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Peptidi

Peptidi

I peptidi sono catene corte di amminoacidi legate da legami peptidici, che svolgono ruoli chiave come molecole biologiche importanti nei processi cellulari. Funzionano come ormoni, neurotrasmettitori e molecole di segnalazione, e sono ampiamente utilizzati in applicazioni terapeutiche e diagnostiche. I peptidi sono anche cruciali nella ricerca per lo studio delle interazioni proteiche, delle attività enzimatiche e dei percorsi di segnalazione cellulare. Presso CymitQuimica, offriamo una vasta selezione di peptidi di alta qualità per supportare le vostre esigenze di ricerca e sviluppo in biotecnologia e farmacologia.

Sottocategorie di "Peptidi"

Trovati 29608 prodotti di "Peptidi"

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  • [Rhodamine Green]-LifeAct (Abp140 1-17)


    [Rhodamine Green]-LifeAct (Abp140 1-17) contains the 17amino acid peptide Lifeact derived from amino acids 1-17 of the Saccharomyces cerevisiae actin binding protein, Abp140. These first 17 amino acids of Abp140 are crucial in allowing Lifeact to localise to actin filaments (F-actin) and therefore it can be used as a cytoskeletal marker. On application, lifeact can be used in the study of plant development and pathogen defence as filamentous actin within the plant actin cytoskeleton is important in key processes such as cell division, membrane trafficking and stomatal movements.The addition of the Rhodamine Green fluorophore, Rhodamine Green allows the location of the LifeAct (Abp140 1-17) to be detected.
    Peso molecolare:2,279.1 g/mol

    Ref: 3D-CRB1100899

    100µg
    206,00€
    500µg
    282,00€
    1mg
    386,00€
  • Dinitrophenyl ERAP1 peptide


    WRVYEKC(Dnp)ALK-acid
    Peso molecolare:1,600.7 g/mol

    Ref: 3D-CRB1100903

    100µg
    346,00€
    500µg
    386,00€
    1mg
    470,00€
  • H-ITQSNAILR^-OH


    Peptide H-ITQSNAILR^-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.

    Ref: 3D-PP49698

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  • Biotin-aMp3


    Biotinylated aMp3 is a Mycobacterium avium subsp. Paratuberculosis (MAP) specific ligand. MAP can cause Johne disease (the wasting disease) in livestock. It is important therefore to detect the presence of MAP in animal milk and faeces.Biotinylated aMp3 can be used (along with aMptD peptides) to detect the viability of MAP cells in infected livestock through combined peptide-mediated magnetic separation phage display due to their high affinity for MAP. The addition of biotin to aMp3 asparagine residue, changes the orientation of aMp3 so that it can bind to the target bacteria with increased stability, thus achieving a high capture efficiency. A similar effect is observed on the addition of biotin to aMptD glycine residue.
    Peso molecolare:1,642.8 g/mol

    Ref: 3D-CRB1000741

    500µg
    206,00€
    1mg
    282,00€
  • Tau Peptide (306-317) trifluoroacetate salt

    CAS:
    Custom research peptide; min purity 95%. For different specs please use the Peptide Quote Tool
    Formula:C65H109N15O18
    Peso molecolare:1,388.67 g/mol

    Ref: 3D-PP50814

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  • H-Ala-Pro-Arg-Lys-Gln-Leu-Ala-Thr-Lys-Ala-Ala-Arg-Lys(Me3)-Ser-Ala-Pro-Ala-Thr-Gly-Gly-OH


    Custom research peptide; min purity 95%. For different specs please use the Peptide Quote Tool

    Formula:C87H157N30O25
    Peso molecolare:2,023.38 g/mol

    Ref: 3D-PP50278

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  • EBV EBNA3A (325-333) (HLA-B8)


