7-Chloro-4-hydroxyquinoline

CAS: 86-99-7

Rif. 3D-FC40597

Informazioni sul prodotto

• Nome: 7-Chloro-4-hydroxyquinoline
• Sinonimi: 4-Hydroxy-7-chloroquinoline, 4-Quinolinol, 7-chloro-, 7-Chloro-4-Quinolinol, 7-chloroquinolin-4(1H)-one, NSC 38928

Descrizione

7-Chloro-4-hydroxyquinoline is a quinoline derivative that has been shown to be an effective anti-tuberculosis agent. It inhibits bacterial growth by binding to DNA and RNA, preventing transcription and replication. The high frequency of human activity has been shown using a patch-clamp technique on human erythrocytes. This active form is metabolized through a number of metabolic transformations, including hydrolysis by esterases or glucuronidases, oxidation by cytochrome P450 enzymes, reduction by glutathione reductase, or conjugation with glucuronic acid. 7-Chloro-4-hydroxyquinoline also specifically binds to markers expressed at high levels in Mycobacterium tuberculosis strains (e.g., ESX-1 secretion system protein) and inhibits cell growth in culture.

• Marchio: Biosynth

Proprietà chimiche

• Peso molecolare: 179.6 g/mol
• Formula: C₉H₆ClNO
• Purezza: (Hplc) Min. 98%
• Colore/Forma: Powder
• InChI: InChI=1S/C9H6ClNO/c10-6-1-2-7-8(5-6)11-4-3-9(7)12/h1-5H,(H,11,12)
• InChI key: InChIKey=XMFXTXKSWIDMER-UHFFFAOYSA-N
• SMILES: O=c1cc[nH]c2cc(Cl)ccc12