Informazioni sul prodotto
- GlobosidesGal (b1-4) GlcNAc (b1-3) Gal (b1-4) Glc b1-1' CeramideLacto-N-neotetraosyl ceramide
Neolactotetraosylceramide (NT4) is a glycoconjugate that is found in human serum. It has been shown to bind to the receptor site of monoclonal antibodies and inhibit the binding of tumor necrosis factor-α (TNF-α), which is involved in immune system regulation. NT4 has also been shown to block the activity of receptors on human neutrophils, which may be due to its structural similarity to lactotetraosylceramide. NT4 has been implicated as a potential cause for autoimmune diseases and cancer tissues, due to its structural similarity with glycoproteins that are found on cell surfaces. The optimum pH for NT4 is 7.5 and its glycan structure consists of two mannose residues linked by an alpha-1,6 linkage. This glycoconjugate binds well with blood group A and B antigens, but not with blood group O antigen. NT4 elicits antibody response
Proprietà chimiche
Richiesta tecnica su: 3D-ON29191 Neolactotetraosylceramide
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