    Portion of EBV EBNA 3A

    Peso molecolare:1,051.6 g/mol

    Ref: 3D-CRB1001460

    500µg
    206,00€
    1mg
    282,00€
  • Biotin HER-2 substrate peptide


    Human epidermal growth factor receptor (HER-2)/epidermal growth factor receptor-2 (ErbB-2), is a key receptor linked to metastasis in tumours. The oncogenic ErbB-2 receptor has intrinsic receptor tyrosine kinase (RTK) activity, the receptor is activated by ligand binding which induces receptor dimerization. These RTK complexes can activate mitogen-activated protein kinase (MAPK) and phosphoinositol 3-kinase (PI3K)/Akt pathways. This peptide has been identified as a substrate for HER-2/ErbB-2 as it is phosphorylated upon receptor activation and therefore acts as a marker for receptor activation in kinases assays. Contains a covalently attached N-terminal biotin tag for convenient detection and purification.
    Peso molecolare:2,062.44 g/mol

    Ref: 3D-CRB1000260

    500µg
    254,00€
    1mg
    332,00€
  • H-EFSEVEGR^-OH


    Peptide H-EFSEVEGR^-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.

    Ref: 3D-PP47452

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  • BAM (8-22)


    BAM (8-22), the Bovine adrenal medulla 8-22 peptide is synthesised from proekephalin after it has undergone proteolytic cleavage. It can induce what is known as the 'itching' or 'scratching' response through activating, using an opioid independent mechanism, the G-protein coupled receptor MRGPRX1. This subsequently activates the Gαq/11 pathway and the cation channel TRPA1 histamine independent itch pathways.It is believed that BAM 8-22 can contribute to chronic itching in diseases such as cholestasis-related pruritus, in which patients are commonly diagnosed as having a reduction in bile flow.
    Peso molecolare:1,971.2 g/mol

    Ref: 3D-CRB1000218

    500µg
    206,00€
    1mg
    282,00€
  • H-HIATNAVLFFGR^-OH


    Peptide H-HIATNAVLFFGR^-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.

    Ref: 3D-PP49423

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  • Palmitoyl GHK tripeptide


    The GHK tripeptide has many attributes which can positively impact human health. GHK can improve tissue repair, exhibit anti-cancer and anti-inflammatory properties, suppress age related molecules and restore chronic obstructive pulmonary disease fibroblasts.The GHK tripeptide is found in the human plasma and binds copper. It exerts its effects through its ability to up regulate and downregulate 4,000 human genes. Due to its ability to protect and regenerate aspects of human health, GHK-Cu can be used in products for skin and hair.Specifically during skin regeneration GHK-Cu can promote the synthesis of collagen and glycosa-minoglycans, increase the rate of wound healing and the formation of blood vessels.A palmitoyl group is present on the N-terminus.
    Peso molecolare:578.4 g/mol

    Ref: 3D-CRB1001050

    500µg
    206,00€
    1mg
    282,00€
  • SIVmac239 envelope - 86


    Custom research peptide; min purity 95%. For different specs please use the Peptide Quote Tool
    Peso molecolare:2,478 g/mol

    Ref: 3D-PP50019

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  • H-VVV^GAVGVGK^-OH


    Peptide H-VVV^GAVGVGK^-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.

    Ref: 3D-PP48026

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  • β-Amyloid (12-20)


    Aβ has been identified as the key subunit of the extracellular plaques found in the brains of patients with Alzheimer's disease (AD) and Down's syndrome (DS). Aβ has therefore been extensively studied as a potential target for treatment of AD.Aβ is formed from the cleavage of the large, transmembrane protein- APP (amyloid precursor protein). Cleavage of APP by β- and then γ-secretases results in the formation of Aβ. Aβ can aggregate to produce amyloid-β oligomers, which are thought to be highly neurotoxic. Over time Aβ can further aggregate to produce the characteristic senile plaques present in AD and DS. Aβ can be degraded by enzymes such as neprilysin, insulin degrading enzyme or endothelin converting enzyme. At physiological levels Aβ may be involved in controlling synaptic activity and neuronal survival.
    Colore e forma:Powder
    Peso molecolare:1,153.6 g/mol

    Ref: 3D-CRB1001403

    500µg
    206,00€
    1mg
    282,00€
  • H-DSLYLQMNSLR^-OH


    Peptide H-DSLYLQMNSLR^-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.

