Mertansine

CAS: 139504-50-0

Rif. 3D-FD33453

Informazioni sul prodotto

• Nome: Mertansine
• Sinonimi: N2'-Deacetyl-N2'-(3-mercapto-1-oxopropyl)maytansine DM 1Maytansinoid DM 1, DM 1, N2′-Deacetyl-N2′-(3-mercapto-1-oxopropyl)maytansine, Maytansine, N2′-deacetyl-N2′-(3-mercapto-1-oxopropyl)-, Maytansinoid DM 1

Descrizione

N2'-Deacetyl-N2'-(3-mercapto-1-oxopropyl)-maytansine is a thiol-containing derivative of maytansine. Maytansine and its derivatives kill cells by interfering with the formation of microtubules, and causing the depolymerisation of already formed microtubules. Antibody conjugates of N2'-Deacetyl-N2'-(3-mercapto-1-oxopropyl)-maytansine and the murine monoclonal antibody TA. 1, using linkers containing either a disulfide bond or a thioether bond, have been synthesised. These antibody conjugates bind to the HER-2/new oncogene protein that is expressed on human breast tumor cells.

• Marchio: Biosynth

Proprietà chimiche

• Peso molecolare: 738.29 g/mol
• Formula: C₃₅H₄₈ClN₃O₁₀S
• Purezza: Min. 95%
• Colore/Forma: White Off-White Yellow Powder