AC480 (BMS-599626)
CAS: 714971-09-2
Rif. 3D-PDB97109
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Informazioni sul prodotto
- (3S)-3-Morpholinylmethyl (4-{[1-(3-fluorobenzyl)-1H-indazol-5-yl]amino}-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yl)carbamate
- Carbamic acid, N-[4-[[1-[(3-fluorophenyl)methyl]-1H-indazol-5-yl]amino]-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yl]-, (3S)-3-morpholinylmethyl ester
- Ac480
- (3S)-morpholin-3-ylmethyl N-[4-({1-[(3-fluorophenyl)methyl]-1H-indazol-5-yl}amino)-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yl]carbamate
AC480 is a small molecule inhibitor of the epidermal growth factor receptor (EGFR) that has been shown to produce light emission in a variety of cell lines. When AC480 binds to EGFR, it inhibits its kinase activity, which prevents the receptor from transmitting signals that stimulate cell growth. AC480 has a high degree of selectivity for EGFR over other kinases and has been shown to inhibit tumor growth in animal models. In addition, AC480 enhances radiation-induced cell death in prostate cancer cells. This drug also inhibits the production of antibodies associated with autoimmune diseases and may be used to treat these conditions.
Proprietà chimiche
Richiesta tecnica su: 3D-PDB97109 AC480 (BMS-599626)
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