    Ref: 3D-PP46010

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  • CMX-8933


    The CMX-8933 peptide is a fragment of the goldfish brain neurotrophic factor ependymin which can increases the enzymatic activity of c-Jun N-terminal kinase (JNK), increase the phosphorylation of JNK and c-Jun proteins, and increase cellular levels of c-Jun and c-Fos mRNAs.
    Peso molecolare:1,192.6 g/mol

    Ref: 3D-CRB1001208

    500µg
    206,00€
    1mg
    282,00€
  • Ac-GPLD-[Rh110]-[D-Pro]


    Fluorogenic substrate peptide to assay the caspase-like peptidic activity of the 20S proteasome. In its intact state this peptide is non-fluorescent, however when the Rhodamine fluorophore is released upon hydrolysation, fluorescence can be detected. This peptide is therefore a useful tool for analysing enzyme activity.The presence of the D-proline residue on the C terminal of the rhodamine molecule ensures one directional rhodamine cleavage which simplifies fluorescence studies. Rhodamine 110 is a laser grade fluorescent dye with excitation maxima at 496 nm and emission maxima at 522 nm.
    Peso molecolare:851.3 g/mol

    Ref: 3D-CRB1101107

    1mg
    1.028,00€
    5mg
    3.774,00€
  • GS dipeptide


    Dipeptide consisting of one glycine and one serine residue with diverse uses. Primary metabolite and bronsted base, forms a complex with Cu(II) acting as a tridentate ligand.Primary metabolites are metabolically or physiologically essential and are directly involved in an organism's development, growth, or reproduction.
    Peso molecolare:162.1 g/mol

    Ref: 3D-CRB1001603

    500µg
    206,00€
    1mg
    282,00€
  • H-Tyr-Ala-Pro-Gly-Lys-Phe-NH2


    H-Tyr-Ala-Pro-Gly-Lys-Phe-NH2 is a synthetic peptide that can activate the PAR4 receptor. The PAR4 receptor is activated by proteolytic cleavage, which occurs when PAR4 interacts with the enzyme thrombin. Activation of the PAR4 receptor leads to vasodilation and increased blood flow. H-Tyr-Ala-Pro-Gly-Lys-Phe NH2 has shown potential for use in cardiovascular diseases such as hypertension, which is characterized by elevated blood pressure.
    Formula:C34H48N8O7
    Purezza:Min. 95%
    Peso molecolare:680.81 g/mol

    Ref: 3D-PAR-3933-PI

    1mg
    136,00€
    5mg
    306,00€
  • H-ENATVAHLVGALR^-OH


    Peptide H-ENATVAHLVGALR^-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.

    Ref: 3D-PP46148

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  • Ac-CS-NH2


    Peptide Ac-CS-NH2 is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.

    Ref: 3D-PP44826

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  • Ac-LSHVLYSIAFED-NH2


    Peptide Ac-LSHVLYSIAFED-NH2 is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.

    Ref: 3D-PP47960

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  • H-SFNPNSPGK^-OH


    Peptide H-SFNPNSPGK^-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.

    Ref: 3D-PP40801

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  • H-HHAAYVNNLNVTEEK^-OH


    Peptide H-HHAAYVNNLNVTEEK^-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.

    Ref: 3D-PP49495

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  • GRGD-[Cys(AF647)]


    GRGD-acid is a cell adhesive peptide containing the RGD motif. This enables it the ability to increase cell adhesion and rates of cell growth, differentiation and proliferation.When immobilised onto a Poly(etheretherketone) (PEEK) surface it has been shown to increase cell adhesion and proliferation in MC3T3-E1 cells. GRGD could therefore be used in dental implants.This peptide contains a C-terminal Alexa Fluor 647 florescent dye. A cysteine residue has been added to the C-terminus for conjugation of the dye via the cysteine thiol moiety. AF647 is a bright, far-red-fluorescent dye with excitation between 594 nm and 633 nm, and is pH-insensitive over a wide molar range.
    Colore e forma:Powder
    Peso molecolare:1,486.2 g/mol

