Informazioni sul prodotto
Tacrolimus is a macrolide antibiotic that binds to the calcineurin receptor and inhibits the production of cytokines. It is used to treat certain types of autoimmunity and hyperproliferation in patients with cancer, organ transplant recipients, and those who have undergone radiation therapy. The drug is available in two forms: tacrolimus (the natural form) and desmethyl tacrolimus (a metabolite). Desmethyl tacrolimus is produced by microbial transformation, which converts the natural form into a more water-soluble derivative. This conversion can be prevented by adding additives such as proton pump inhibitors or pde5 inhibitors. Symptoms of tacrolimus include hyperglycemia, hyperlipidemia, gastrointestinal disturbances, headache, fever, skin rash, diarrhea, and anemia. Tacrolimus has been shown to inhibit the activity of fk506-binding proteins in vitro and in vivo through competitive inhibition.
Proprietà chimiche
Richiesta tecnica su: 3D-ID158723 Desmethyl tacrolimus
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