Maritoclax
CAS: 1227962-62-0
Rif. 3D-CZB96262
| 5mg | Prezzo su richiesta | ||
| 10mg | Prezzo su richiesta | ||
| 25mg | Prezzo su richiesta | ||
| 50mg | Prezzo su richiesta | ||
| 100mg | Prezzo su richiesta |
Informazioni sul prodotto
- 1,1'-(4,4',5,5'-Tetrachloro[1,3'-bi-1H-pyrrole]-2,2'-diyl)bis[1-(2-hydroxyphenyl)methanone]
Maritoclax is a low-potency, selective inhibitor of the mcl-1 protein. It has been shown to increase the sensitivity of leukemia cells to chemotherapy by inducing apoptosis in leukemia cells that express wild-type mcl-1 and chemoresistance in those that have mutated the protein. Maritoclax has also been shown to be effective against skin cancer in vivo, where it inhibits proliferation and induces apoptosis. In addition, maritoclax can induce apoptosis in primary cells from human patients with autoimmune diseases such as systemic lupus erythematosus.
Mutations in cyclin D2 may lead to resistance to maritoclax treatment because the drug only works on cells with wild-type cyclin D2 expression. This drug may also be synergistic with other drugs that target cell proliferation, such as gemcitabine or cetuximab.
Proprietà chimiche
Richiesta tecnica su: 3D-CZB96262 Maritoclax
Se si desidera richiedere un preventivo o effettuare un ordine, si prega invece di aggiungere i prodotti desiderati al carrello e poi richiedere un preventivo o un ordine dal carrello. È più veloce, più economico, e potrà beneficiare degli sconti disponibili e di altri vantaggi.
