TBK1/IKKµ-IN-2
CAS: 1292310-49-6
Rif. 3D-SBC31049
5mg | Fuori produzione | ||
10mg | Fuori produzione | ||
25mg | Fuori produzione | ||
50mg | Fuori produzione | ||
100mg | Fuori produzione |
Informazioni sul prodotto
BMS-345541 is a selective inhibitor of TBK1/IKKµ-IN-2, a protein complex that plays an important role in the inflammatory response. It inhibits the phosphorylation of IκBα and IKKβ (inhibitors of NF-κB), thereby suppressing the activation of NF-κB and its downstream inflammatory cytokines. BMS-345541 has been shown to inhibit proinflammatory cytokine production in vitro and in vivo in animals. The drug interacts with both catalytic subunits of TBK1/IKKµ-IN-2, suggesting that it may be used as a potential therapeutic agent for inflammatory conditions such as rheumatoid arthritis or Crohn's disease.