PLB (phospho Ser16/T17) rabbit pAb
Rif. EK-ES6622
| 50µl | 188,00 € | ||
| 100µl | 316,00 € |
Informazioni sul prodotto
- PLN; PLB; Cardiac phospholamban; PLB
The protein encoded by this gene is found as a pentamer and is a major substrate for the cAMP-dependent protein kinase in cardiac muscle. The encoded protein is an inhibitor of cardiac muscle sarcoplasmic reticulum Ca(2+)-ATPase in the unphosphorylated state, but inhibition is relieved upon phosphorylation of the protein. The subsequent activation of the Ca(2+) pump leads to enhanced muscle relaxation rates, thereby contributing to the inotropic response elicited in heart by beta-agonists. The encoded protein is a key regulator of cardiac diastolic function. Mutations in this gene are a cause of inherited human dilated cardiomyopathy with refractory congestive heart failure, and also familial hypertrophic cardiomyopathy. [provided by RefSeq, Apr 2016],
Proprietà chimiche
Richiesta tecnica su: EK-ES6622 PLB (phospho Ser16/T17) rabbit pAb
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