GSK J5
CAS: 1394854-51-3
Rif. 3D-UFC85451
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Informazioni sul prodotto
GSK J5 is a lysine-specific histone methyltransferase inhibitor that is used to treat cancer and autoimmune diseases. GSK J5 inhibits the activity of histone methyltransferases, which are enzymes that transfer methyl groups to specific lysine residues in the chromatin. This results in transcriptional repression, which can be reversed by removing the drug. GSK J5 has been shown to cause cell cycle arrest and apoptosis in primary cells and inhibit endothelial cell proliferation in vitro. In vivo treatment with GSK J5 has been shown to reduce insulin resistance, thereby improving insulin sensitivity and decreasing tumour size in animal models of diabetes.
GSK J5 is a potent inhibitor of HDACs (histone deacetylase) which are enzymes that remove acetyl groups from histones, leading to transcriptional activation. GSK J5 also downregulates the expression of growth factors such as VEGF (vascular endothelial growth factor) and PD
Proprietà chimiche
Richiesta tecnica su: 3D-UFC85451 GSK J5
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