:internalReference - hydroxycarbamide | 127-07-1

Hydroxycarbamide

HYDROXYCARBAMIDE CRS

<p>Hydroxyurea is used as an inhibitor of DNA synthesis and an anti-cancer drug. It is used as a precursor to prepare 1-hydroxy-5,6-dimethyl-1H-pyrimidine-2,4-dione via reaction with 2-methyl-3-oxo-butyric acid ethyl ester. It is used in the treatment of melanoma, resistant chronic myelocytic leukemia </p>

Hydroxyurea (Hydroxycarbamide), an antineoplastic agent, inhibits DNA synthesis through the inhibition of ribonucleoside diphosphate reductase.

<p>Stability Hygroscopic<br>Applications An anti-neoplastic - inhibits ribonucleoside reductase and DNA replication. A potential therapy for sickle cell anemia which involves the nitrosylation of sickle cell hemoglobin. Horseradish peroxidase catalyzes nitric oxide formation from hydroxyurea in the presence of hydrogen peroxide.<br>References Ratcliffe, W., et al.: Lancet, 339, 164 (1992), Roodman, G., et al.: Cancer, 80, 1557 (1997), Horwitz, M., et al.: J. Clin. Endocrinol. Metab., 2003, 88, 1603 (2003),<br></p>

<p>Hydroxyurea is a prodrug that is activated by the enzyme Jak2, which is found in the mitochondria of cells. Hydroxyurea is used to treat various types of cancer and other diseases, such as sickle cell anemia. It has been shown to be effective in inhibiting the growth of squamous cell carcinomas and myeloid leukemia cells. Hydroxyurea has also been shown to have synergistic effects when combined with other pharmacological agents, such as hydroxycarbamide and cytosine arabinoside. Hydroxyurea inhibits the production of energy in the form of ATP, which leads to death by apoptosis or necrosis. This drug also has inhibitory properties against bacterial infections, especially those caused by Mycobacterium tuberculosis and Mycobacterium avium complex.</p>

Non-aromatic organic derivatives of hydrazine or of hydroxylamine for use as drugs

Hydroxyurea

Hydroxyurea

<p>1-Hydroxyurea</p>