4-Hydroxy-17b-estradiol
CAS: 5976-61-4
Rif. 3D-FH24183
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| 500µg | Prezzo su richiesta |
Informazioni sul prodotto
- (17b)-Estra-1,3,5(10)-triene-3,4,17-triol4-Hydroxyestradiol
4-Hydroxy-17β-estradiol (4-OHE2) is a reactive metabolite of 17β-estradiol that binds to DNA and has been shown to have carcinogenic potential. The catechol-o-methyltransferase enzyme catalyzes the conversion of 4-OHE2 to 4-hydroxycatechol, which can then be further methylated by estrogen sulfotransferase or sulfatase to estrone and estrone sulfate. It has been shown that 4-OHE2 may be a potential biomarker for breast cancer. Experimental studies have shown that 4-OHE2 may act as an antioxidant in cancer tissues, but its activity has not been demonstrated in normal tissues. In order to demonstrate the ability of 4-OHE2 as an antioxidant, its activity was tested in vitro using human breast cancer cells (MDA MB 231). Results showed that 4-OHE2 decreased oxidative stress levels in these cells,
Proprietà chimiche
Richiesta tecnica su: 3D-FH24183 4-Hydroxy-17b-estradiol
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