Ganglioside GM1

CAS: 37758-47-7

Rif. 3D-OG03918

Informazioni sul prodotto

• Nome: Ganglioside GM1
• Sinonimi: Gal(b1-3)GalNAc(b1-4)[Neu5Ac(a2-3)]Gal(b1-4)Glc(b1-1)CersMonosialogangl ioside GM1prototype gangliosidemonosialotetrahexosylganglioside Ganglioside Monosialotetrahexosylganglioside
• Marchio: Biosynth
• Descrizione: Ganglioside GM1 has a core tetrasaccharide structure (Galβ1,3GalNAcβ1,4Galβ1,4Glc) with sialic acid linked α2,3 to the inner galactose residue, ceramide linked β to position 1 on the reducing terminal glucose residue (Ledeen, 2009), and is abundant in all mammalian brains, where it covers 10%-20% of the total ganglioside mixture. Ganglioside GM1 is found in epithelial membranes and is a key element for the detection of bacterial toxicity and viral infection. It is the intestinal receptor for cholera toxin, the B-subunits of heat-labile toxin (LTB) from E.coli, for rotavirus, and simian virus 40. GM1 functions as a neurotrophic and neuroprotective compound and has been used therapeutically for diabetic and peripheral neuropathies. It also has the ability to bind amyloid-β proteins and is involved in Alzheimer’s pathogenesis (Chiricozzi, 2020).

Proprietà chimiche

• Peso molecolare: 1,546.82 g/mol
• Formula: C₇₃H₁₃₁N₃O₃₁·xNa
• Purezza: Min. 95 Area-%
• Colore/Forma: White Powder