2,3-Diamino-5-bromopyridine
CAS: 38875-53-5
Rif. 3D-FD57703
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Informazioni sul prodotto
- 2,3-Diamino-5-Bromopyridinium
- 2,3-Pyridinediamine, 5-bromo-
- 5-Bromo-2,3-pyridinediamine
- 5-Bromopyridine-2,3-diamine
- Pyridine, 2,3-diamino-5-bromo-
2,3-Diamino-5-bromopyridine (2,3-DBP) is a unsymmetrical diamine that can be used as a cancer therapeutic. 2,3-DBP inhibits the activity of multidrug efflux pumps in cancer cells by binding to the transporter protein and inhibiting its function. This drug also inhibits glycogen synthase kinase-3 (GSK-3), which is an enzyme with tumor suppressor properties. In addition, 2,3-DBP is cytotoxic to cancer cells in vitro and has been shown to inhibit tumor growth in vivo. 2,3-DBP was shown to have an IC50 of ~8 μM for the efflux pump MDR1 and ~4 μM for Pgp. It also showed cytotoxicity against a panel of human cancer cell lines at concentrations ranging from 10 nM to 1 μM.
Proprietà chimiche
Richiesta tecnica su: 3D-FD57703 2,3-Diamino-5-bromopyridine
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