    Ref: 3D-CRB1110931

    500µg
    386,00€
    1mg
    543,00€
  • α-Casozepine

    CAS:
    Alpha-Casozepine (alpha-CZP) is a tryptic hydrolysate of bovine milk alphas1-casein. The presence of bile salts facilitates alpha-CZP absorption through a Caco2 monolayer. alpha-CZP shows similarities to benzodiazepines with its anxiolytic-like activity but lack the common side effects of habituation or sedation. alpha-CZP binds to the GABAA receptor at the benzodiazepine site.  alpha-CZP binds with a significantly lower affinity than benzodiazepines.Intraperitoneal administration of Alpha-Casozepine (alpha-CZP) to rodents results in anticonvulsant and sleep-protecting effects. Human administration reduces physiological stress symptoms in stressed and control patients. alpha-CZP modulated neuronal activity in brain regions linked to anxiety regulation in mice.
    Formula:C60H94N14O16
    Peso molecolare:1,267.47 g/mol

    Ref: 3D-CRB1001691

    500µg
    206,00€
    1mg
    282,00€
  • D-Arg PEP


    An inhibitor of E2F1 and 3a transcription, with a D substituted arginine which confers resistance to proteolysis after pre-incubation in serum. Cytotoxic to several malignant cell lines and human prostate and small cell lung cancer xenografts.

    Ref: 3D-CRB1001382

    500µg
    206,00€
    1mg
    282,00€
  • TAT-AKAP79 (326-336) amide


    The activation of transient receptor potential cation channel subfamily V member 1 (TRPV1) is believed to play a role in hyperalgesia, asthma, and hypertension. TRPV1 is important for neuronal pain detection as well as the detection of heat, capsaicin, protons, and the neurotransmitter anandamide.- The scaffold protein AKAP79 targets kinases to phosphorylate TRPV1, however it has been shown that inflammatory intermediates prostaglandin-E2 or bradykinin can activate these kinases creating a route for inflammation to cause hyperalgesia.This product is composed of the TRPV1 interacting residues of AKAP79 reordered into a scrambled sequence and conjugated to the cell penetrating TAT domain at the N-terminus. This product was shown in vivo to have a potent analgesic affect due to interaction with TRPV1 but not affect the pain threshold. This product is a vital tool for research into suitable TRPV1 antagonists.
    Peso molecolare:2,877.6 g/mol

    Ref: 3D-CRB1001279

    500µg
    206,00€
    1mg
    282,00€
  • Influenza NP (482 - 489)


    Custom research peptide; min purity 95%. For different specs please use the Peptide Quote Tool
    Formula:C44H55N9O15
    Peso molecolare:949.98 g/mol

    Ref: 3D-PP50287

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  • H-DRV^YI^HPFHL-OH


    Peptide H-DRV^YI^HPFHL-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.

    Ref: 3D-PP40937

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  • H-Glu(OtBu)-2-ClTrt-Resin (200-400 mesh) 1% DVB


    H-Glu(OtBu)-2-ClTrt-Resin (200-400 mesh) 1% DVB is a resin that is used in peptide synthesis. It can be used as a building block for the synthesis of peptides and amino acids. H-Glu(OtBu)-2-ClTrt-Resin (200-400 mesh) 1% DVB can also be used to synthesize thiols, alcohols, and amines.
    Purezza:Min. 95%

    Ref: 3D-RHE-1093-PI

    1g
    220,00€
    5g
    733,00€
  • H-QQF^FGLM-NH2


    Peptide H-QQF^FGLM-NH2 is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.

