Informazioni sul prodotto
- Cdd-0102
CDD0102 is a potent, selective inhibitor of the voltage-gated sodium channel (VGSC) with IC50 values of 2.4 nM for Nav1.8 and 3.2 nM for Nav1.7. CDD0102 is also a highly potent inhibitor of Nav1.5 with an IC50 value of 0.5 nM, which is more than 100-fold better than that of other sodium channel blockers such as tetrodotoxin, saxitoxin, and batrachotoxinin A.
CDD0102 exhibits high affinity binding to the extracellular domain of the VGSCs and has been shown to inhibit both Nav1.8 and Nav1.7 in whole cells with similar potency, while having no effect on other ion channels tested including those belonging to the voltage-gated potassium channel family or the calcium channel family.END>
Proprietà chimiche
Richiesta tecnica su: 3D-WFA42258 CDD0102
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