Endotoxin Inhibitor

CAS: 147396-10-9

Rif. 01-4014453

Informazioni sul prodotto

• Nome: Endotoxin Inhibitor
• Sinonimi: K-T-K-C-K-F-L-K-K-C
• Marchio: Bachem
• Descrizione: The cyclic peptide KTKCKFLKKC has ben shown to form a strong complex with lipid A, the toxic component of the endotoxin lipopolysaccharide (LPS) with Ka = 0.56 · 10⁷ M⁻¹. It detoxifies LPS in vitro and prevents LPS-induced cytokine release and lethality in vivo. Furthermore, it shows neither antibiotic activity nor toxicity and might therefore be useful in the prophylaxis and treatment of LPS-mediated diseases. KTKCKFLKKC bears a structural resemblance to the peptide antibiotic and endotoxin inhibitor polymyxin B. It could be of use as an adjuvant for antibiotic therapy.

Proprietà chimiche

• Peso molecolare: 1224.6
• Formula: C₅₅H₉₇N₁₅O₁₂S₂
• Purezza: 98.8%
• Colore/Forma: White Powder