CXD101
CAS: 934828-12-3
Rif. 3D-JMB82812
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Informazioni sul prodotto
CXD101 is a small molecule inhibitor of histone deacetylase (HDAC) enzymes. It is a potent, selective, and reversible inhibitor of HDACs 1, 2, and 3. CXD101 has been shown to induce cell death in solid tumours through the inhibition of HDACs. In vitro studies have shown that it inhibits the growth of cancer cells by inducing apoptosis and inhibiting the transcriptional activity of Hdac enzymes on histones. These findings indicate that CXD101 may be useful for the treatment of cancers. CXD101 has been well tolerated in clinical trials with no significant adverse effects reported.
CXD101 is an amide-linked prodrug which undergoes rapid acetylation by esterases in vivo to form its active metabolite, cixutumumab (CX1001). Acetylation occurs mainly in the liver, followed by rapid elimination from plasma with a half-life of
Proprietà chimiche
Richiesta tecnica su: 3D-JMB82812 CXD101
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