AC-46513 - scutellarin | 27740-01-8

Scutellarin analytical standard provided with w/w absolute assay, to be used for quantitative titration.

Scutellarin

Scutellarin has many pharmacological effects, such as antioxidant, antitumor, antiviral, neuroprotection and antiinflammatory activities. It down-regulates the STAT3/Girdin/Akt signaling in HCC cells, and inhibits RANKL-mediated MAPK and NF-κB signaling pathway in osteoclasts.

<p>Scutellarin from Scutellaria inhibits RANKL in osteoclasts and STAT3/Girdin/Akt in HCC cells.</p>

Natural glycoside

<p>Applications Scutellarin is an active flavonoid component from the medical plant Erigeron breviscapus (Vant) Hand-Mazz. Scutellarin is used as a micrpcirculation promoter for the treatment of cardio-cerebrovascular diseases. Studies suggest that Scutellarin has anti-cancer properties and has been shown to enhance apoptosis of tumor cells.<br>References Gao, C. et al.: Drug Metab. Dispos., 39, 2034 (2011); Chan, J.Y. et al.: Anticancer Res., 29, 3043 (2009); Wang, C.-Z. et al.: Phytomedicine, 17, 63 (2010);<br></p>

<p>Scutellarin is a bioactive flavonoid compound, which is derived primarily from the plant Scutellaria baicalensis and other species within the Scutellaria genus. As a naturally occurring phytochemical, Scutellarin exerts its effects through multiple biological pathways, including antioxidant, anti-inflammatory, and anti-apoptotic activities.</p>

(2S,3S,4S,5R,6S)-6-((5,6-Dihydroxy-2-(4-Hydroxyphenyl)-4-Oxo-4H-Chromen-7-Yl)Oxy)-3,4,5-Trihydroxytetrahydro-2H-Pyran-2-Carboxylic Acid