PF 477736
CAS: 952021-60-2
Rif. 3D-CNB02160
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Informazioni sul prodotto
PF 477736 is a chemical inhibitor of the checkpoint kinase 1 (Chk1) that blocks DNA damage-induced cell cycle arrest. It is a potent and selective inhibitor of Chk1 in vitro and in vivo, with IC50 values of 1.6 nM and 0.7 nM, respectively. PF 477736 inhibits hyperproliferative disease progression by blocking the apoptosis pathway at the point where it converges with the cell cycle checkpoint system. This inhibition leads to an accumulation of cells in G2/M phase, which are unable to progress through mitosis because they have not repaired their DNA damage. PF 477736 has been shown to inhibit tumor growth in xenograft models of human bladder cancer, non-small-cell lung cancer, breast cancer, mesothelioma, ovarian cancer, prostate cancer and pancreatic cancer.
