AC-10628 - 4-biphenylcarboxylic-acid-98 | 92-92-2

4-(4-Ethylphenyl)Benzoic Acid

4'-Ethylbiphenyl-4-carboxylic acid is a natural compound that has been shown to be an antioxidant and a potent inhibitor of neprilysin, an enzyme that degrades the peptides angiotensin I and II. This compound binds to the mineralocorticoid receptor (MR) and inhibits MR activation by blocking its interaction with specific ligands such as aldosterone, cortisol, and corticosterone. MR is a transcription factor which regulates the expression of genes involved in metabolism, cell growth, inflammatory response, and blood pressure regulation. There are many different mechanisms through which 4'-ethylbiphenyl-4-carboxylic acid blocks MR activation including inhibiting protein synthesis and preventing receptor dimerization.