LY2955303
CAS: 1433497-19-8
Rif. 3D-IHC49719
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Informazioni sul prodotto
LY2955303 is a synthetic retinoid that has been shown to be effective in the treatment of pancreatic cancer. LY2955303 acts by binding to all-trans retinoic acid receptors, which are expressed on the surface of cancer cells. This drug binds to the receptor and inhibits proliferation and induces apoptosis in pancreatic cancer cells. LY2955303 also inhibits esophageal adenocarcinoma cell proliferation, as well as inducing apoptosis via the same mechanism. The crystal structure of LY2955303 bound to an all-trans retinoic acid receptor has been determined using X-ray crystallography. The structure reveals that this drug interacts with a hydrophobic pocket on the surface of the receptor, preventing it from activating transcription factors inside the cell nucleus. LY2955303 also has pharmacokinetic properties similar to those of other retinoids, with a rapid absorption rate that is followed by a slow elimination phase.
Proprietà chimiche
Richiesta tecnica su: 3D-IHC49719 LY2955303
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