(+)-JQ 1

CAS: 1268524-70-4

Rif. 3D-FC43273

Informazioni sul prodotto

• Nome: (+)-JQ 1
• Sinonimi: [(S)-4-(4-Chlorophenyl)-2,3,9-trimethyl-6H-1-thia-5,7,8,9a-tetraaza-cyclopenta[e]azulen-6-yl]-acetic acid tert-butyl ester(S)-(, (+)-Jq1, (S)-(+)-tert-Butyl 2-(4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetate, (S)-Jq1, 1,1-Dimethylethyl (6S)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetate, 6H-Thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetic acid, 4-(4-chlorophenyl)-2,3,9-trimethyl-, 1,1-dimethylethyl ester, (6S)-, BET domain inhibitor JQ1, Bromodomain and extra-terminal domain inhibitor JQ1, JQ1 (BET inhibitor), JQ1 (pharmaceutical), Jq-1, tert-Butyl (S)-2-(4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetate

Descrizione

Potent BET inhibitor with high specificity for acetyl-lysine recognition motifs found in the BET family (Brd2, Brd3, Brd4, Brdt). Engages with bromodomain pocket and competes with acetylated peptide binding, causing displacement of BET proteins from chromatin and disrupting transcription. Has been used in clinical trials as chemotherapy and male contraceptive.

• Marchio: Biosynth

Proprietà chimiche

• Peso molecolare: 456.99 g/mol
• Formula: C₂₃H₂₅ClN₄O₂S
• Purezza: Min. 95%
• Colore/Forma: White Powder
• InChI: InChI=1S/C23H25ClN4O2S/c1-12-13(2)31-22-19(12)20(15-7-9-16(24)10-8-15)25-17(11-18(29)30-23(4,5)6)21-27-26-14(3)28(21)22/h7-10,17H,11H2,1-6H3/t17-/m0/s1
• InChI key: InChIKey=DNVXATUJJDPFDM-KRWDZBQOSA-N
• SMILES: Cc1sc2c(c1C)C(c1ccc(Cl)cc1)=N[C@@H](CC(=O)OC(C)(C)C)c1nnc(C)n1-2