Bis-(1,3-diethylthiobarbituric acid)trimethine oxonol

CAS: 47623-98-3

Rif. 3D-FB148191

Informazioni sul prodotto

• Nome: Bis-(1,3-diethylthiobarbituric acid)trimethine oxonol
• Sinonimi: 4,6(1H,5H)-Pyrimidinedione, 5-(3-(1,3-diethylhexahydro-4,6-dioxo-2-thioxo-5-pyrimidinyl)-2-propenylidene)-1,3-diethyldihydro-2-thioxo-, 4,6(1H,5H)-Pyrimidinedione, 5-[3-(1,3-diethylhexahydro-4,6-dioxo-2-thioxo-5-pyrimidinyl)-2-propen-1-ylidene]-1,3-diethyldihydro-2-thioxo-, 5,5'-prop-1-en-1-yl-3-ylidenebis(1,3-diethyl-2-thioxodihydropyrimidine-4,6(1H,5H)-dione), 5-[3-(1,3-Diethylhexahydro-4,6-dioxo-2-thioxo-5-pyrimidinyl)-2-propen-1-ylidene]-1,3-diethyldihydro-2-thioxo-4,6(1H,5H)-pyrimidinedione, 5-[3-(1,3-diethyl-6-hydroxy-4-oxo-2-thioxo-1,2,3,4-tetrahydropyrimidin-5-yl)prop-2-en-1-ylidene]-1,3-diethyl-2-thioxodihydropyrimidine-4,6(1H,5H)-dione, Bis(1,3-diethylthiobarbiturate)trimethineoxonol, Bis(1,3-diethylthiobarbituric acid)trimethine oxonol, DiSBAC₂(3)

Descrizione

Bis-(1,3-diethylthiobarbituric acid)trimethine oxonol (BTTMO) is a compound class of drugs that inhibit the ATP-binding cassette transporter and block the transport of cellular metabolites across the mitochondrial membrane. This inhibition leads to a decrease in cellular ATP levels and an increase in cytosolic calcium. BTTMO has shown promising results in animal models for treatment of cervical cancer, which may be due to its ability to stimulate epidermal growth factor receptor signaling. BTTMO also inhibits energy metabolism by inhibiting mitochondrial membrane potential and blocking atp-sensitive potassium channels. It also induces gamma-aminobutyric acid release from neurons, leading to hyperpolarization of the cell membrane.

• Marchio: Biosynth

Proprietà chimiche

• Peso molecolare: 436.55 g/mol
• Formula: C₁₉H₂₄N₄O₄S₂
• Purezza: Min. 95%
• Colore/Forma: Dark Purple Solid
• InChI: InChI=1S/C19H24N4O4S2/c1-5-20-14(24)12(15(25)21(6-2)18(20)28)10-9-11-13-16(26)22(7-3)19(29)23(8-4)17(13)27/h9-12H,5-8H2,1-4H3/b10-9+
• InChI key: InChIKey=VJYNRXFXHKIGLT-MDZDMXLPSA-N
• SMILES: CCN1C(=O)C(=C/C=C/C2C(=O)N(CC)C(=S)N(CC)C2=O)C(=O)N(CC)C1=S