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Potassium hydrogen phthalate is a corrosion inhibitor and a co-catalyst for the production of polyvinyl chloride. It has been shown to exhibit toxic effects on the central nervous system, liver, and kidneys in animal studies. Potassium hydrogen phthalate is also used as a corrosion inhibitor in wastewater treatment plants. The toxicity of potassium hydrogen phthalate may be due to its ability to inhibit ryanodine receptor, an intracellular calcium release channel that regulates cellular functions such as muscle contraction, enzyme activities, and cell cycle progression. Potassium hydrogen phthalate can also be used to produce polyvinyl chloride. It has been shown to have toxic effects on insects as well as thermodynamic data related to water vapor. Potassium hydrogen phthalate is an analytical reagent that can be used for picolinic acid determination.