48-56-1218 - ganglioside-gm2-n-oktadecyl

The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Human GM2A. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Human GM2A. Next, Avidin conjugated to Horseradish Peroxidase (HRP) is added to each microplate well and incubated. After TMB substrate solution is added, only those wells that contain Human GM2A, biotin-conjugated antibody and enzyme-conjugated Avidin will exhibit a change in color. The enzyme-substrate reaction is terminated by the addition of sulphuric acid solution and the color change is measured spectrophotometrically at a wavelength of 450nm ± 10nm. The concentration of Human GM2A in the samples is then determined by comparing the OD of the samples to the standard curve.

The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Human GM2A. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Human GM2A. Next, Avidin conjugated to Horseradish Peroxidase (HRP) is added to each microplate well and incubated. After TMB substrate solution is added, only those wells that contain Human GM2A, biotin-conjugated antibody and enzyme-conjugated Avidin will exhibit a change in color. The enzyme-substrate reaction is terminated by the addition of sulphuric acid solution and the color change is measured spectrophotometrically at a wavelength of 450nm ± 10nm. The concentration of Human GM2A in the samples is then determined by comparing the OD of the samples to the standard curve.

Ganglioside GM1

ganglioside gM3 (phyto-type)

GD3 Ganglioside sodium is a crucial ganglioside in human melanoma and functions as an inducer of mitochondrial permeability. It targets mitochondria directly in a manner controlled by bcl-2. Following the aggregation of death-inducing receptors, ceramide accumulates rapidly, synthesizes GD3 ganglioside, and triggers apoptosis.

Ganglioside GD3, precursor to complex gangliosides, induces apoptosis and alters mitochondrial potential; affects cell growth, invasion, and neurogenesis.

Ganglioside GQ1b, a tetrasialoganglioside, prompts cell differentiation and phosphorylation in neurons and skin cells.

Ganglioside GD1a, a glycosphingolipid in various organs, boosts tumor growth and vascular proliferation, and serves as a TLR2 coreceptor.

GM3 ganglioside inhibits tumor growth, angiogenesis, and HUVEC migration by disrupting cell signaling and insulin receptors.

GM2 is a glycosphingolipid in cell membranes, high in Sandhoff, Tay-Sachs, Niemann-Pick A, C1, C2, and some lysosomal storage diseases.

GD1b: acidic glycosphingolipid with two sialic acids linked to galactose, in plasma membranes, modulates cell signaling, increasing brain levels with age.

GT1b, a trisialoganglioside, binds neurotoxins and MCPyV VP1, inhibits IL-6, IL-10, IgG, IgM, IgA, and has C18:1/C20:1 sphingoid backbones.

GM1 asialo, a cleaved GM1 ganglioside, boosts host defense against P. aeruginosa and RSV, affecting NK and T cells and IFN-γ levels.

GM1, a monosialylated ganglioside, is common in cells, aids growth receptors, calcium influx, and neuronal outgrowth, and interacts with toxins.

Asialo-GM2: a glycosphingolipid lacking sialic acid, accumulates in Tay-Sachs/Sandhoff diseases, binds bacteria.

Ganglioside GD3 disodium salt is a melanoma-associated antigen often targeted in immune therapy for melanomas.