R-(+)-Etomoxir

CAS: 124083-20-1

Rif. 3D-FE23200

Informazioni sul prodotto

• Nome: R-(+)-Etomoxir
• Sinonimi: (R)-2-[6-(4-Chlorophenoxy)hexyl]oxiranecarboxylic acid, ethyl ester, (R)-(+)-Etomoxir, (R)-Ethyl 2-(6-(4-chlorophenoxy)hexyl)oxirane-2-carboxylate, 2-Oxiranecarboxylic acid, 2-[6-(4-chlorophenoxy)hexyl]-, ethyl ester, (2R)-, Ethyl (+)-(R)-2-(6-(p-chlorophenoxy)hexyl)glycidate, Etomoxir [INN], Oxiranecarboxylic acid, 2-[6-(4-chlorophenoxy)hexyl]-, ethyl ester, (2R)-, Oxiranecarboxylic acid, 2-[6-(4-chlorophenoxy)hexyl]-, ethyl ester, (R)-, Unii-Msb3Dd2Xp6, ethyl (2R)-2-[6-(4-chlorophenoxy)hexyl]oxirane-2-carboxylate, ethyl (2S)-2-[6-(4-chlorophenoxy)hexyl]oxirane-2-carboxylate

Descrizione

Etomoxir is a potent inhibitor of the mitochondrial enzyme, fatty acid: 2-enoyl-CoA reductase. This enzyme catalyzes the conversion of long-chain acyl-CoA to acetyl-CoA, which is required for the synthesis of mitochondrial membrane phospholipids and cardiolipin. Etomoxir inhibits this activity and consequently prevents the production of ATP. It also inhibits oxidative phosphorylation in isolated mitochondria and reduces locomotor activity in rats. Etomoxir has been shown to have inhibitory properties on human malignant brain cells as well as breast cancer cells (MDA-MB-231).

• Marchio: Biosynth

Proprietà chimiche

• Peso molecolare: 326.81 g/mol
• Formula: C₁₇H₂₃ClO₄
• Purezza: Min. 95%
• InChI: InChI=1S/C17H23ClO4/c1-2-20-16(19)17(13-22-17)11-5-3-4-6-12-21-15-9-7-14(18)8-10-15/h7-10H,2-6,11-13H2,1H3/t17-/m1/s1
• InChI key: InChIKey=DZLOHEOHWICNIL-QGZVFWFLSA-N
• SMILES: CCOC(=O)[C@@]1(CCCCCCOc2ccc(Cl)cc2)CO1