    Ref: 3D-PP41741

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  • [5-FAM]-GLP-1 (7-36)


    The native form of GLP-1 in humans is the GLP-1 (7-36) amide. GLP-1 (7-36) amide is highly unstable (half-life <-2 minutes) due to proteolytic degradation by the serine protease- dipeptidyl peptidase-IV (DPP-IV). DPP-IV cleaves the N-terminal histidine and alanine residues from GLP-1 to generate two equipotent forms: GLP-1 (9-37) and GLP-1 (9-36) amide. This degradation mitigates against the therapeutic use of GLP-1 itself, therefore DPP-IV-resistant peptide analogues have been developed and licensed for clinical useThis peptide contains N-terminal 5-Carboxyfluorescein (5-FAM), a widely used green fluorescent tag

    Peso molecolare:3,653.7 g/mol

    Ref: 3D-CRB1100877

    100µg
    386,00€
    500µg
    470,00€
    1mg
    543,00€
  • H-FAIQDISVEETSAK^-OH


    Peptide H-FAIQDISVEETSAK^-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.

    Ref: 3D-PP43226

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  • nef protein (75-82) [Human immunodeficiency virus 1]


    Nef is an accessory protein highly conserved amongst all primate lentiviruses, it is essential for viral replication in vivo- it is expressed by human immunodeficiency virus (HIV) HIV-1 and HIV-2. Nef acts as a downregulator of class I human leukocyte antigens (HLA) expression in HIV-infected cells to help circumvent the immune response, such as cytotoxic T lymphocytes (CTL) activity. An intact nef gene is critical for high viral loads, linked to development of acquired immunodeficiency syndrome (AIDS). Certain alleles of HLA have been associated with maintaining a seronegative status such as HLA-A*1101. This nef peptide sequence (75-82) was crystallised within the class I B allele HLA B*3501 suggesting an importance of key residues required for HLA interaction resulting in a nonstandard conformational binding.
    Peso molecolare:975.5 g/mol

    Ref: 3D-CRB1001224

    500µg
    206,00€
    1mg
    282,00€
  • Gad1 Blocking Peptide


    A synthetic peptide for use as a blocking control in assays to test for specificity of Gad1 antibody, catalog no. 70R-9261
    Purezza:Min. 95%

    Ref: 3D-33R-9262

    100µg
    265,00€
  • H-GVLLP^QK-OH


    Peptide H-GVLLP^QK-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.

    Ref: 3D-PP43926

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  • H-APLILSR^-OH


    Peptide H-APLILSR^-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.

    Ref: 3D-PP40697

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  • SIVmac239 - 27


    Custom research peptide; min purity 95%. For different specs please use the Peptide Quote Tool
    Peso molecolare:1,699 g/mol

    Ref: 3D-PP50411

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  • [&beta;-Ala]-[Lys(5-TAMRA)]-acid


    [β-Ala]-[Lys(5-TAMRA)]-acid
    Peso molecolare:629.3 g/mol

    Ref: 3D-CRB1101574

    100µg
    206,00€
    500µg
    282,00€
    1mg
    346,00€
    5mg
    633,00€
    10mg
    857,00€
  • H-RIFSTDTGPGGC-Clear-Base Resin


    Peptide H-RIFSTDTGPGGC-Clear-Base Resin is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.

    Ref: 3D-PP46817

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  • Influenza HA (204 - 212)


    Custom research peptide; min purity 95%. For different specs please use the Peptide Quote Tool
    Formula:C49H73N11O15
    Peso molecolare:1,056.19 g/mol

    Ref: 3D-PP50084

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  • CMVpp65 - 55 (QVIGDQYVKVYLESF)


    Custom research peptide; min purity 95%. For different specs please use the Peptide Quote Tool
    Peso molecolare:1,788 g/mol

    Ref: 3D-PP50975

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  • H-GADGVGK^SA-OH


    Peptide H-GADGVGK^SA-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.

    Ref: 3D-PP48947

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  • Ac-TPYWMAPE-NH2


    Peptide Ac-TPYWMAPE-NH2 is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.

