8-(2-Aminoethyl)aminoadenosine 3',5'-cyclic monophosphate
CAS: 61363-29-9
Rif. 3D-NA09017
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Informazioni sul prodotto
- 8-AEA-cAMP8-(2-Aminoethyl)amino-D-adenosine-3',5'-cyclic monophosphate
- 4H-Furo[3,2-d]-1,3,2-dioxaphosphorin,adenosine deriv.
- 8-(b-Aminoethylamino)adenosine 3',5'-cyclic phosphate
8-(2-Aminoethyl)aminoadenosine 3',5'-cyclic monophosphate (8-AEACMP) is a structural analog of the purine nucleotide adenosine. It has been shown to be an effective inhibitor of HIV replication in vitro and in vivo. 8-AEACMP blocks HIV transcription by binding to the cellular target, the enzyme ribonucleotide reductase. This binding prevents the formation of an enzyme-substrate complex that is required for DNA synthesis. 8-AEACMP binds to two sites on this enzyme: one site is at a catalytic site that is not involved in substrate binding, and the other site is at a regulatory site. The inhibitory effect of 8-AEACMP on HIV transcription results from its ability to bind at both sites simultaneously.
Proprietà chimiche
Richiesta tecnica su: 3D-NA09017 8-(2-Aminoethyl)aminoadenosine 3',5'-cyclic monophosphate
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