BMS-986143
Rif. 3D-BB179502
| Dimensione non definita | Prezzo su richiesta |
Informazioni sul prodotto
BMS-986143 is a tyrosine kinase inhibitor that has been shown to be effective in the treatment of autoimmune diseases such as rheumatoid arthritis. This drug inhibits the enzyme signal transduction pathway by binding to the ATP site and blocking the phosphorylation of tyrosine residues on the receptor. BMS-986143 is an atropisomeric compound with two enantiomers, which can be separated using chiral chromatography or supercritical fluid chromatography. The most active form of BMS-986143 is S-BMS-986143, which has been shown to have a higher selectivity for inhibiting immune cells (e.g., T cells and macrophages) over normal cells (e.g., neutrophils). The stable form of this drug is S-BMS-986143, which has demonstrated improved potency and stability when compared to R-BMS-986143.
Proprietà chimiche
Richiesta tecnica su: 3D-BB179502 BMS-986143
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