Informazioni sul prodotto
- 1,5,6,7-Tetrahydro-1,6-dimethylpyrimidino[5,4-e]triazine-5,7-dione
- 1,6-Dimethyl-5,7-dioxo-1,5,6,7-tetrahydropyrimido[5,4-e]-as-triazine
- 84-82-2
- K4394
- NSC 67078
- Pkf 118-310
- Pkf118-310
- Pyrimido[5,4-e]-as-triazine-5,7(1H,6H)-dione, 1,6-dimethyl-
- Sid 4251194
- Toxoflavin
- Vedi altri sinonimi
- Toxoflavine
- Xanthothricin
- Xanthotricin
- pyrimido[5,4-e]-1,2,4-triazine-5,7(1H,6H)-dione, 1,6-dimethyl-
PKF118-310 is a basic protein that has been shown to have significant cytotoxicity against the human cancer cell line K562. PKF118-310 has been shown to induce apoptosis in these cells by binding to cyclin D2, which is a protein involved in the cell cycle. PKF118-310 also inhibits production of prostaglandin E2 and tumor necrosis factor (TNF), which are important mediators of inflammation. PKF118-310 induces phase II detoxification enzymes such as glutathione reductase, cytochrome P450, and esterases through the activation of transcriptional factors such as NF-κB and AP-1. These enzymes are responsible for metabolizing toxic compounds from the body.
Proprietà chimiche
Richiesta tecnica su: 3D-AAA08482 PKF118-310
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