activated effector phenotype as CD44 and CD107 were upregulated. The Survivin vaccine was able to confer protection against melanoma in mice and suppress angiogenesis. This Survivin epitope could be a vital step in creating a human vaccine that generates CD8 CTLs with specific functional cytotoxic activity against tumour cells.The sequence provided here aligns to residues 21-28 of the Survivin epitope, the initial residue of the epitope has been omitted as it is not conserved between mice and human sequences.Peso molecolare:1,051.5 g/molSARS-CoV-2 Nucleoprotein (353-370)
The coronavirus (CoV) nucleoprotein is the major component of CoV structural proteins. Also known as the nucleocapsid protein, it is an abundant RNA-binding protein critical for viral genome packaging. These factors make nucleoprotein a good target for developing new antiviral drugs. In addition, the identification of epitopes within the nucleoprotein sequence can help design more effective SARS-CoV-2 vaccines.Models have predicted epitopes exhibiting antigenicity, stability and interactions with MHC class-I and class-II molecules. Nucleoprotein (353-370) is an epitope candidate with various HLA restrictions. This epitope can be used to better vaccine design for more durable CD4+ and CD8+ T cell responses for long-lasting immunity.Peso molecolare:2,111.1 g/molH-SVILLGR^-OH
Peptide H-SVILLGR^-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.
Apelin (65-76), human
Apelin (65-76), human is derived from the apelin peptide which acts as a ligand for the apelin receptor (APJ) G protein coupled receptor and is a substrate for angiotensin converting enzyme 2. Preprapelin, encoded for by APLN located on Xq25-26.1, is cleaved to form either apelin 36 or apelin 17, 12 and 13. As a member of the adipokine hormone family, which are involved in processes such as vascular homeostasis and angiogenesis, the apelin is secreted from adipose tissue.Apelin has been found to be expressed in the spinal cord and the human brain and when performing immunohistochemistry it was observed that apelin-17 is significantly expressed in the human heart, brain, lungs and endothelial cells.Both apelin and the apelin receptor are widely distributed around the body thus apelin has been found to be associated with cardiovascular diseases, obesity, diabetes and cancer. Studies exploring myocardial infarction showed there to be greater apelin mRNA expression during human heart failure compared to in healthy tissue. Apelin protects against heart failure due to, the pyroglutamyl form of apelin, playing a role in decreasing infarct size of myocardial infarctions. Furthermore in rats with hypertension, the expression of apelin and APJ was decreased.Peso molecolare:1,402.8 g/molSARS-CoV epitope peptide
The epitope of SARS-CoV could be used in vaccine design.. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.Formula:C47H58N10O12Peso molecolare:973.04 g/molH-VVLSQGSK^-OH
Peptide H-VVLSQGSK^-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.
Keap1 peptide fragment
Keap1 peptide fragment is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.Formula:C66H94N18O18SPeso molecolare:1,477.64 g/molSmMLCKp, Smooth-Muscle Myosin Light-Chain Kinase (796-815), Calmodulin Binding
CAS:Custom research peptide; min purity 95%. For different specs please use the Peptide Quote ToolFormula:C98H168N38O25Peso molecolare:2,278.7 g/molH-MQQVEASLQPETLR^-OH
Peptide H-MQQVEASLQPETLR^-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.
Neurotensin
Neurotensin (NT) is involved in food absorption in the gut as well as acting as a neurotransmitter in the central nervous system (CNS). In the intestine, NT increases fatty acid translocation, in part by increasing intestinal blood flow. In the CNS, NT regulates pathways associated with ghrelin and leptin which mediate satiety and food ingestion. NT is also involved in the regulation of Luteinizing hormone (LH) and Prolactin release and also plays a role in hypotension- analgesia- gut contraction- vascular permeability- maintaining energy homeostasis- fat storage and metabolic disorders. Higher plasma pro-NT levels are associated with obesity and insulin resistance. NT is therefore a potential target for treating obesity-related diseases.NT is secreted from neuroendocrine cells in the small intestine upon fat intake and exerts its physiological actions by binding three NT receptor (NTR) types- NTR1, NTR2, and NTR3.NTR1 is highly expressed in various tumour cells including- small cell carcinoma/small cell lung cancer (SCLC)- meningiomas- astrocytomas- glioblastoma- pancreatic and colonic carcinoma, and breast and prostate cancers. NTR1 is therefore a possible target for novel cancer therapy.
