Anti-PERK antibody - serum
Rif. 3D-CRB2005276
| 20µl | 266,00 € | ||
| 100µl | 479,00 € |
Informazioni sul prodotto
Recognizes Integrated stress response (ISR) kinase, PERK, with a strong signal and low background noise.
When there are a large number of misfolded proteins in the cell a homeostatic mechanism called the unfolded protein response (UPR) is activated which involves restricting translation and increasing chaperone capacity. As part of this response, the ER-resident kinase PERK (eukaryotic translation initiation factor 2α kinase, also known as PEK) phosphorylates the translation initiation factor eIF2α resulting in the attenuation of translation.
PERK activation causes loss of cyclin D1 and G1 cell cycle arrest, negatively regulating cell proliferation. PERK-dependent activation of GSK3β during ER stress has been shown to destabilise p53.
Antiserum. Used for western blot (1:1000). Reacts with Drosophila melanogaster.
Image: Western blot analysis of fly heads (three per lane) from indicated genotypes. Blotting for actin provided the loading control. Note the increased level of PERK-WT immunoreactivity in GADD34-rescued flies. This reflects the preservation of PERK expressing retinal tissue.
Proprietà chimiche
Richiesta tecnica su: 3D-CRB2005276 Anti-PERK antibody - serum
Se si desidera richiedere un preventivo o effettuare un ordine, si prega invece di aggiungere i prodotti desiderati al carrello e poi richiedere un preventivo o un ordine dal carrello. È più veloce, più economico, e potrà beneficiare degli sconti disponibili e di altri vantaggi.
