RG3039
CAS: 1005504-62-0
Rif. 3D-FQB50462
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Informazioni sul prodotto
RG3039 is a novel small molecule that has been shown to have anti-leukemic activity in vitro and in vivo. RG3039 binds to the splicing machinery of the RNA spliceosome, which is essential for regulating gene expression. It also inhibits the phosphorylation of eukaryotic translation initiation factor 2α (eIF2α) and reduces global protein synthesis. This drug also has an effect on primary cells from patients with AML or MDS and inhibits leukemia cell proliferation. The effective dose for RG3039 was found to be around 10 μM for human cells, but this may vary depending on the cell type. The safety profile of RG3039 appears to be favorable in preclinical studies, with no signs of toxicity observed up to a dose of 50 μM.
RG3039 is a novel small molecule that has been shown to have anti-leukemic activity in vitro and in vivo. RG3039 binds to the splicing machinery of
Proprietà chimiche
Richiesta tecnica su: 3D-FQB50462 RG3039
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