    Ref: 3D-PP47416

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  • (D-Pro7)-Angiotensin I/II (1-7)


    The renin angiotensin system (RAS) consists of many angiotensin peptides involved in regulating functions such as blood pressure, cardiovascular function and energy balance. RAS activity is elevated in obesity and RAS is widely studied in relation to lifestyle-related diseases.Angiotensin 1-7 (Ang-(1-7)) is a component of the RAS. Ang-(1-7) is produced by angiotensin-converting enzyme 2 (ACE2), from the angiotensin II (Ang-II) peptide, as well as by prolylendopeptidase (PEP) and neutral endopeptidase (NEP) which produce Ang1 7 directly from angiotensin I (Ang-I).Ang-(1-7) broadly opposes Ang-II actions. Ang-(1-7) has vasodilatory and anti-oxidative effects, and exerts protective actions in hypertension, diabetes, and other cardiovascular disorders, Ang-(1-7) therefore represents a promising therapeutic target for cardiovascular and metabolic diseases. Ang (1-7) exerts its actions via its G-protein-coupled receptor, Mas. This novel arm of the RAS has effects that counterbalance those mediated by the classical ACE/Ang-II pathway.The C-terminal proline fro this peptide is in the D enantiomer.
    Colore e forma:Powder
    Peso molecolare:898.5 g/mol

    Ref: 3D-CRB1000981

    500µg
    206,00€
    1mg
    282,00€
  • [Cys]-Galanin (1-30) Human


    Galanin (1-30) is an endogenous neuropeptide with endocrine, metabolic and behavioural effects. Galanin has a role in intestinal smooth muscle contraction, insulin and somatostatin release, and synaptic neurotransmission.Galanin is widely distributed in the central nervous, peripheral, and endocrine systems. Galanin's overarching function is as an inhibitory, hyper-polarizing neuromodulator for classical neurotransmitters like acetylcholine and serotonin. Galanin interacts with 3 receptor subtypes, GalR1-3 G protein-coupled receptors inserted into the plasma membrane. GalR1 is believed to activate a Gβγ pathway to regulate MAPK activation. GalR2 can also activate the MAPK pathway, but unlike GalR1, there is detectable inositol phosphate production. GalR3 is associated with the G alpha i/o pathway receptor activation leads to a cellular influx of K+. Each receptor has been associated with neurological diseases such as GalR3 and epilepsy.Galanin protects against various physiological insults in vitro, including excitotoxicity and β-amyloid toxicity. Changes in galanin have been widely studied concerning Alzheimer's disease, and galaninergic neurons are spared in late-stage Alzheimer's relative to non-galaninergic neurones.Galanin (1-30) has been used as an agonist for the GalR2 receptor in vitro for calcium mobilisation assays to understand the role Galanin/GalR2 play in multiple sclerosis.An N-terminal cysteine residue has been included on the galanin (1-30) peptide to allow ease of site-specific conjugation to various molecules.
    Peso molecolare:3,258.6 g/mol

    Ref: 3D-CRB1001479

    500µg
    282,00€
    1mg
    386,00€
  • H-ENPVVHFFKNIVTPR-OH


    Peptide H-ENPVVHFFKNIVTPR-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.

    Ref: 3D-PP44292

    1mg
    322,00€
    10mg
    362,00€
    100mg
    657,00€
  • (Tos-YASR)2-[Rh110]


    Optimal peptide substrate for kallikrein-related peptidase 14 (KLK14). In its intact state this peptide is not fluorescent, however when this substrate peptide is cleaved by KLK14, Rhodamine 110 is released and thus fluorescence can then be detected. This peptide therefore allows for the quantification of KLK14 peptidase activity. KLK14 is most abundant in the skin, with lower levels in breast and prostate and may form part of the protease cascade responsible for maintaining the epidermal barrier. Aberrant KLK14 proteolytic activity is linked to several skin pathologies. Overexpression of KLK14 seen in several hormone-dependent cancers, including prostate, colon, ovarian, and breast, correlating with higher risk of disease progression. Therefore KLK14 is a potential point of therapeutic intervention in a variety of pathologies.Contains rhodamine 110 group, a widely used red fluorescent tag. The terminal carboxylic acids in this peptide have been activated by the addition of the p-tosyl moiety, allowing for easy addition of functional groups or further peptide residues.
    Peso molecolare:1,592.6 g/mol

    Ref: 3D-CRB1100444

    100µg
    386,00€
    500µg
    470,00€
    1mg
    651,00€