Informazioni sul prodotto
TGR 1202 is a monoclonal antibody that modulates the immune system. It has been shown to inhibit the activation of PI3K-δ, which plays a role in T-cell lymphomas and hematologic response. TGR 1202 also has minimal toxicity, with no adverse effects seen at doses up to 1.5 mg/kg in vivo. TGR 1202 binds to receptors on lymphocytes, leading to cell apoptosis and inhibition of proliferation. The drug is active against monoclonal antibody-resistant leukemic mice and has synergistic effects when used with other drugs like ibrutinib or lenalidomide. Pharmacokinetic properties have been studied in mice, dogs, and monkeys.
TGR 1202 shows good pharmacokinetics in vivo, with a half-life of about 10 hours in mice, dogs, and monkeys.
Proprietà chimiche
Richiesta tecnica su: 3D-FT171036 TGR 1202
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