Desmethylnortriptyline
CAS: 4444-42-2
Rif. 3D-EAA44442
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Informazioni sul prodotto
- 1-Propanamine, 3-(10,11-dihydro-5H-dibenzo(a,d)cyclohepten-5-ylidene)-
- 3-(10,11-Dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-1-propanamine
- 5H-Dibenzo[a,d]cycloheptene-Δ<sup>5,γ</sup>-propylamine, 10,11-dihydro-
- Demethylnortriptyline
- Didesmethylamitriptyline
- Lu 5-079
- N,N-Didemethylamitriptyline
Desmethylnortriptyline is a tricyclic antidepressant drug that has been shown to have anti-inflammatory properties. It inhibits the production of inflammatory cytokines in the intestine, which may be due to its effect on the induction of apoptosis by inhibiting protein synthesis. Desmethylnortriptyline also has a beneficial effect on bowel diseases, such as colitis and ileitis. This drug inhibits the uptake of serotonin in rat brains and can lead to decreased levels of serotonin in the brain and spinal cord, which may be responsible for its clinical response. Desmethylnortriptyline is metabolized by demethylation and deamination. It undergoes oxidative deamination by cytochrome P450 enzymes found in human liver microsomes and isolated heart tissue, generating an inactive product. The drug also undergoes oxidation by uridine diphosphate glucuronosyltransferase 1A1 (UGT1A1) to form an active metabolite.
Proprietà chimiche
Richiesta tecnica su: 3D-EAA44442 Desmethylnortriptyline
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