Peso molecolare:1,801 g/molNR-Box 2 Peptide
Custom research peptide; min purity 95%. For different specs please use the Peptide Quote ToolPeso molecolare:1,574.9 g/molHistone H2A (1-20)
The histone H2A residues 1-20 are derived from histone 2A (H2A) which is one of the four core his-tones (H2A, H2B, H3 and H4) fundamental in compacting eukaryotic DNA into a structure known as the nucleosome. The nucleosome arises when 147 base pairs of DNA wrap around a H3-H4 tetramer and two H2A-H2B dimers, forming the histone octamer core.At the site of DNA entry on the outer nucleosome, the C-terminus of H2A is present and is able to interact with linker histones or other factors. This allows for variation and changes in nucleosome stability to occur. Furthermore Histone H2A has histone variants such as H2A.Z and H2A.X (which are present in all organisms) and these variants alter the organisation of the DNA.Due to histones containing a large number of lysine and arginine residues they have a positive net charge which interacts in an electrostatic manner with the negatively charged phosphate groups in DNA. The transcriptional activation or silencing of the chromatin is controlled by ATP-dependent chromatin remodelling factors and histone modifying enzymes which target histone proteins. Both processes function to alter to change the positioning of the nucleosome, allowing the DNA it to be either available to the transcription machinery or inaccessible.Peso molecolare:2,086.2 g/mol[5-FAM]-beta-Amyloid (1-15) Human
Fluorescein labelled amyloid β 1-15 (Aβ1-15 ). Aβ1-15 is one of many short Aβ species found in vivo and is formed by the cleavage of Aβ precursor protein by β- and alpha-secretase.Amyloid β-protein (Aβ) has been identified as the key subunit of the extracellular plaques found in the brains of patients with Alzheimer's disease (AD) and Down's syndrome (DS). Aβ has therefore been extensively studied as a potential target for treatment of AD.Aβ is formed from the cleavage of the large, transmembrane protein- APP (amyloid precursor protein). Cleavage of APP by β- and then γ-secretases results in the formation of Aβ. Aβ can aggregate to produce amyloid-β oligomers, which are thought to be highly neurotoxic. Over time Aβ can further aggregate to produce the characteristic senile plaques present in AD and DS. Aβ can be degraded by enzymes such as neprilysin, insulin degrading enzyme or endothelin converting enzyme. At physiological levels Aβ may be involved in controlling synaptic activity and neuronal survival.Fluorescein (FAM) is a hugely popular fluorescent tag due to its excellent fluorescence quantum yield and relatively high absorptivity as well as being highly water soluble.Peso molecolare:2,183.8 g/molAzido-dPEG®4-NHS ester
CAS:Azido-dPEG®4-NHS ester is a PEG compound with two different functional groups (also known as heterobifunctional). Unlike homobifunctional PEG compounds (same functional group on both ends), this type of compounds are more versatile as have two different anchor points. Azido-dPEG®4-NHS ester is used as a linker and spacer to add a PEG moiety, via pegylation (a bioconjugation technique) to proteins, peptides, oligonucleotides, small molecules and nanoparticles.Formula:C15H24N4O8Purezza:Min. 95%Peso molecolare:388.37 g/molSAMS peptide
SAMS peptide was originally designed as a selective substrate for mammalian 5' adenosine monophosphate-activated protein kinase (AMPK) for use in kinase assays. However it is also able to be phosphorylated by the yeast AMP homologue- sucrose non-fermenting 1 kinase (SNF1) and SNF1-related kinases (SnRK1) in plants.The conserved family of kinases containing SnRK1, SNF1 and AMPK plays an important role in regulating cellular energy homeostasis.
Colore e forma:PowderPeso molecolare:1,779.15 g/molH-RPTLR^-OH
Peptide H-RPTLR^-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.H-LSITGTYDLK^-OH
Peptide H-LSITGTYDLK^-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.
![[5-FAM]-beta-Amyloid (1-15) Human](/_next/image/?url=https%3A%2Fstatic.cymitquimica.com%2Fproducts%2F3D%2Fthumb-webp%2FCRB1100839.webp&w=3840&q=75)
